Dr. Eberhard Küster
Eberhard Küster was trained as a Biological-Technical Assistant at the „Regional Office for Fishery in North Rhine -Westphalia“ i.e. Landesanstalt für Fischerei, Nordrhein-Westfalen Germany from 1987 to 1989. He got his diploma in biology after studying Biology and Marine Biology at the University of Marburg, Germany, the Juniata College (Pennsylvania, USA), the Duke University Marine Laboratory, Beaufort (NC, USA) and the University of Rostock, Germany (Supervisor Karl Jürß) from '89 to '96. He received his PhD (Dr. rer. nat.) from the University of Tübingen, Germany in the Department of Pharmacology and Toxicology in the year 2000 (Supervisor Bernd Mühlbauer). From 2000 to 2010 he held several PostDoc positions in the Departments Chemical Ecotoxicology and Bioanalytical Ecotoxicology at the Helmholtz Centre for Environmental Research – UFZ in the research areas of groundwater remediation evaluation, biomarker development and hazard assessment with different bioassays. Since 2010 he works as a research associate at the Dept. Bioanalytical Ecotoxicology of the UFZ and is the head of the work group „Stress Physiology“. In 2013 E. Küster received a fellowship award by the OECD Co-operative Research Programme: Biological Resource Management for Sustainable Agricultural Systems in 2013 for research at the NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA (Marie DeLorenzo and Mike Fulton lab). Currently he also holds a teaching assignment at the Technical University Bergakademie Freiberg.
The research interests broadly include two topics which are ancillary to the general goal of further upgrading of zebrafish embryos (Danio rerio) as an alternative for animal testing (DarT) for risk assessment of substances with specific and unspecific mode of action (lipophilic/ volatile substances, pharmaceuticals, genotoxins). First, the determination of the internal dose over time as a measure for the effective concentration is in focus to better understand physiologically-based toxicokinetics (PBTK). Secondly, the effects of single substances and mixtures thereof on fish embryos are observed on different sublethal levels with a major focus on the analysis of the proteome (Ecotoxicoproteomics) as a tool to identify important sublethal stress effects and primary and higher level reactions (close cooperation with the Dept. Proteomics at the UFZ). Chemical analysis of the internal concentrations is mainly done with LC and GC methods and also in close cooperation with the Analytics Department of the UFZ (T. Reemtsma).
Recent third party funded project: NeuroBox includes the effect directed identification & the single and mixture analysis of neuroactive drinking water contaminants with the acute Danio rerio fish embryo assay on different effect levels.