Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/S0041-1345(01)01931-5
Title (Primary) Anti-CD4-induced long-term acceptance of rat liver allografts in a high-responder model is not based on pure immunosuppression
Author Kohlhaw, K.; Sack, U.; Lehmann, I.; Drews, G.; Schwarz, R.; Hartwig, T.; Tannapfel, A.; Berr, F.; Oertel, M.; Marx, U.; Lehmann, M.; Witterkind, C.; Hauss, J.; Emmrich, F.
Source Titel Transplantation Proceedings
Year 2001
Department IMMU
Volume 33
Issue 3
Page From 2173
Page To 2175
Language englisch
Abstract In alloantigen recognition and consecutive induction of a rejection process, T-helper cells expressing the CD4 molecule on their cell surface play a central role. Presence of CD4+ cells was elementary for the induction of the rejection process1 in experimental models. Monoclonal anti-CD4 antibodies (mab) have been shown to have not only an immunosuppressive, but also an immunomodulative effect by inducing donor-specific tolerance in a high-responder renal2 or heart3 transplant models. Recently we could show that the anti-CD4 mab RIB5/2 was able to induce donor-specific tolerance of a transplanted liver in a high-responder liver transplant model [Dark Agouti (DA) → Lewis (LEW)].4 Although this anti-CD4 mab is suggested to be nondepleting in renal and heart transplant models,5 in the liver transplant model its behavior seems to be different since after RIB5/2 therapy and liver transplantation, CD4+ cells were eliminated from the peripheral blood for several days.4 To learn more about the potency of the anti-CD4 mab RIB5/2 in the liver transplant model, the aim of this study was to evaluate the impact of an additional blockade of a costimulatory pathway (LFA-1) together with an insufficient dose of the anti-CD4 mab. Furthermore, we tried to discriminate between immunomodulation and immunosuppression.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=6512
Kohlhaw, K., Sack, U., Lehmann, I., Drews, G., Schwarz, R., Hartwig, T., Tannapfel, A., Berr, F., Oertel, M., Marx, U., Lehmann, M., Witterkind, C., Hauss, J., Emmrich, F. (2001):
Anti-CD4-induced long-term acceptance of rat liver allografts in a high-responder model is not based on pure immunosuppression
Transplant. Proc. 33 (3), 2173 - 2175 10.1016/S0041-1345(01)01931-5