Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| URL | http://www.wjgnet.com/1007-9327/10/3056.asp |
| Title (Primary) | Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population |
| Author | Fan, L.Y.; Tu, X.Q.; Cheng, Q.B.; Zhu, Y.; Feltens, R.; Pfeiffer, T.; Zhong, R.Q. |
| Source Titel | World Journal of Gastroenterology |
| Year | 2004 |
| Department | IMMU |
| Volume | 10 |
| Issue | 20 |
| Page From | 3056 |
| Page To | 3059 |
| Language | englisch |
| Abstract | AIM: To investigate the association between Chinese patients with autoimmune
hepatitis (AIH), primary biliary cirrhosis (PBC) and the polymorphisms of
cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene promoter (-318) and
exon 1 (+49). METHODS: CTLA-4 promoter (-318 T/C) and exon1 (+49A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 62 Chinese AIH patients, 77 Chinese PBC patients and 160 healthy controls. RESULTS: We found a significant association in CTLA-4 gene exon1 49 A/G polymorphism between PBC patients and controls (P = 0.006) and the frequency of G alleles was significantly increased in comparison with controls (P = 0.0046, OR = 1.8). We also found the frequency of C alleles in promoter -318 was significantly increased in AIH patients compared with controls (P = 0.02, OR = 0.41). Although the genotype distribution of the CTLA-4 exon 1-promoter gene was not significantly different between AIH and PBC patients and controls, the occurence of GG-CC was increased in two groups of patients (AIH: 32.3%, PBC: 37.7%, control: 22.5%). CONCLUSION: Polymorphisms of CTLA-4 gene probably confer susceptibility to AIH and PBC in Chinese population. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=4058 |
| Fan, L.Y., Tu, X.Q., Cheng, Q.B., Zhu, Y., Feltens, R., Pfeiffer, T., Zhong, R.Q. (2004): Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population World J. Gastroenterol. 10 (20), 3056 - 3059 |
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