Dr. Micjel Chávez Morejón

Contact

Dr. Micjel Chávez Morejón
Senior Scientist

Department of Environmental Microbiology
Electrobiotechnology

Helmholtz Centre for
Environmental Research - UFZ
Permoserstr. 15, 04318 Leipzig, Germany

Phone: +49 341 235-1315
micjel.chavez-morejon@ufz.de

Dr. Micjel Chávez Morejón

Scientific Career

since October 2020

Senior Scientist at Department of Environmental Microbiology
Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany

2018 − 2020

Research Associate & Project Manager – ASM Research Chemicals GmbH

2016 − 2018

Post-doctoral Studies – Leibniz Institute of Plant Biochemistry, IPB, Halle (Saale), Germany

2012 − 2016

PhD Studies (Summa-Cum-Laude) – Leibniz Institute of Plant Biochemistry (IPB), Halle (Saale) and Martin-Luther University Halle-Wittenberg, Germany

Title: New Multicomponent Strategies to Cyclic Lipopeptides

2011 − 2016

Instructor of Organic and Biomolecular Chemistry – Faculty of Chemistry, University of Havana, Cuba

2009 − 2016

Research Associate – Center for Natural Products Research, Faculty of Chemistry, University of Havana, Cuba

2009 − 2011

M.Sc. Studies in Organic Chemistry (Distinction) – Faculty of Chemistry, University of Havana, Cuba

Research topic: Multicomponent synthesis of policationics peptidomimetics hybrids of peptide-peptoid

2006 − 2007

Internship in Biotechnological Industry – Cuban Center for Genetic Engineering and Biotechnology

2004 − 2009

Diploma Studies in Chemistry (Distinction) – Center for Natural Products Research, Faculty of Chemistry, University of Havana, Cuba

Research topic: Synthesis of peptidomimetics with potential antibacterial activity


Research interests



Peer-reviewed Publications

Morejón, M. C.; Puentes, A. R.; Rivera, D. G.; Wessjohann, L. A. Peptide Macrocyclization Assisted by Traceless Turn Inducers Derived from Ugi Peptide Ligation with Cleavable and Resin-Linked Amines. Org. Lett. 2017, 19, 4022–4025. DOI: 10.1021/acs.orglett.7b01761

Morejón, M. C.; Laub, A.; Kaluđerović, G. N.; Puentes, A. R.; Hmedat, A. N.; Otero-González, A. J.; Rivera, D. G.; Wessjohann, L. A. A Multicomponent Macrocyclization Strategy to Natural Product-Like Cyclic Lipopeptides: Synthesis and Anticancer Evaluation of Surfactin and Mycosubtilin Analogues. Org. Biomol. Chem. 2017, 15, 3628–3637. DOI: 10.1039/C7OB00459A

Morejón, M. C.; Laub, A.; Westermann, B.; Rivera, D. G.; Wessjohann, L. A. Solution and Solid-Phase Macrocyclization of Peptides by the Ugi-Smiles Multicomponent Reaction: Synthesis of N-Aryl-Bridged Cyclic Lipopeptides. Org. Lett. 2016, 18 (16), 4096–4099. DOI: 10.1021/acs.orglett.6b02001

Wessjohann, L. A.; Morejón, M. C.; Ojeda, G. M.; Rhoden, C. R. B.; Rivera, D. G. Applications of Convertible Isonitriles in the Ligation and Macrocyclization of Multicomponent Reaction-Derived Peptides and Depsipeptides. J. Org. Chem. 2016, 81 (15), 6535–6545. DOI: 10.1021/acs.joc.6b01150

Neves, R. A. W.; Stark, S.; Morejón, M. C.; Westermann, B.; Wessjohann, L. A. 4-Isocyanopermethylbutane-1,1,3-triol (IPB): a convertible isonitrile for multicomponent reactions. Tetrahedron Letters 2012, 53 (40), 5360-5363. Highlighted in: Chem Inform 2013, 44, 0520. DOI: 10.1016/j.tetlet.2012.07.064


Book Chapters

Wessjohann, L. A.; Neves Filho, R. A.; Puentes, A. R.; Morejón, M. C. Macrocycles from Multicomponent Reactions, In Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies, Eds. Marsault, E.; Peterson, M. L. Wiley-Blackwell, 2017, pp 339.

Wessjohann, L. A.; Neves Filho, R.A.W.; Puentes, A.R.; Morejón, M.C. Macrocycles from Multicomponent Reactions, In Multicomponent Reactions in Organic Synthesis, 1st Edition. Zhu, J.; Wang, Q.; Wang, M. Eds. Wiley-VCH Verlag GmbH & Co. KGaA, 2015, pp 231.

Wessjohann, L. A.; Kaluderovic, G.; Neves Filho, R.A.W.; Morejón, M.C.; Lemanski, G.; Ziegler, T. Ed. Müller T.J.J. Multicomponent reactions 1. In Science of Synthesis, 2013, pp 415.

  • Morejón, M.C.; Neves Filho, R.A.W.; Puentes, A.R.; Westermann, B.; Wessjohann, L. A.; PS-IPB as a new resin-immobilized convertible isonitrile for multicomponent reactions. At 6th International Conference on Multi-Component Reactions and Related Chemistry (MCR 2015), Brasilia, Brazil
  • Morejón, M.C.; Neves Filho, R.A.W.; Stark, S.; Rivera, D.G.; Westermann, B.; Wessjohann, L. A.; Total synthesis of Spiroidesin a homotyrosine-containing lipopeptide. At 18th European Symposium on Organic Chemistry (ESOC 2013), Marseille, France. Poster presentation