Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/S0041-1345(01)02025-5
Title (Primary) The monoclonal anti-CD4 antibody RIB5/2 induces donor-specific tolerance in the high-responder liver transplant model in the rat
Author Kohlhaw, K.; Sack, U.; Lehmann, I.; Drews, G.; Hartwig, T.; Tannapfel, A.; Berr, F.; Oertel, M.; Marx, U.; Lehmann, M.; Hauss, J.; Emmrich, F.
Source Titel Transplantation Proceedings
Year 2001
Department IMMU
Volume 33
Issue 3
Page From 2371
Page To 2373
Language englisch
Abstract T-helper cells expressing the CD4 molecule on their cell surface play a central role in alloantigen recognition and consecutive induction of a rejection process. In experimental models, presence of CD4+ cells was elementary for induction of the rejection process.1 Accordingly, this lymphocyte subpopulation showed an increased expression of IL-2 receptor, indicating their activated state.2 By use of a monoclonal anti-CD4 antibody (Mab) the rejection process could be reversed by negatively influencing the toxicity of effector cells and/or their migration into the graft by the lack of CD4+ cells.3 In addition, antibodies directed against the CD4 epitope were shown to induce donor-specific tolerance in high-responder transplant models (kidney,4 and heart)5 in the rat. In this study, we examine the effectiveness of the nondepleting anti-CD4 MAb RIB5/2 in the liver transplant model.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=6513
Kohlhaw, K., Sack, U., Lehmann, I., Drews, G., Hartwig, T., Tannapfel, A., Berr, F., Oertel, M., Marx, U., Lehmann, M., Hauss, J., Emmrich, F. (2001):
The monoclonal anti-CD4 antibody RIB5/2 induces donor-specific tolerance in the high-responder liver transplant model in the rat
Transplant. Proc. 33 (3), 2371 - 2373 10.1016/S0041-1345(01)02025-5