iTox – integrative toxicology
In iTox we aim to integrate data and knowledge from different fields of toxicology to investigate molecular toxicological events and their relation to adverse outcomes on the organism scale. The integration of own data with knowledge and data from databases and other sources is key in our research that aims at understanding general and specific toxicological processes relevant for human and environmental health.
In different projects we work on the investigation, modelling and visualisation of toxicogenomic effects in zebrafish embryos and study time and concentration dependencies as well as mixture and recovery effects (see also: https://webapp.ufz.de/itox/tfpbrowser/).
Furthermore, we collect, investigate and apply mode of action knowledge and effect data of chemicals for environmental mixture risk assessment and develop tools for data management and data integration.
Tools and Software
a R Shiny tool for exploration and visualization of time and concentration dependent toxicogenomic data obtained with the zebrafish embryo model
INTOB-ZFE
Integrated software and database for effect observations on organism scale
Group members
If you are interested in joining the group please contact Wibke Busch
Dr. Wibke Busch
Working Group Leader
Phone: +49 341 235 1581
E-Mail
Paul Michaelis
Bioinformatican
Phone: +49 341 235 4751
E-Mail
Anton Schnurpel
Student assistant
E-Mail
Publications
Index:
You could use our publication index for further requests.
2023 (3)
- Beckers, L.-M., Altenburger, R., Brack, W., Escher, B.I., Hackermüller, J., Hassold, E., Illing, G., Krauss, M., Krüger, J., Michaelis, P., Schüttler, A., Stevens, S., Busch, W. (2023):
A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment
Environ. Int. 179 , art. 108155
full text (doi) - Schmeisser, S., Miccoli, A., von Bergen, M., Berggren, E., Braeuning, A., Busch, W., Desaintes, C., Gourmelon, A., Grafström, R., Harrill, J., Hartung, T., Herzler, M., Kass, G.E.N., Kleinstreuer, N., Leist, M., Luijten, M., Marx-Stoelting, P., Poetz, O., van Ravenzwaay, B., Roggeband, R., Rogiers, V., Roth, A., Sanders, P., Thomas, R.S., Vinggaard, A.M., Vinken, M., van de Water, B., Luch, A., Tralau, T. (2023):
New approach methodologies in human regulatory toxicology – Not if, but how and when!
Environ. Int. 178 , art. 108082
full text (doi) - Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
Chem.-Biol. Interact. 382 , art. 110565
full text (doi)
2022 (5)
- Finckh, S., Beckers, L.-M., Busch, W., Carmona, E., Dulio, V., Kramer, L., Krauss, M., Posthuma, L., Schulze, T., Slootweg, J., von der Ohe, P.C., Brack, W. (2022):
A risk based assessment approach for chemical mixtures from wastewater treatment plant effluents
Environ. Int. 164 , art. 107234
full text (doi) - Finckh, S., Beckers, L.-M., Busch, W., Carmona, E., Dulio, V., Kramer, L., Krauss, M., Posthuma, L., Schulze, T., Slootweg, J., von der Ohe, P.C., Brack, W. (2022):
Concentrations of 366 emerging chemicals in 56 European wastewater treatment plant effluents by LC-HRMS target screening
PANGAEA 10.1594/PANGAEA.940755 - Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35
full text (doi) - Schor, J., Scheibe, P., Bernt, M., Busch, W., Lai, C., Hackermüller, J. (2022):
AI for predicting chemical-effect associations at the chemical universe level — deepFPlearn
Brief. Bioinform. 23 (5), bbac257
full text (doi) - Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
Toxicol. Lett. 368 (Suppl.), S252 - S252
full text (doi)
2021 (2)
- Schüttler, A., Jakobs, G., Fix, J.M., Krauss, M., Krüger, J., Leuthold, D., Altenburger, R., Busch, W. (2021):
Transcriptome-wide prediction and measurement of combined effects induced by chemical mixture exposure in zebrafish embryos
Environ. Health Perspect. 129 (4), art. 047006
full text (doi) - Weitere, M., Altenburger, R., Anlanger, C., Baborowski, M., Bärlund, I., Beckers, L.-M., Borchardt, D., Brack, W., Brase, L., Busch, W., Chatzinotas, A., Deutschmann, B., Eligehausen, J., Frank, K., Graeber, D., Griebler, C., Hagemann, J., Herzsprung, P., Hollert, H., Inostroza, P.A., Jäger, C.G., Kallies, R., Kamjunke, N., Karrasch, B., Kaschuba, S., Kaus, A., Klauer, B., Knöller, K., Koschorreck, M., Krauss, M., Kunz, J.V., Kurz, M.J., Liess, M., Mages, M., Müller, C., Muschket, M., Musolff, A., Norf, H., Pöhlein, F., Reiber, L., Risse-Buhl, U., Schramm, K.-W., Schmitt-Jansen, M., Schmitz, M., Strachauer, U., von Tümpling, W., Weber, N., Wild, R., Wolf, C., Brauns, M. (2021):
Disentangling multiple chemical and non-chemical stressors in a lotic ecosystem using a longitudinal approach
Sci. Total Environ. 769 , art. 144324
full text (doi)
2020 (4)
- Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388
full text (doi) - Jakobs, G., Krüger, J., Schüttler, A., Altenburger, R., Busch, W. (2020):
Mixture toxicity analysis in zebrafish embryo a time and concentration resolved study on mixture effect predictivity
Environ. Sci. Eur. 32 , art. 143
full text (doi) - Krämer, S., Busch, W., Schüttler, A. (2020):
A self-organizing map of the fathead minnow liver transcriptome to identify consistent toxicogenomic patterns across chemical fingerprints
Environ. Toxicol. Chem. 39 (3), 526 - 537
full text (doi) - Shatilina, Z., Drozdova, P., Bedulina, D., Rivarola-Duarte, L., Schreiber, S., Otto, C., Jühling, F., Aulhorn, S., Busch, W., Lubyaga, Y., Kondrateva, E., Pobezhimova, T., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Pörtner, H.-O., Stadler, P.F., Luckenbach, T., Timofeyev, M. (2020):
Transcriptome-level effects of the model organic pollutant phenanthrene and its solvent acetone in three amphipod species
Comp. Biochem. Physiol. D-Genomics Proteomics 33 , art. 100630
full text (doi)
2019 (6)
- Altenburger, R., Brack, W., Burgess, R.M., Busch, W., Escher, B.I., Focks, A., Hewitt, L.M., Jacobsen, B.N., López de Alda, M., Ait-Aissa, S., Backhaus, T., Ginebreda, A., Hilscherová, K., Hollender, J., Hollert, H., Neale, P.A., Schulze, T., Schymanski, E.L., Teodorovic, I., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Zonja, B., Krauss, M. (2019):
Future water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures
Environ. Sci. Eur. 31 , art. 12
full text (doi) - Drozdova, P., Rivarola-Duarte, L., Bedulina, D., Axenov-Gribanov, D., Schreiber, S., Gurkov, A., Shatilina, Z., Vereshchagina, K., Lubyaga, Y., Madyarova, E., Otto, C., Jühling, F., Busch, W., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Hoffmann, S., Pörtner, H.-O., Luckenbach, T., Timofeyev, M., Stadler, P.F. (2019):
Comparison between transcriptomic responses to short-term stress exposures of a common Holarctic and endemic Lake Baikal amphipods
BMC Genomics 20 , art. 712
full text (doi) - Leuthold, D., Klüver, N., Altenburger, R., Busch, W. (2019):
Can environmentally relevant neuroactive chemicals specifically be detected with the locomotor response test in zebrafish embryos?
Environ. Sci. Technol. 53 (1), 482 - 493
full text (doi) - Schüttler, A., Altenburger, R., Ammar, M., Bader-Blukott, M., Jakobs, G., Knapp, J., Krüger, J., Reiche, K., Wu, G.-M., Busch, W. (2019):
Map and model—moving from observation to prediction in toxicogenomics
GigaScience 8 (6), giz057
full text (doi) - Serra, H., Scholze, M., Altenburger, R., Busch, W., Budzinski, H., Brion, F., Aït-Aïssa, S. (2019):
Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays
Chemosphere 227 , 334 - 344
full text (doi) - Weil, M., Mackenzie, K., Foit, K., Kühnel, D., Busch, W., Bundschuh, M., Schulz, R., Duis, K. (2019):
Environmental risk or benefit? Comprehensive risk assessment of groundwater treated with nano Fe0-based Carbo-Iron®
Sci. Total Environ. 677 , 156 - 166
full text (doi)
2018 (6)
- Altenburger, R., Scholze, M., Busch, W., Escher, B.I., Jakobs, G., Krauss, M., Krüger, J., Neale, P.A., Ait-Aissa, S., Almeida, A.C., Seiler, T.-B., Brion, F., Hilscherová, K., Hollert, H., Novák, J., Schlichting, R., Serra, H., Shao, Y., Tindall, A., Tolefsen, K.-E., Umbuzeiro, G., Williams, T.D., Kortenkamp, A. (2018):
Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays
Environ. Int. 114 , 95 - 106
full text (doi) - Beckers, L.-M., Busch, W., Krauss, M., Schulze, T., Brack, W. (2018):
Characterization and risk assessment of seasonal and weather dynamics in organic pollutant mixtures from discharge of a separate sewer system
Water Res. 135 , 122 - 133
full text (doi) - Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46
full text (doi) - Massei, R., Busch, W., Wolschke, H., Schinkel, L., Bitsch, M., Schulze, T., Krauss, M., Brack, W. (2018):
Screening of pesticide and biocide patterns as risk drivers in sediments of major European river mouths: ubiquitous or river basin-specific contamination?
Environ. Sci. Technol. 52 (4), 2251 - 2260
full text (doi) - Neale, P.A., Brack, W., Ait-Aissa, S., Busch, W., Hollender, J., Krauss, M., Maillot-Maréchal, E., Munz, N.A., Schlichting, R., Schulze, T., Vogler, B., Escher, B.I. (2018):
Solid-phase extraction as sample preparation of water samples for cell-based and other in vitro bioassays
Environ. Sci.-Process Impacts 20 (3), 493 - 504
full text (doi) - Whalley, C., Mohaupt, V., Busch, W., van den Roovaart, J., van Dujnhoven, N., Kirst, I., Schmedtje, U., Altenburger, R., Sommer, L. (2018):
Chemicals in European waters : knowledge developments
EEA Report 18/2018
Office for Official Publications of the European Communities, Luxembourg, 76 pp.
full text (doi)
2017 (6)
- Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106
full text (doi) - Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W. (2017):
Biotransformation in the zebrafish embryo – temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene
Environ. Pollut. 230 , 1 - 11
full text (doi) - Neale, P.A., Altenburger, R., Aït-Aïssa, S., Brion, F., Busch, W., De Aragão Umbuzeiro, G., Denison, M.S., Du Pasquier, D., Hilscherová, K., Hollert, H., Morales, D.A., Novák, J., Schlichting, R., Seiler, T.-B., Serra, H., Shao, Y., Tindall, A.J., Tollefsen, K.E., Williams, T.D., Escher, B.I. (2017):
Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water
Water Res. 123 , 734 - 750
full text (doi) - Neale, P.A., Munz, N.A., Aїt-Aїssa, S., Altenburger, R., Brion, F., Busch, W., Escher, B.I., Hilscherová, K., Kienle, C., Novák, J., Seiler, T.-B., Shao, Y., Stamm, C., Hollender, J. (2017):
Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams
Sci. Total Environ. 576 , 785 - 795
full text (doi) - Schmidt, S., Busch, W., Altenburger, R. (2017):
Biotestverfahren zur Abschätzung von Wirkpotenzialen in der aquatischen Umwelt : Vorschlag einer modularen Biotestbatterie für das aquatische Umweltmonitoring als Ergebnis einer systematischen Literaturrecherche und Bewertung
LUBW Landesanstalt für Umwelt Baden-Württemberg, Karlsruhe, 98 S. - Schüttler, A., Reiche, K., Altenburger, R., Busch, W. (2017):
The transcriptome of the zebrafish embryo after chemical exposure: a meta-analysis
Toxicol. Sci. 157 (2), 291 - 304
full text (doi)
2016 (3)
- Brack, W., Ait-Aissa, S., Burgess, R.M., Busch, W., Creusot, N., Di Paolo, C., Escher, B.I., Hewitt, L.M., Hilscherova, K., Hollender, J., Hollert, H., Jonker, W., Kool, J., Lamoree, M., Muschket, M., Neumann, S., Rostkowski, P., Ruttkies, C., Schollee, J., Schymanski, E.L., Schulze, T., Seiler, T.-B., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Krauss, M. (2016):
Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview
Sci. Total Environ. 544 , 1073 - 1118
full text (doi) - Busch, W., Schmidt, S., Kühne, R., Schulze, T., Krauss, M., Altenburger, R. (2016):
Micropollutants in European rivers: A mode of action survey to support the development of effect-based tools for water monitoring
Environ. Toxicol. Chem. 35 (8), 1887 - 1899
full text (doi) - Schmidt, S., Busch, W., Altenburger, R., Küster, E. (2016):
Mixture toxicity of water contaminants-effect analysis using the zebrafish embryo assay (Danio rerio)
Chemosphere 152 , 503 - 512
full text (doi)
2015 (4)
- Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barceló, D., Seiler, T.-B., Brion, F., Busch, W., Chipman, K., López de Alda, M., De Aragão Umbuzeiro, G., Escher, B.I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jäger, F., Jahnke, A., Kortenkamp, A., Krauss, M., Lemkine, G.F., Munthe, J., Neumann, S., Schymanski, E.L., Scrimshaw, M., Segner, H., Slobodnik, J., Smedes, F., Kughathas, S., Teodorovic, I., Tindall, A.J., Tollefsen, K.E., Walz, K.-H., Williams, T.D., van den Brink, P.J., van Gils, J., Vrana, B., Zhang, X., Brack, W. (2015):
Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management
Sci. Total Environ. 512-513 , 540 - 551
full text (doi) - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54
full text (doi) - Smetanová, S., Riedl, J., Zitzkat, D.P., Altenburger, R., Busch, W. (2015):
High-throughput concentration–response analysis for omics datasets
Environ. Toxicol. Chem. 34 (9), 2167 - 2180
full text (doi) - Weil, M., Meißner, T., Busch, W., Springer, A., Kühnel, D., Schulz, R., Duis, K. (2015):
The oxidized state of the nanocomposite Carbo-Iron® causes no adverse effects on growth, survival and differential gene expression in zebrafish
Sci. Total Environ. 530-531 , 198 - 208
full text (doi)