Jannike Lea Krause


Jannike Lea Krause

Doktorandin in der Arbeitsgruppe “Immunregulation und Umweltfaktoren”

Department Umweltimmunologie
Helmholtz-Zentrum für Umweltforschung – UFZ
Permoserstr. 15
04318 Leipzig

Tel.: +49 341 235-1542

Jannike Lea Krause
Foto: Sebastian Wiedling/UFZ

Research Interests

  • Immune modification by the microbiome and the influence of chemicals on microbial communities

  • Usability of model systems to investigate the effect of environmental chemicals on gut microbiota

  • Identification of microbiota-mediated and direct immune modulatory properties of chemicals with focus on mucosal-associated invariant T cells (MAIT cells)

Curriculum vitae / Scientific career

since 01/2017

PhD student at the Department of Environmental Immunology at the Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany
Thesis: "Analysis of the influence of Glyphosate with regard to microbiome mediated effects on specialized immune cells, the mucosal invariant T cells (MAIT cells)"

since 10/2015

Postgraduate study of Toxicology and Environmental protection at the University of Leipzig

05/2013 - 08/2013

University Medical Center Hamburg-Eppendorf (UKE), Department of Molecular Biology
Project assistant - pre-investment study: "Dependence of the N-linked glycosylation of the GlcNAc-1-phosphotransferase for the proteolytic activation with the Site-1-protease"

01/2012 - 12/2014

Nordische Ölwerke Walther Carroux GmbH & Co. KG
Laboratory assistant - quality control oleochemicals

08/2011 - 10/2011

Research Center Borstel - Leibniz-Center for Medicine and Bioscineces, Department of Biophysics
Project assistant - pre-investment study: "Visualisation of the effect of antimicrobial peptides (AMP) to different cancer cell lines and permeabilisation of LUV with AMP"

08/2010 - 08/2011

University of Hamburg, Department of Biochemistry
Project assistant - pre-investment study: "Filtration and crystallisation of the superoxide dismutase of Onchocerca volvulus"

10/2009 - 06/2015

Study of Molecular Life Sciences at the University of Hamburg

Bachelor of Science at the Department of Plant Molecular Biology at the University of Hamburg (2012)

Master of Science at the Department of Immunology at the Bernhard Nocht Institute for Tropical Medicine (2015)
Thesis: "Analysis concerning the influence of programmed death ligand-1 (PD-L1) in CD8+ T cell stimulation"

02/2008 - 04/2009

mibe GmbH Arzneimittel
Laboratory assistant - quality control microbiology

08/2004 - 08/2006

Bernd-Blindow-Schulen gGmbH, Leipzig
Technical assistant for chemical and biological laboratories (BCTA)


01/2017 - 12/2019    Doctoral scholarship of the German Environmental Foundation (DBU)


Krause JL*, Schaepe SS*, Fritz-Wallace K, Engelmann B, Rolle-Kampczyk U, Kleinsteuber S, Schattenberg F, Liu Z, Mueller S, Jehmlich N, von Bergen M#, Herberth G# (2020): Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use. Gut Microbes. (*#equal contribution). Abstract

Anne Mendler, Florian Geier, Sven-Bastiaan Haange, Arkadiusz Pierzchalski, Jannike Lea Krause, Ivonne Nijenhuis, Jean Froment, Nico Jehmlich, Urs Berger, Grit Ackermann, Ulrike Rolle-Kampczyk , Martin von Bergen & Gunda Herberth (2020): Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria. Journal of Immuntoxicology. Abstract

Katarina Fritz-Wallace*, Beatrice Engelmann*, Jannike L. Krause, Stephanie S. Schäpe, Judith Pöppe, Gunda Herberth, Uwe Rösler, Nico Jehmlich, Martin v. Bergen, Ulrike Rolle-Kampczyk (2019): Quantification of glyphosate and AMPA from microbiome reactor fluids. Rapid Communications in Mass Spectrometry. Abstract (*equal contribution).

Schaepe SS*, Krause JL*, Fritz-Wallace K, Engelmann B, Rolle-Kampczyk U, Kleinsteuber S, Schattenberg F, Liu Z, Mueller S, Jehmlich N, Herberth G#, von Bergen M# (2019): The simplified human intestinal microbiota (SIHUMIx) shows high structural and functional resistance against changing transit times in in vitro bioreactors. Microorganisms. Abstract (*#equal contribution).

Gross S, Wilms D, Krause J, Brezesinski G, Andrä J. (2013): Design of NK-2-derived peptides with improved activity against equine sarcoid cells. J. Pept. Sci.; 19: 619-628.

Banković J*, Andrä J*, Todorović N, Ana P-R, Đorđe M, Krause J, Ruždijić S, Tanić N, Pešić M. (2013): The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation.
Exp. Cell Res:; 319: 1013-1027. *equal contribution