Dr. Wibke Busch
Wibke Busch studied Process Engineering and Biotechnology in Dresden and Jena (Germany) and received the Diploma for her work on the “Structural and functional evolution of the V2-vasopressin receptor”. This project was performed at the Institute of Biochemistry at the Medical Faculty of the University of Leipzig. During her PhD studies at the UFZ Department of Cell Toxicology she investigated the toxic mechanisms of metalloid nanoparticles and organic chemicals in cell culture systems and established herself in the field of toxicogenomics including bioinformatics and pathway analyses. For her PhD work she received a best presentation award at the UFZ as well as the SETAC GLB best PhD thesis award in 2011. Since 2011 Wibke Busch holds third party funded postdoctoral research positions in the Department Bioanalytical Ecotoxicology where she established her own working group. In 2016 she recieved the Cefic-LRI innovative science award.
Her profile in molecular toxicology is based on experiences in molecular biology including gene expression, cloning, and enzyme activity studies in cell cultures; chemical exposures including nanoparticles, organic chemicals, and metals; toxicogenomics including targeted and untargeted gene expression in human cell lines and zebrafish embryos (Danio rerio) as well as microarray design and performance; and in the analyses of big datasets and data bases applying multivariate statistics, concentration response modelling, gene set and pathway analysis, and hazard assessment.
Her current research is focused on the mode of action based hazard assessment and the determination of time and concentration dependent molecular toxicity pathways of environmental chemicals and their mixtures. Therefore she investigates and analyses chemicals measured in European rivers respecting their toxicogenomic profiles, molecular mixture effects, and hazard potentials (via hazard quotient determination). Furthermore, she is interested in modelling approaches (respecting effect translation and network dynamics) and therefore cooperating with bioinformaticians and systems biologists. The results of her work enlarge the mechanistic understanding of molecular toxicity pathways in the context of toxicokinetic and toxicodynamic action, guide toxicogenomics experiments in ecotoxicology and will provide ideas and approaches for an effect based risk assessment.