Alexandra Schaffert, M.Sc.

PhD student in the group of Functional Genomics

Contact

Department of Molecular

Systems Biology
Helmholtz Centre
for Environmental Research
Permoserstr. 15
04318 Leipzig, Germany

Phone: 0341 235 1078
alexandra.schaffert@ufz.de

Alexandra Schaffert

Focus of Research


The pathogenesis of obesity and -related comorbidities has been shown to be affected by environmental factors. Particularly plasticizers can drive obesogenic effects. Plasticizers can disrupt endocrine functions, like the differentiation of adipocytes in adipose tissue. This process is substantially controlled by the peroxisome proliferator-activated receptor γ (PPARγ). In the last years it was reported that besides binding of natural ligands like prostaglandin, a number of phthalates from the group of plasticizers are able to activate the PPARγ. By processing in consumer-related plastic products, plasticizers are ubiquitary distributed in the environment, which may affect humans as well as aquatic organisms. To overcome the artificial separation of human and ecological toxicology, the molecular interactions underlying the obesogenic and therefore health-damaging effects of plasticizers in humans and zebrafish will be investigated.


Curriculum Vitae


Since Feb 2018

PhD student with a doctoral scholarship from the German Federal Environmental Foundation (DBU) in the Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig

Oct 2017 -

Jan 2018

Scientific assistant in the Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig

Oct 2015 -

Sep 2017

Master of Science in Biochemistry with the focus on Molecular Biochemistry/Bioanalytics at the University of Leipzig

Apr 2012 -

Apr 2015

Bachelor of Science in Molecular Biology at the Johannes Gutenberg-University of Mainz