Dr. Isabel Karkossa
(Née Kratochvil)
Postdoc in der Functional Genomics Gruppe
Kontakt
Department Molekulare Systembiologie (MOLSYB)
Helmholtz-Zentrum für Umweltforschung - UFZ
Permoser Str. 15
04318 Leipzig
Tel: 0341 - 235 482453
isabel.karkossa@ufz.de
ResearchGate

Forschungsschwerpunkte
- Systembiologische Analyse der modes of action von Schadstoffen in Immunzellen
Proteomics
Lebenslauf
2019 - heute
Postdoc
Helmholtz-Zentrum für Umweltforschung, Leipzig
2016 - 2019
Doktorarbeit
Helmholtz-Zentrum für Umweltforschung, Leipzig
Proteomics zur Bewertung von Nanomaterialien entsprechend ihrer Wirkung
2015
Forschungsaufenthalt
Vanderbilt University, Nashville, TN, USA
Untersuchung von Biomolekülen mittels Ionenmobilitäts-Massenspektrometrie
2014 - 2016
Masterstudium Biochemie
Universität Leipzig, Schwerpunkt Biomedizin
Untersuchung von Interaktionen des PPARγ mit Phthalaten mittels HDX-MS
2011 - 2014
Bachelorstudium Biochemie
Martin-Luther-Universität Halle-Wittenberg
Evaluierung eines MS/MS-spaltbaren Crosslinkers zur 3D-Strukturvorhersage von Proteinen
Publikationen
2021 (3)
- Großkopf, H., Walter, K., Karkossa, I., von Bergen, M., Schubert, K., (2021):
Non-genomic AhR-signaling modulates the immune response in endotoxin-activated macrophages after activation by the environmental stressor BaP
Front. Immunol. 12 , art. 620270
Volltext (DOI) - Monikh, F.A., Chupani, L., Karkossa, I., Gardian, Z., Arenas-Logo, D., von Bergen, M., Schubert, K., Piackova, V., Zuskova, E., Jiskoot, W., Vijver, M.G., Peijnenburg, W.J.G.M., (2021):
An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes
NanoImpact
Volltext (DOI) - Streidl, T., Karkossa, I., Segura Muñoz, R.R., Eberl, C., Zaufel, A., Plagge, J., Schmaltz, R., Schubert, K., Basic, M., Schneider, K.M., Afify, M., Trautwein, C., Tolba, R., Stecher, B., Doden, H.L., Ridlon, J.M., Ecker, J., Moustafa, T., von Bergen, M., Ramer-Tait, A.E., Clavel, T., (2021):
The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice
Gut Microbes 13 (1), 1 - 21
Volltext (DOI)
2020 (5)
- Bannuscher, A., Karkossa, I., Buhs, S., Nollau, P., Kettler, K., Balas, M., Dinischiotu, A., Hellack, B., Wiemann, M., Luch, A., von Bergen, M., Haase, A., Schubert, K., (2020):
A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages
Nanotoxicology 14 (2), 181 - 195
Volltext (DOI) - Hsu, M.-J., Karkossa, I., Schäfer, I., Christ, M., Kühne, H., Schubert, K., Rolle-Kampczyk, U.E., Kalkhof, S., Nickel, S., Seibel, P., von Bergen, M., Christ, B., (2020):
Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH
Biomedicines 8 (9), art. 350
Volltext (DOI) - Karkossa, I., Raps, S., von Bergen, M., Schubert, K., (2020):
Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Int. J. Mol. Sci. 21 (24), art. 9371
Volltext (DOI) - Leppert, B., Strunz, S., Seiwert, B., Schlittenbauer, L., Schlichting, R., Pfeifer, C., Röder, S., Bauer, M., Borte, M., Stangl, G.I., Schöneberg, T., Schulz, A., Karkossa, I., Rolle-Kampczyk, U.E., Thürmann, L., von Bergen, M., Escher, B.I., Junge, K.M., Reemtsma, T., Lehmann, I., Polte, T., (2020):
Maternal paraben exposure triggers childhood overweight development
Nat. Commun. 11 , art. 561
Volltext (DOI) - Wang, Z., Karkossa, I., Großkopf, H., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K., (2020):
Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP
Toxicology 448 , art. 152652
Volltext (DOI)
2019 (4)
- Karkossa, I., Bannuscher, A., Hellack, B., Bahl, A., Buhs, S., Nollau, P., Luch, A., Schubert, K., von Bergen, M., Haase, A., (2019):
An in-depth multi-omics analysis in RLE-6TN rat alveolar epithelial cells allows for nanomaterial categorization
Part. Fibre Toxicol. 16 (1), art. 38
Volltext (DOI) - Kratochvil, I., Bannuscher, A., Hellack, B., von Bergen, M., Haase, A., Schubert, K., (2019):
Nanomaterials affect oxidative phosphorylation and phagocytosis in alveolar macrophages
Eur. J. Immunol. 49 (Suppl. 1), 232
Volltext (DOI) - Kratochvil, I., Hofmann, T., Rother, S., Schlichting, R., Moretti, R., Scharnweber, D., Hintze, V., Escher, B.I., Meiler, J., Kalkhof, S., von Bergen, M., (2019):
Mono(2‐ethylhexyl) phthalate (MEHP) and mono(2‐ethyl‐5‐oxohexyl) phthalate (MEOHP) but not di(2‐ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator‐activated receptor γ
Rapid Commun. Mass Spectrom. 33 (S1), 75 - 85
Volltext (DOI) - Schubert, K., Schor, J., Kratochvil, I., Hackermüller, J., von Bergen, M., (2019):
Multi-omics profiling of MAIT cells reveals specific patterns of antigen-dependent and -independent activation
Eur. J. Immunol. 49 (Suppl. 1), 141
Volltext (DOI)
2018 (1)
- May, J.C., Jurneczko, E., Stow, S.M., Kratochvil, I., Kalkhof, S., McLean, J.A., (2018):
Conformational landscapes of ubiquitin, cytochrome c, and myoglobin: Uniform field ion mobility measurements in helium and nitrogen drift gas
Int. J. Mass Spectrom. 427 , 79 - 90
Volltext (DOI)
- Ihling, C., Falvo, F., Kratochvil, I., Sinz, A., & Schäfer, M. (2015). Dissociation behavior of a bifunctional tempo-active ester reagent for peptide structure analysis by free radical initiated peptide sequencing (FRIPS) mass spectrometry. J Mass Spectrom, 50(2), 396-406
Poster & Talks
Kratochvil, I., Bannuscher, A., Hellack, B., Haase A., Schubert, K., von Bergen, M. (2019). Multi-Omics to Develop Nanomaterial Grouping Strategies for Risk Assessment. Poster presented at Proteomic Forum, Potsdam, Germany.
Kratochvil, I., Bannuscher, A., Kettler, K., Haase A., von Bergen, M., Schubert, K. (2018). Weighted Gene Correlation Network Analysis to develop nanomaterial grouping strategies. Talk at 9th International Conference on Nanotoxicology, Neuss, Germany.
Kratochvil, I., Bannuscher, A., Kettler, K., Haase A., Schubert, K., von Bergen, M. (2018). Weighted Gene Correlation Network Analysis as Grouping Strategy for Nanomaterial Risk Assessment in Alveolar Macrophages. Poster presented at European Mass Spectrometry Conference, Saarbrücken, Germany.
Kratochvil, I., Bannuscher, A., Haase A., Schubert K., von Bergen, M. (2018). Weighted Gene Correlation Network Analysis as Grouping Strategy for Nanomaterial Risk Assessment. Poster presented at Research Festival, Leipzig, Germany.
Kratochvil, I., Hofmann, T., Schlichting R., Escher E., Kalkhof, S., von Bergen, M. (2017). MEHP and MEOHP but not DEHP bind and activate the peroxisome proliferator-activated receptor γ. Poster presented at meeting of German Society of Mass Spectrometry, Kiel, Germany.