Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.chemosphere.2012.07.069
Title (Primary) Liposome and protein–water partitioning of polybrominated diphenyl ethers (PBDEs)
Author Endo, S.; Mewburn, B.; Escher, B.I.
Source Titel Chemosphere
Year 2013
Department AUC
Volume 90
Issue 2
Page From 505
Page To 511
Language englisch
Keywords brominated flame retardants; bioaccumulation; polymer depletion; membrane affinity; serum albumin binding
UFZ wide themes RU3;
Abstract

Bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine and terrestrial organisms is of great environmental concern. Understanding the partitioning of PBDEs to biological phases is crucial for elucidating their bioaccumulation behavior. In this study, partitioning coefficients of PBDEs from water to phospholipid liposomes (Klipw) and to bovine serum albumin (BSA) (KBSAw) were measured using a polymer depletion method. Klipw values measured in two laboratories are in an excellent agreement (within 0.14 log units), indicating a high method repeatability. The values of log Klipw and log KBSAw are in the range of 6.3–8.2 and 5.1–7.0, respectively, representing the highest of these partition coefficients measured to date. Log Klipw values for PBDEs are similar to the log of the octanol–water partition coefficients (Kow) (log Klipw − log Kow = −0.06 ± 0.23; mean ± SD of 7 congeners), consistent with the data of chlorobenzenes and polychlorinated biphenyls (PCBs) reported in the literature. No hydrophobicity cutoff was observed for partitioning to the liposome membrane. Log KBSAw values for PBDEs increase linearly with log Kow and do not follow the non-linear trend observed for polycyclic aromatic hydrocarbons (PAHs). This difference between PBDEs and PAHs suggests specific binding mechanisms to serum albumin even for hydrophobic compounds.


Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12786
Endo, S., Mewburn, B., Escher, B.I. (2013):
Liposome and protein–water partitioning of polybrominated diphenyl ethers (PBDEs)
Chemosphere 90 (2), 505 - 511 10.1016/j.chemosphere.2012.07.069