Dr. Eberhard Küster

Dr. Eberhard Küster
Foto: Sebastian Wiedling/UFZ

Adresse:
Permoserstr. 15
04318 Leipzig

Gebäude: 6.0
Raum: 325
Telefon: +49 341 235 1525

Dr. Eberhard Küster

Curriculum Vitae

Eberhard Küster was trained as a Biological-Technical Assistant at the „Regional Office for Fishery in North Rhine -Westphalia“ i.e. Landesanstalt für Fischerei, Nordrhein-Westfalen Germany from 1987 to 1989. He got his diploma in biology after studying Biology and Marine Biology at the University of Marburg, Germany, the Juniata College (Pennsylvania, USA), the Duke University Marine Laboratory, Beaufort (NC, USA) and the University of Rostock, Germany (Supervisor Karl Jürß) from '89 to '96. He received his PhD (Dr. rer. nat.) from the University of Tübingen, Germany in the Department of Pharmacology and Toxicology in the year 2000 (Supervisor Bernd Mühlbauer). From 2000 to 2010 he held several PostDoc positions in the Departments Chemical Ecotoxicology and Bioanalytical Ecotoxicology at the Helmholtz Centre for Environmental Research – UFZ in the research areas of groundwater remediation evaluation, biomarker development and hazard assessment with different bioassays. Since 2010 he works as a research associate at the Dept. Bioanalytical Ecotoxicology of the UFZ and is the head of the work group „Stress Physiology“. In 2013 E. Küster received a fellowship award by the OECD Co-operative Research Programme: Biological Resource Management for Sustainable Agricultural Systems in 2013 for research at the NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA (Marie DeLorenzo and Mike Fulton lab). Currently he also holds a teaching assignment at the Technical University Bergakademie Freiberg.

The research interests broadly include two topics which are ancillary to the general goal of further upgrading of zebrafish embryos (Danio rerio) as an alternative for animal testing (DarT) for risk assessment of substances with specific and unspecific mode of action (lipophilic/ volatile substances, pharmaceuticals, genotoxins). First, the determination of the internal dose over time as a measure for the effective concentration is in focus to better understand physiologically-based toxicokinetics (PBTK). Secondly, the effects of single substances and mixtures thereof on fish embryos are observed on different sublethal levels with a major focus on the analysis of the proteome (Ecotoxicoproteomics) as a tool to identify important sublethal stress effects and primary and higher level reactions (close cooperation with the Dept. Proteomics at the UFZ). Chemical analysis of the internal concentrations is mainly done with LC and GC methods and also in close cooperation with the Analytics Department of the UFZ (T. Reemtsma).

Recent third party funded project: NeuroBox includes the effect directed identification & the single and mixture analysis of neuroactive drinking water contaminants with the acute Danio rerio fish embryo assay on different effect levels.

Publikationen

2017 (2)

  • Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W., (2017):
    Biotransformation in the zebrafish embryo – temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene
    Environ. Pollut. 230 , 1 - 11
    Volltext (URL)
  • Välitalo, P., Massei, R., Heiskanen, I., Behnisch, P., Brack, W., Tindall, A.J., Du Pasquier, D., Küster, E., Mikola, A., Schulze, T., Sillanpää, , (2017):
    Effect-based assessment of toxicity removal during wastewater treatment
    Water Res. 126 , 153 - 163
    Volltext (URL)

2016 (3)

  • Brox, S., Seiwert, B., Haase, N., Küster, E., Reemtsma, T., (2016):
    Metabolism of clofibric acid in zebrafish embryos (Danio rerio) as determined by liquid chromatography–high resolution–mass spectrometry
    Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 185–186 , 20 - 28
    Volltext (URL)
  • Brox, S., Seiwert, B., Küster, E., Reemtsma, T., (2016):
    Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): Influence of physicochemical properties and of niological processes
    Environ. Sci. Technol. 50 (18), 10264 - 10272
    Volltext (URL)
  • Schmidt, S., Busch, W., Altenburger, R., Küster, E., (2016):
    Mixture toxicity of water contaminants-effect analysis using the zebrafish embryo assay (Danio rerio)
    Chemosphere 152 , 503 - 512
    Volltext (URL)

2015 (3)

  • Hachicho, N., Reithel, S., Miltner, A., Heipieper, H.J., Küster, E., Luckenbach, T., (2015):
    Body mass parameters, lipid profiles and protein contents of zebrafish embryos and effects of 2,4-dinitrophenol exposure
    PLOS One 10 (8), e0134755
    Volltext (URL)
  • Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R., (2015):
    What determines chemical uptake by the zebrafish embryo model?
    Toxicol. Lett. 238 (2, Suppl.), S54
    Volltext (URL)
  • Vogs, C., Kühnert, A., Hug, C., Küster, E., Altenburger, R., (2015):
    A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus
    Environ. Toxicol. Chem. 34 (1), 100 - 111
    Volltext (URL)

2014 (2)

  • Brox, S., Ritter, A.P., Küster, E., Reemtsma, T., (2014):
    A quantitative HPLC–MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos
    Anal. Bioanal. Chem. 406 (20), 4831 - 4840
    Volltext (URL)
  • Brox, S., Ritter, A.P., Küster, E., Reemtsma, T., (2014):
    Influence of the perivitelline space on the quantification of internal concentrations of chemicals in eggs of zebrafish embryos (Danio rerio)
    Aquat. Toxicol. 157 , 134 - 140
    Volltext (URL)

2013 (4)

  • Grummt, T., Kuckelkorn, J., Bahlmann, A., Baumstark-Khan, C., Brack, W., Braunbeck, T., Feles, S., Gartiser, S., Glatt, H., Heinze, R., Hellweg, C.E., Hollert, H., Junek, R., Knauer, M., Kneib-Kissinger, B., Kramer, M., Krauss, M., Küster, E., Maletz, S., Meinl, W., Noman, A., Prantl, E.-M., Rabbow, E., Redelstein, R., Rettberg, P., Schadenboeck, W., Schmidt, C., Schulze, T., Seiler, T.-B., Spitta, L., Stengel, D., Waldmann, P., Eckhardt, A., (2013):
    Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany. Tox-Box: die Tropfen des Lebens bewahren - gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland
    Environmental Sciences Europe 25 , art. 27
    Volltext (URL)
  • Kühnert, A., Vogs, C., Altenburger, R., Küster, E., (2013):
    The internal concentration of organic substances in fish embryos - a toxicokinetic approach
    Environ. Toxicol. Chem. 32 (8), 1819 - 1827
    Volltext (URL)
  • Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J., (2013):
    A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
    Regul. Toxicol. Pharmacol. 67 (3), 506 - 530
    Volltext (URL)
  • Wahyudi, A., Bartzke, M., Küster, E., Bogaert, P., (2013):
    Maximum entropy estimation of a Benzene contaminated plume using ecotoxicological assays
    Environ. Pollut. 172 , 170 - 179
    Volltext (URL)

2012 (1)

  • Gündel, U., Kalkhof, S., Zitzkat, D.P., von Bergen, M., Altenburger, R., Küster, E., (2012):
    Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome
    Ecotox. Environ. Safe. 76 (1), 11 - 22
    Volltext (URL)

2011 (1)

  • Agbo, S.O., Küster, E., Georgi, A., Akkanen, J., Leppänen, M.T., Kukkonen, J.V.K., (2011):
    Photostability and toxicity of pentachlorophenol and phenanthrene
    J. Hazard. Mater. 189 (1-2), 235 - 240
    Volltext (URL)

2010 (4)

  • Duquesne, S., Küster, E., (2010):
    Biochemical, metabolic, and behavioural responses and recovery of Daphnia magna after exposure to an organophosphate
    Ecotox. Environ. Safe. 73 (3), 353 - 359
    Volltext (URL)
  • Gündel, U., Kalkhof, S., von Bergen, M., Altenburger, R., Küster, E., (2010):
    Concentration-response concept in ecotoxicoproteomics: an optimised design for the detection of robust chemical stress associated protein markers: Effects of different concentrations of phenanthren to the proteome of Danio rerio embryos
    Comp. Biochem. Physiol. A-Mol. Integr. Physiol. 157 (Suppl. 1), S42 - S43
    Volltext (URL)
  • Hanisch, K., Küster, E., Altenburger, R., Gündel, U., (2010):
    Proteomic signatures of the zebrafish (Danio rerio) embryo: sensitivity and specificity in toxicity assessment of chemicals
    International Journal of Proteomics 2010 , Article ID 630134 - 13
    Volltext (URL)
  • Meinert, C., Schymanski, E., Küster, E., Kühne, R., Schüürmann, G., Brack, W., (2010):
    Application of preparative capillary gas chromatography (pcGC), automated structure generation and mutagenicity prediction to improve effect-directed analysis of genotoxicants in a contaminated groundwater
    Environ. Sci. Pollut. Res. 17 (4), 885 - 897
    Volltext (URL)

2009 (1)

  • Schreiber, R., Altenburger, R., Paschke, A., Schüürmann, G., Küster, E., (2009):
    A novel in vitro system for the determination of bioconcentration factors and the internal dose in zebrafish (Danio rerio) eggs
    Chemosphere 77 (7), 928 - 933
    Volltext (URL)

2008 (4)

  • Küster, E., Altenburger, R., (2008):
    Oxygen decline in biotesting of environmental samples - Is there a need for consideration in the acute zebrafish embryo assay?
    Environ.Toxicol. 23 (6), 745 - 750
    Volltext (URL)
  • Mages, M., Bandow, N., Küster, E., Brack, W., von Tümpling, W., (2008):
    Zinc and cadmium accumulation in single zebrafish (Danio rerio) embryos - A total reflection X-ray fluorescence spectrometry application
    Spectroc. Acta Pt. B-Atom. Spectr. 63 (12), 1443 - 1449
    Volltext (URL)
  • Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D., (2008):
    The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
    Environ. Sci. Pollut. Res. 15 (5), 394 - 404
    Volltext (URL)
  • Schreiber, R., Altenburger, R., Paschke, A., Küster, E., (2008):
    How to deal with lipophilic and volatile organic substances in microtiter plate assays
    Environ. Toxicol. Chem. 27 (8), 1676 - 1682
    Volltext (URL)

2007 (2)

  • Gündel, U., Benndorf, D., von Bergen, M., Altenburger, R., Küster, E., (2007):
    Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach
    Proteomics 7 (24), 4541 - 4554
    Volltext (URL)
  • Küster, E., Altenburger, R., (2007):
    Suborganismic and organismic effects of aldicarb and its metabolite aldicarb-sulfoxide to the zebrafish embryo (Danio rerio)
    Chemosphere 68 (4), 751 - 760
    Volltext (URL)

2006 (2)

  • Altenburger, R., Brack, W., Greco, W.R., Grote, M., Jung, K., Ovari, A., Riedl, J., Schwab, K., Küster, E., (2006):
    On the mode of action of N-phenyl-2-naphthylamine in plants
    Environ. Sci. Technol. 40 (19), 6163 - 6169
    Volltext (URL)
  • Küster, E., Altenburger, R., (2006):
    Comparison of cholin- and carboxylesterase enzyme inhibition and visible effects in the zebra fish embryo bioassay under short-term paraoxon-methyl exposure
    Biomarkers 11 (4), 341 - 354
    Volltext (URL)

2005 (5)

  • Kaschl, A., Schultz, A., Vogt, C., Dorusch, F., Popp, P., Borsdorf, H., Küster, E., Kuschk, P., Kästner, M., Weiß, H., (2005):
    A meso-scale constructed wetland for the remediation of chlorobenzene contaminated groundwater
    In: Thomson, N.R., (ed.)
    Bringing groundwater quality research to the watershed scale (GQ2004 International conference of groundwater quality: bringing groundwater quality research to the watershed scale, Waterloo, Canada, 19.-22.7.2004)
    IAHS Publ. 297
    International Association of Hydrological Sciences (IAHS), Wallingford, Oxfordshire, p. 404 - 411
  • Küster, E., (2005):
    Cholin- and carboxylesterase activities in developing zebrafish embryos (Danio rerio) and their potential use for insecticide hazard assessment
    Aquat. Toxicol. 75 (1), 76 - 85
    Volltext (URL)
  • Küster, E., Dorusch, F., Altenburger, R., (2005):
    Toxizität von Schwefelwasserstoff (H2S) auf die Biotestorganismen Vibrio fischeri und Daphnia magna
    Tagungsbericht 2004 der Deutschen Gesellschaft für Limnologie e.V. (DGL) und der Deutschsprachigen Sektion der Societas Internationalis Limnologiae (SIL). Potsdam, 20. - 24.09.2004
    Deutsche Gesellschaft für Limnologie, Berlin, S. 561 - 565
  • Küster, E., Dorusch, F., Altenburger, R., (2005):
    Effects of hydrogen sulfide to Vibrio fischeri, Scenedesmus vacuolatus, and Daphnia magna
    Environ. Toxicol. Chem. 24 (10), 2621 - 2629
    Volltext (URL)
  • Olajire, A.A., Altenburger, R., Küster, E., Brack, W., (2005):
    Chemical and ecotoxicological assessment of polycyclic aromatic hydrocarbon-contaminated sediments of the Niger Delta, Southern Nigeria
    Sci. Total Environ. 340 (1-3), 123 - 136
    Volltext (URL)

2004 (2)

  • Küster, E., Dorusch, F., Altenburger, R., (2004):
    Ökotoxikologische Verfahren der Wirkungsanalyse für das Management von Grundwasser-Kontaminationen: Fallbeispiel quartärer Grundwasserleiter in Bitterfeld-Süd
    In: Weiß, H., Teutsch, G., Daus, B., (Hrsg.)
    SAFIRA (Sanierungsforschung in regional kontaminierten Aquiferen)
    UFZ-Bericht 13/2004
    UFZ Leipzig-Halle GmbH, Leipzig, S. 287 - 316
    Volltext (PDF)
  • Küster, E., Dorusch, F., Vogt, C., Weiß, H., Altenburger, R., (2004):
    On line biomonitors used as a tool for toxicity reduction evaluation of in situ groundwater remediation techniques
    Biosens. Bioelectron. 19 (12), 1711 - 1722
    Volltext (URL)

2003 (4)

  • Brack, W., Altenburger, R., Küster, E., Meissner, B., Wenzel, K.-D., Schüürmann, G., (2003):
    Identification of toxic products of anthracene photomodification in simulated sunlight
    Environ. Toxicol. Chem. 22 (10), 2228 - 2237
    Volltext (URL)
  • Küster, E., Dorusch, F., Meißner, B., Weiß, H., Schüürmann, G., Altenburger, R., (2003):
    Toxizitätsreduktion durch (Grundwasser-) Sanierung?
    Grundwasser 8 (1), 32 - 40
    Volltext (URL)
  • Küster, E., Dorusch, F., Weiß, H., Altenburger, R., (2003):
    Controlling (groundwater-) remediation success via on line biomonitoring or how toxic is remediated groundwater?
    ConSoil 2003 : proceedings of the 8th International FZK/TNO Conference on Contaminated Soil, ICC Gent, Belgium, 12 - 16 May 2003
    F&U confirm, Leipzig, p. 3305 - 3314
  • Küster, E., Dorusch, F., Weiß, H., Schüürmann, G., Altenburger, R., (2003):
    Beurteilung der Entgiftung von Grundwasser durch Sanierungsverfahren mittels kontinuierlicher biologischer Überwachung
    In: Foth, H., (Hrsg.)
    Risk assessment and management of large contamination sites. Gefahrenabschätzung und Handhabung großflächiger Kontaminationen. Proceedingsband zum Kongress an der Martin-Luther-Universität Halle-Wittenberg, 22. - 24. Februar 2002
    S. 41 - 45

2001 (1)

  • Küster, E., Dorusch, F., Weiß, H., Altenburger, R., (2001):
    TRE-Toxicity-Reduction-Evaluation - Approaches for continuous effect monitoring of in situ groundwater remediation techniques
    11th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC) Europe, Madrid, Spain, 6-10 May 2001
    SETAC Europe, Brussels,

2000 (1)

  • Mühlbauer, B., Küster, E., Luippold, G., (2000):
    Dopamine D3 receptors in the rat kidney: Role in physiology and pathophysiology
    Acta Physiol.Scand. 168 (1), 219 - 223
    Volltext (URL)