Dr. phil. Gudrun Liebscher

Postdoc in the Functional Genomics group

Contact

Department Molecular Systems Biology (MOLSYB)
Helmholtz-Zentrum für Umweltforschung - UFZ
Permoser Str. 15
04318 Leipzig

Tel: +49 341 235 1078    

GL

scientific network



Research interests


  • Proteomics
  • Proteomic analysis of the effects of plasticisers on adipocyte differentiation and function

CV


Nov 2021 - today

Postdoc
Helmholtz-Zentrum für Umweltforschung, Leipzig

2015 - 2021

PhD
Cell Biology, Biocenter, Medical Universität of Innsbruck
The LAMTOR complex is necessary for adipose tissue homeostasis

2017

Research stay
Institute for Biochemistry and Molecular cell biology, UKE Hamburg-Eppendorf

2016

Research stay
Institute for Molecular biology and Biochemistry, Medical University Graz

2012-2014

M.Sc. in Biochemistry
Martin-Luther-Universität Halle-Wittenberg
Testing of new antitumour agents on primary equine tumour cells and contributions to the elucidation of the mechanism of action

2013

Erasmus internship
Institute of Molecular Pharmacology, University of Copenhagen
Pharmacological testing of new N-benzylphenethylamines as serotonine receptor 2A - agonists

2009 - 2012

B.Sc. in Biochemistry
Martin-Luther-Universität Halle-Wittenberg
Investigation of the in vivo import of plastidic precursor proteins via EGFP fusion and BN-PAGE

Publications


2021

Cattelani C, Lesiak D, Liebscher G, Singer II, Stasyk T, Wallnöfer MH, Heberle AM, Corti C, Hess MW, Pfaller K, Kwiatkowski M, Pramstaller PP, Hicks AA, Thedieck K, Müller T, Huber LA, de Araujo MEG. The SZT2 interactome unravels new functions of the KICSTOR complex. Cells. 10 (10), 2711.


2020

Jensen AA, Halberstadt AL, Märcher-Rørsted E, Odland AU, Chatha M, Speth N, Liebscher G, Hansen M, Bräuner-Osborne H, Palner M, Andreasen JT, Kristensen JL. The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH. Biochem Pharmacol. 177:113979.

de Araújo MEG, Liebscher G, Hess MW, Huber LA. Lysosomal size matters. Traffic. 21(1):60–75.


2019

Yordanov TE, Hipolito VEB, Liebscher G, Vogel GF, Stasyk T, Herrmann C, Geley S, Teis D, Botelho RJ, Hess MW, Huber LA. Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate. Traffic. 20(9):674–96.


2018

Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J. Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. Cell Metabolism. 2018, 28(4):1-12.


2017
Jensen AA, McCorvy JD, Leth-Petersen S, Bundgaard C, Liebscher G, Kenakin TP, Brauner-Osborne H, Kehler J, Kristensen JL. Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist. J Pharmacol Exp Ther. 361:441-53.


2016

Liebscher G, Vanchangiri K, Mueller T, Feige K, Cavalleri JM, Paschke R. In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses. Chem Biol Interact. 246:20-9.


2015
Hansen M, Jacobsen SE, Plunkett S, Liebscher G, McCorvy JD, Brauner-Osborne H, Kristensen JL. Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. Bioorg Med Chem. 23:3933-7.