Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1080/10256019908234085 |
| Title (Primary) | Application of deuterated compounds for investigations of percutaneous absorption of chemical substances |
| Author | Kietzmann, M.; Kränke, P.; Möder, M.; Schrader, S.; Wahren, M. |
| Source Titel | Isotopes in Environmental and Health Studies |
| Year | 1999 |
| Department | ANA |
| Volume | 35 |
| Issue | 1-2 |
| Page From | 127 |
| Page To | 134 |
| Language | englisch |
| Abstract | The percutaneous absorption of the xenoestrogen 2,2-bis-(4-hydroxyphenyl)-propane (bisphenol A) 1 has been studied and compared with results on dibenzoyl peroxide 2, a component of drug formulations for topical application. Isolated perfused bovine udders from slaughtered cows were employed as models for human skin. The deuterium labelled compounds 1-d14 and 2-d10 were applied to enhance the reliability of GC-MS trace determinations by use of reverse isotope dilution analysis. 1-d14 was found in perfusate and milk equivalent samples obtained between 60 and 300 min after topical application with maximum concentrations between 120 and 180 min. 1-d14 was enriched in the milk samples by a factor of about 300 compared with the perfusate. The results confirm a possible penetration of 1 from the environment through the skin into the capillary system. 2 studied on the same model system penetrated faster than 1 by a factor of about three. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=8094 |
| Kietzmann, M., Kränke, P., Möder, M., Schrader, S., Wahren, M. (1999): Application of deuterated compounds for investigations of percutaneous absorption of chemical substances Isot. Environ. Health Stud. 35 (1-2), 127 - 134 10.1080/10256019908234085 |
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