Dr. Clarisa Santamaria
Contact
Dr. Clarisa Santamaria
Scientist
Helmholtz Centre for
Environmental Research – UFZ
Department of Environmental Immunology
Permoserstr. 15
04318 Leipzig, Germany
Email
Research Interests
- Influence of hCG on the modulation of immune responses during the implantation process using human/mouse in vitro and in vivo models with focus on regulatory T cells and dendritic cells
- Impact of perinatal exposure to endocrine disruptor chemicals on pregnancy and the influence on reproductive and fertility parameters of the offspring
Curriculum vitae / Scientific career
Since 09/2020
Scientist, Department of Environmental Immunology, Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
2017
Theoretical and practical assistant, Isolation of sperms and oocytes followed by in vitro fertilization, Interdisciplinary Autumn School for Reproductive Sciences and related Research Fields, Magdeburg, Germany
2016 - 2019
Postdoctoral position, Instituto de Salud y Ambiente del Litoral” (ISAL), National University of Litoral (UNL) - National Scientific and Technical Research Council (CONICET), Research field: Gonadal toxicology and gestational immune response, Principal investigator: Prof. Dr. Horacio Adolfo Rodríguez Santa Fe, Argentina
2014, 2016
Theoretical and practical assistant, Laboratory animal experimental models, School of Biochemistry and Biological Sciences, National University of Litoral, Santa Fe, Argentina
2014 - 2019
Practical work training, Department of Human Physiology, School of Biochemistry and Biological Sciences, National University of Litoral, Santa Fe, Argentina
2012 - 2014
Practical assistant, Department of Human Physiology, School of Biochemistry and Biological Sciences, National University of Litoral, Santa Fe, Argentina
2011 - 2016
PhD in Biological Sciences, National University of Litoral, School of Biochemistry and Biological Sciences, Santa Fe, Argentina
2010
Clinical Biochemistry, Blood analyses in pediatric patientes, Area: Child department of the Sanatorio Diagnóstico, Head of the laboratory: Biochemist Azucena Mondino and Maria Rosa Migone, Santa Fe, Argentina
2003 - 2011
Biochemist, National University of Litoral, School of Biochemistry and Biological Sciences, Santa Fe, Argentina
Awards and grants
2017
Distinction to the most cited paper of the year 2016 in the journal “Reproduction”, Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs, UNL, Santa Fe, Argentine
2016 - 2019
Postdoctoral fellowship, National Scientific and Technical Research Council (CONICET), Santa Fe, Argentina
2014 - 2016
Doctoral fellowship type 2, National Scientific and Technical Research Council (CONICET), Santa Fe, Argentina
2011 - 2014
Doctoral fellowship type 1, National Scientific and Technical Research Council (CONICET), Santa Fe, Argentina
Publications
2020 Santamaria, C.G., Meyer, N., Schumacher, A., Zenclussen, M.L., Teglia, C.M., Culzoni, M.J., Zenclussen, A.C:, Rodriguez, H.A., Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice, Arch Toxicol (2020). doi: 10.1007/s00204-020-02776-5.
2019 Santamaria, C.G., Abud, J.E., Luque, E.H., Kass, L., Rodriguez, H.A., Culturing rat whole ovary for UV filter benzophenone-3 treatment, Current Protocols in Toxicology, 82, e89.doi:10.1002/cptx.89.
2019 Meyer, N., Santamaria, C. Guillermina, Müller, J. Elisabeth, Schumacher, A., Rodriguez, H. Adolfo, Zenclussen, A. Claudia., Exposure to 17-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice, Environmental pollution, 251, 493-501. doi: 10.1016/j.envpol.2019.04.144.
2019 Carla M. Teglia, Clarisa G. Santamaría, Horacio A. Rodríguez, María J. Culzoni, Héctor C. Goicoechea, Determination of 2-hydroxy-4-methixybenzophenone in mice serum and human plasma by ultra-hich-performance liquid chromatography enhanced by chemometrics, Microchemical Journal, 148, 35-41 doi: 10.1016/j.microc.2019.04.032.
2019 J.E.Abud, C.G.Santamaría, M.Oggero, H.A.Rodriguez, Methodological aspects of universal immuno-PCR on standard tubes, Analytical Biochemistry, 570, 56-61. doi: 10.1016/j.ab.2019.02.007.
2019 Santamaría CG, Abud JE, Porporato MM, Meyer N, Zenclussen AC, Kass L, Rodríguez HA, The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures, Toxicol Lett. 2019;303:48-54. doi:10.1016/j.toxlet.201 8.12.016.
2018 Müller JE, Meyer N, Santamaria CG, Schumacher A, Luque EH, Zenclussen ML, Rodríguez HA, Zenclussen AC, Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice, Sci Rep.2018;8(1):9196.doi:10.1038/s41598-018-27575-y.
2017 Abud JE, Santamaría C, Luque EH, Rodríguez H, Development of quantitative immuno-polymerase chain reaction assay to detect and quantify human thyroid stimulating hormone, Anal Biochem. 2017 Dec 15;539:134-143. doi: 10.1016/j.ab.2017.10.023.
2017 Santamaría CG, Rodriguez HA, Abud JE, Rivera OE, Muñoz-de-Toro M, Luque EH, Impaired ovarian response to exogenous gonadotropins in female rat offspring born to mothers perinatally exposed to Bisphenol A (BPA), Reprod Toxicol. 2017 Oct;73:259-268. doi: 10.1016/j.reprotox.2017.06.050.
2017 Santamaría CG, Rodriguez HA, Abud JE, Rivera OE, Muñoz-de-Toro M, Luque EH, Impaired ovarian response to exogenous gonadotropins in female rat offspring born to mothers perinatally exposed to Bisphenol A (BPA), Reprod Toxicol. 2017 Oct;73:259-268. doi: 10.1016/j.reprotox.2017.06.050.
2016 Santamaría CG, Durando M, Muñoz de Toro M, Luque EH, Rodríguez, Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of Bisphenol A, J Steroid Biochem Mol Biol. 2016 Apr;158:220-30. doi:10.1016/j.jsbmb.2015.11.016.
2015 Porro V, Pagotto R, Harreguy MB, Ramírez S, Crispo M, Santamaría C, Luque EH, Rodríguez HA, Bollati-Fogolín M, Characterization of Oct4-GFP transgenic mice as a model to study the effect of environmental estrogens on the maturation of male germ cells by using flow cytometry, J Steroid Biochem Mol Biol. 2015 Jul 4. pii: S0960-0760(15)30006-6. doi:10.1016/j.jsbmb.2015.06.006.
2015 Rivera OE, Varayoud J, Rodríguez HA, Santamaría CG, Bosquiazzo VL, Osti M, Belmonte NM, Muñoz-de-Toro M, Luque EH, Neonatal exposure to xenoestrogen impairs the ovarian response to gonadotropin treatment in lambs, Reproduction. 2015 Jun;149(6):645-55.doi:10.1530/REP-14-0567.
2010 Rodríguez H, Santambrosio N, Santamaría C, Muñoz-de-Toro M, Luque EH, Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary, Reprod Toxicol. 2010 Dec;30(4):550-7. doi: 10.1016/j.reprotox.2010.07.008.