Dr. Dana Kühnel

Dr. Dana Kühnel
Foto: Sebastian Wiedling/UFZ

Adresse:
Permoserstr. 15
04318 Leipzig

Gebäude: 6.0
Raum: 230
Telefon: +49 341 235 1515

Dr. Dana Kühnel 

Curriculum Vitae 

Dana Kühnel received her doctorate in the Department of Nutritional Toxicology of the University of Potsdam. Her doctoral thesis dealt with the development of colon cancer induced by polycyclic aromatic amines, formed during the heating of meat products. After finishing her PhD, in 2006 she joined the Department Cell Toxicology as a postdoctoral researcher (since 2009 the Department of Bioanalytical Ecotoxicology).

The focus of her research shifted to the assessment of potential (eco)toxicological effects of engineered nanomaterials. In several third-party funded projects (e.g. BMBF, EU-FP7, UBA), Dana tackled since then how technically produced nanomaterials affect the health of organisms, how they are internalized and distributed within organisms and how novel findings on nanomaterial-organism-interaction cans be communicated to outside the scientific world.
Specifically, the research activities focus on elucidating the influence of nanomaterial properties on the toxic outcome, the optimization and adaptation of test systems and protocols used in the risk assessment of chemicals for nanomaterials, and the development of analytical methods to gain qualitative and quantitative information on nanomaterial-organisms-interactions in a time- and space resolved manner. In addition, mixture effects between nanomaterials and chemicals are assessed. The outcomes of these activities feed into the development of risk assessment and grouping strategies for engineered nanomaterials.

Since 2009, Dana Kühnel also has been engaged in science communication by evaluating and summarizing scientific results dealing with the environmental impact of nanomaterials to a broad audience. This information is transported via the knowledgebase website www.nanoobjects.info. Starting in 2014, the research field on potential adverse of particles towards environmental organisms was expanded by including microplastic particles and aerosol particles into the research activities.

Aktuelle Projekte

DaNa2.0 - Data and knowledge on Nanomaterials - Processing of socially relevant scientific facts

NanoValid - Development of reference methods for hazard identification, risk assessment and LCA of engineered nanomaterials

nanoGRAVUR – Nanostrukturierte Materialien – Gruppierung hinsichtlich Arbeits-, Verbraucher- und Umweltschutz und Risikominimierung

GruppNano – Gruppierung von Nanomaterialien im Hinblick auf eine gemeinsame Prüfung von Umweltwirkung für Regulierungsaspekte (UBA-UFO Plan Projekt)

WeatherMICS (JPI Oceans) - How weathering processes influence the transport, fate and toxicity of microplastics (MPs) and their leachates in the marine environment

Abgeschlossene Projekte

FeNanosit - Iron-based nanoparticles and nanocomposite structures for removal of contaminants from groundwater and wastewater

DaNa - acquisition, evaluation and public-oriented presentation of society-relevant data and findings relating to nanomaterials

Rapporting to the International expert meeting „OECD Horizontal Meeting on Eco-Toxicology and Environmental Fate of Nanomaterials“, OECD-WPMN / BMU / UBA

INOS - Identifizierung und Bewertung von Gesundheits- und Umweltauswirkungen von technischen nanoskaligen Partikeln; BMBF-Projekt; Arbeitspaket 4 / UFZ-Toxikologische Analyse von Nanopartikeln und Identifizierung von Wirkungsmechanismen

Publikationen

2017 (7)

  • Böhme, S., Baccaro, M., Schmidt, M., Potthoff, A., Stärk, H.-J., Reemtsma, T., Kühnel, D., (2017):
    Metal uptake and distribution in the zebrafish (Danio rerio) embryo: differences between nanoparticles and metal ions
    Environ. Sci.: Nano 4 (5), 1005 - 1015
    Volltext (URL)
  • Kühnel, D., Marquardt, C., Nau, K., Krug, H.F., Paul, F., Steinbach, C., (2017):
    Environmental benefits and concerns on safety: communicating latest results on nanotechnology safety research—the project DaNa2.0
    Environ. Sci. Pollut. Res. 24 (12), 11120 - 11125
    Volltext (URL)
  • Potthoff, A., Oelschlägel, K., Schmitt-Jansen, M., Rummel, C.D., Kühnel, D., (2017):
    From the sea to the laboratory: Characterization of microplastic as prerequisite for the assessment of ecotoxicological impact
    Integr. Environ. Assess. Manag. 13 (3), 500 - 504
    Volltext (URL)
  • Ribeiro, A.R., Leite, P.E., Falagan-Lotsch, P., Benetti, F., Micheletti, C., Budtz, H.C., Jacobsen, N.R., Lisboa-Filho, P.N., Rocha, R.A., Kühnel, D., Hristozov, D., Granjeiro, J.M., (2017):
    Challenges on the toxicological predictions of engineered nanoparticles
    NanoImpact 8 , 59 - 72
    Volltext (URL)
  • Rummel, C.D., Jahnke, A., Gorokhova, E., Kühnel, D., Schmitt-Jansen, M., (2017):
    Impacts of biofilm formation on the fate and potential effects of microplastic in the aquatic environment
    Environ. Sci. Technol. Lett. 4 (7), 258 - 267
    Volltext (URL)
  • Schmidt, S., Altenburger, R., Kühnel, D., (2017):
    From the air to the water phase: implication for toxicity testing of combustion-derived particles
    Biomass Conversion and Biorefinery
    Volltext (URL)
  • Steinbach, C., Bohmer, N., Krug, H.F., Kühnel, D., Nau, K., Paul, F., Reithel, S., Marquardt, C., (2017):
    DaNa 2.0 – verlässliche Informationen zur Sicherheit von marktüblichen Nanomaterialien. DaNa 2.0 – reliable information on the safety of commercially available nanomaterials
    Chem. Ing. Tech. 89 (3), 232 - 238
    Volltext (URL)

2016 (4)

  • Heinlaan, M., Muna, M., Knöbel, M., Kistler, D., Odzak, N., Kühnel, D., Müller, J., Gupta, G.S., Kumar, A., Shanker, R., Sigg, L., (2016):
    Natural water as the test medium for Ag and CuO nanoparticle hazard evaluation: An interlaboratory case study
    Environ. Pollut. 216 , 689 - 699
    Volltext (URL)
  • Jemec, A., Kahru, A., Potthoff, A., Drobne, D., Heinlaan, M., Böhme, S., Geppert, M., Novak, S., Schirmer, K., Rekulapally, R., Singh, S., Aruoja, V., Sihtmäe, M., Juganson, K., Käkinen, A., Kühnel, D., (2016):
    An interlaboratory comparison of nanosilver characterisation and hazard identification: Harmonising techniques for high quality data
    Environ. Int. 87 , 20 - 32
    Volltext (URL)
  • Kos, M., Kahru, A., Drobne, D., Singh, S., Kalčíková, G., Kühnel, D., Rohit, R., Gotvajn, A.Z., Jemec, A., (2016):
    A case study to optimise and validate the brine shrimp Artemia franciscana immobilisation assay with silver nanoparticles: The role of harmonisation
    Environ. Pollut. 213 , 173 - 183
    Volltext (URL)
  • Nau, K., Bohmer, N., Kühnel, D., Marquardt, C., Paul, F., Steinbach, C., Krug, H.F., (2016):
    The DaNa2.0 knowledge base on nanomaterials – Communicating current nanosafety research based on evaluated literature data
    J. Mat. Educ. 38 (3-4), 93 - 108

2015 (5)

  • Böhme, S., Kühnel, D., Stärk, H.-J., Reemtsma, T., (2015):
    New developments in the field of the visualization of nanoparticle uptake by environmental organisms with LA-ICP-MS
    In: Daus, B., Bings, N., Leopold, K., Otto, M., Panne, U., Welz, U., Wennrich, R., (eds.)
    Canas ’15. Colloquium Analytische Atomspektroskopie, 8.–11. März 2015, Helmholtz-Zentrum für Umweltforschung – UFZ Leipzig. Colloquium Analytical Atomic Spectroscopy, 8–11 March, 2015, Helmholtz Centre for Environmental Research – UFZ Leipzig
    Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, p. 61 - 62
  • Böhme, S., Stärk, H.-J., Kühnel, D., Reemtsma, T., (2015):
    Exploring LA-ICP-MS as a quantitative imaging technique to study nanoparticle uptake in Daphnia magna and zebrafish (Danio rerio) embryos
    Anal. Bioanal. Chem. 407 (18), 5477 - 5485
    Volltext (URL)
  • Böhme, S., Stärk, H.-J., Reemtsma, T., Kühnel, D., (2015):
    Effect propagation after silver nanoparticle exposure in zebrafish (Danio rerio) embryos: a correlation to internal concentration and distribution patterns
    Environ. Sci.: Nano 2 (6), 603 - 614
    Volltext (URL)
  • Potthoff, A., Weil, M., Meißner, T., Kühnel, D., (2015):
    Towards sensible toxicity testing for nanomaterials: proposal for the specification of test design
    Sci. Technol. Adv. Mater. 16 (6), art. 065006
    Volltext (URL)
  • Weil, M., Meißner, T., Busch, W., Springer, A., Kühnel, D., Schulz, R., Duis, K., (2015):
    The oxidized state of the nanocomposite Carbo-Iron® causes no adverse effects on growth, survival and differential gene expression in zebrafish
    Sci. Total Environ. 530-531 , 198 - 208
    Volltext (URL)

2014 (6)

  • Böhme, S., Stärk, H.-J., Meißner, T., Springer, A., Reemtsma, T., Kühnel, D., Busch, W., (2014):
    Quantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods
    J. Nanopart. Res. 16 , 2592
    Volltext (URL)
  • Krug, H.F., Wick, P., Hirsch, C., Kühnel, D., Marquardt, C., Nau, K., Mathes, B., Steinbach, C., (2014):
    Im Gleichgewicht? Risikoforschung zu Nanomaterialien : die internationale Risikodebatte zur Nanotechnologie und zu möglichen Vorsorgemaßnahmen für Arbeitsplatz und Verbraucher
    Arbeitsmedizin, Sozialmedizin, Umweltmedizin : ASU 43 (1), 6 - 18
  • Kühnel, D., Marquardt, C., Nau, K., Krug, H.F., Mathes, B., Steinbach, C., (2014):
    Environmental impacts of nanomaterials: providing comprehensive information on exposure, transport and ecotoxicity - the project DaNa2.0
    Environmental Sciences Europe 26 , art. 21
    Volltext (URL)
  • Kühnel, D., Nickel, C., (2014):
    The OECD expert meeting on ecotoxicology and environmental fate — towards the development of improved OECD guidelines for the testing of nanomaterials
    Sci. Total Environ. 472 , 347 - 353
    Volltext (URL)
  • Kühnel, D., Nickel, C., (eds., 2014):
    Ecotoxicology and environmental fate of manufactured nanomaterials: test guidelines
    Series on the Safety of Manufactured Nanomaterials 40 - ENV/JM/MONO(2014)1
    OECD Organisation for Economic Co-operation and Development, Paris, 84 pp.
    Volltext (URL)
  • Oomen, A.G., Bos, P.M.J., Fernandes, T.F., Hund-Rinke, K., Boraschi, D., Byrne, H.J., Aschberger, K., Gottardo, S., von der Kammer, F., Kühnel, D., Hristozov, D., Marcomini, A., Migliore, L., Scott-Fordsmand, J., Wick, P., Landsiedel, R., (2014):
    Concern-driven integrated approaches to nanomaterial testing and assessment – report of the NanoSafety Cluster Working Group 10
    Nanotoxicology 8 (3), 334 - 348
    Volltext (URL)

2013 (3)

  • Jackson, P., Jacobsen, N.R., Baun, A., Birkedal, R., Kühnel, D., Jensen, K.A., Vogel, U., Wallin, H., (2013):
    Bioaccumulation and ecotoxicity of carbon nanotubes
    Chem. Cent. J. 7 , 154
    Volltext (URL)
  • Kroll, A., Kühnel, D., Schirmer, K., (2013):
    Testing nanomaterial toxicity in unicellular eukaryotic algae and fish cell lines
    In: Armstrong, D., Bharali, D.J., (eds.)
    Oxidative stress and nanotechnology: methods and protocols
    Methods in Molecular Biology 1028
    Humana Press, Totowa, NJ, p. 165 - 195
    Volltext (URL)
  • Marquardt, C., Kühnel, D., Richter, V., Krug, H.F., Mathes, B., Steinbach, C., Nau, K., (2013):
    Latest research results on the effects of nanomaterials on humans and the environment: DaNa - Knowledge Base Nanomaterials
    J. Phys.: Conf. Ser. 429 , 012060
    Volltext (URL)

2012 (2)

  • Kühnel, D., Scheffler, K., Wellner, P., Meißner, T., Potthoff, A., Busch, W., Springer, A., Schirmer, K., (2012):
    Comparative evaluation of particle properties, formation of reactive oxygen species and genotoxic potential of tungsten carbide based nanoparticles in vitro
    J. Hazard. Mater. 227-228 , 418 - 426
    Volltext (URL)
  • Steinbach, C., Mathes, B., Krug, H.F., Wiek, P., Kühnel, D., (2012):
    Die Sicherheit von Nanomaterialien in der Diskussion
    Deutsche Apotheker-Zeitung 152 (16), 90 - 92

2011 (1)

  • Busch, W., Bastian, S., Trahorsch, U., Iwe, M., Kühnel, D., Meißner, T., Springer, A., Gelinsky, M., Richter, V., Ikonomidou, C., Potthoff, A., Lehmann, I., Schirmer, K., (2011):
    Internalisation of engineered nanoparticles into mammalian cells in vitro: influence of cell type and particle properties
    J. Nanopart. Res. 13 (1), 293 - 310
    Volltext (URL)

2010 (5)

  • Altenburger, R., Berns, A.E., Bittens, M., Brack, W., Burauel, P., Centler, F., Daus, B., Goss, K.-U., Harms, H., Kopinke, F.-D., Kühnel, D., Liess, M., Mackenzie, K., Miltner, A., Thullner, M., Wennrich, R., Wick, L.Y., (2010):
    Chemicals in the environment (CITE). Report of the First Annual Conference of the Helmholtz research topic CITE
    UWSF 22 (4), 502 - 506
    Volltext (URL)
  • Busch, W., Kühnel, D., Schirmer, K., Scholz, S., (2010):
    Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    BMC Genomics 11 , art. 65
    Volltext (URL)
  • Hildebrand, H., Kühnel, D., Potthoff, A., Mackenzie, K., Springer, A., Schirmer, K., (2010):
    Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment
    Environ. Pollut. 158 (1), 65 - 73
    Volltext (URL)
  • Meissner, T., Kühnel, D., Busch, W., Oswald, S., Richter, V., Michaelis, A., Schirmer, K., Potthoff, A., (2010):
    Physical-chemical characterization of tungsten carbide nanoparticles as a basis for toxicological investigations
    Nanotoxicology 4 (2), 196 - 206
    Volltext (URL)
  • Stärk, H.-J., Kühnel, D., Busch, W., Wellner, P., Schirmer, C., (2010):
    Charakterisierung der Aufnahme von Wolframkarbid-Nanopartikeln durch Humanzellen mittels LA-ICP-MS
    In: Otto, M., Bulska, E., Knapp, G., Schlemmer, G., Ullrich, A., Welz, B., Wennrich, R., (Hrsg.)
    CANAS '09 - Colloquium Analytische Atomspektroskopie, 22.-25. März 2009, Freiberg
    TU Bergakademie Freiberg, Institut für Analytische Chemie, Freiberg, S. 44 - 44

2009 (5)

  • Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K., (2009):
    Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
    Environ. Health Perspect. 117 (4), 530 - 536
    Volltext (URL)
  • Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K., (2009):
    Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
    Toxicol. Lett. 189 (Suppl. 1), S185 - S185
    Volltext (URL)
  • Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K., (2009):
    Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
    Aquat. Toxicol. 93 (2-3), 91 - 99
    Volltext (URL)
  • Kühnel, D., Taugner, F., Scholtka, B., Steinberg, P., (2009):
    Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats
    Arch. Toxicol. 83 (8), 763 - 768
    Volltext (URL)
  • Potthoff, A., Meißner, T., Richter, V., Busch, W., Kühnel, D., Bastian, S., Iwe, M., Springer, A., (2009):
    Evaluation of health risks of nanoparticles - a contribution to a sustainable development of nanotechnology
    In: Kny, E., (ed.)
    Nanocomposite materials
    Solid State Phenomena 151
    Trans Tech Publications, Durnten-Zurich, p. 183 - 189
    Volltext (URL)

2004 (2)

  • Baumann, O., Kühnel, D., Dames, P., Walz, B., (2004):
    Dopaminergic and serotonergic innervation of cockroach salivary glands: distribution and morphology of synapses and release sites
    J. Exp. Biol. 207 (15), 2565 - 2575
    Volltext (URL)
  • Kühnel, D., Steinberg, P., Scholtka, B., (2004):
    A human-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) can induce precancerous lesions in rat intestine after 6 months of exposure
    Naunyn-Schmiedebergs Arch. Pharmacol. 369 (Suppl. 1), R143
    Volltext (URL)