Experimental Allergy and Immunology

Helmholtz University Research Group "Experimental Allergy and Immunology (EIA)"

Research Topics

The prevalence of allergic diseases has risen rapidly in the last two decades, especially in industrialized countries. Epidemiological studies offer increasing evidence that exposure to environmental pollutants is associated with the development of allergic diseases. In colaboration with the Leipzig University our Reserach Group investigates the role of environmental chemicals as risk factors for the development of allergic asthma or other immune diseases. Using a transgenerational mouse model we are in particular interested to what extent maternal exposure to chemicals affects the disease risk in the offspring. These findings may contribute to identify crucial disease risks and to develope new prevention strategies.

Selected Publications

Jahreis S, Trump S, Bauer M, Bauer T, Thürmann L, Feltens R, Wang Q, Gu L, Grützmann K, Röder S, Averbeck M, Weichenhan D, Plass C, Sack U, Borte M, Dubourg V, Schüürmann G, Simon JC, von Bergen M, Hackermüller J, Eils R, Lehmann I, Polte T (2017). Maternal phthalate exposure promotes allergic airway inflammation over two generations via epigenetic modifications. J Allergy Clin Immunol doi: 10.1016/j.jaci.2017.03.017 Abstract Press Release
Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon JC, Lehmann I, Echtermeyer F, Pap T, Averbeck M. Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation. Nat Commun. 2015 Jul 13;6:7554 Abstract Press Release

Reiprich M, Rudzok S, Schütze N, Simon JC, Lehmann I, Trump S, Polte T. Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. Allergy. 2013 Apr;68(4):481-9 Abstract
Schütze N, Lehmann I, Bönisch U, Simon JC, Polte T. Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med 181: 1188-1199. Cover Press Release
Polte T, Hennig C, Hansen G. Allergy prevention starts before conception: Maternofetal transfer of tolerance protects from the development of asthma. J Allergy Clin Immunol. 2008 Nov;122(5):1022-1030.e5 Abstract
Polte T, Behrendt AK, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006 Oct;118(4):942-8 Abstract
Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G. CD137-mediated immunotherapy for allergic asthma. J Clin Invest. 2006 Apr;116(4):1025-36 Abstract