Dr. Wibke Busch

Dr. Wibke Busch
Foto: Josefine Müller

Adresse:
Permoserstr. 15
04318 Leipzig

Gebäude: 6.0
Raum: 230
Telefon: +49 341 235 1515

Dr. Wibke Busch

Curriculum Vitae

Wibke Busch studied Process Engineering and Biotechnology in Dresden and Jena (Germany) and received the Diploma for her work on the “Structural and functional evolution of the V2-vasopressin receptor”. This project was performed at the Institute of Biochemistry at the Medical Faculty of the University of Leipzig. During her PhD studies at the UFZ Department of Cell Toxicology she investigated the toxic mechanisms of metalloid nanoparticles and organic chemicals in cell culture systems and established herself in the field of toxicogenomics including bioinformatics and pathway analyses. For her PhD work she received a best presentation award at the UFZ as well as the SETAC GLB best PhD thesis award in 2011. Since 2011 Wibke Busch holds third party funded postdoctoral research positions in the Department Bioanalytical Ecotoxicology where she established her own working group. In 2016 she recieved the Cefic-LRI innovative science award.

Her profile in molecular toxicology is based on experiences in molecular biology including gene expression, cloning, and enzyme activity studies in cell cultures; chemical exposures including nanoparticles, organic chemicals, and metals; toxicogenomics including targeted and untargeted gene expression in human cell lines and zebrafish embryos (Danio rerio) as well as microarray design and performance; and in the analyses of big datasets and data bases applying multivariate statistics, concentration response modelling, gene set and pathway analysis, and hazard assessment.

Her current research is focused on the mode of action based hazard assessment and the determination of time and concentration dependent molecular toxicity pathways of environmental chemicals and their mixtures. Therefore she investigates and analyses chemicals measured in European rivers respecting their toxicogenomic profiles, molecular mixture effects, and hazard potentials (via hazard quotient determination). Furthermore, she is interested in modelling approaches (respecting effect translation and network dynamics) and therefore cooperating with bioinformaticians and systems biologists. The results of her work enlarge the mechanistic understanding of molecular toxicity pathways in the context of toxicokinetic and toxicodynamic action, guide toxicogenomics experiments in ecotoxicology and will provide ideas and approaches for an effect based risk assessment.

Publikationen

2017 (5)

  • Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F., (2017):
    From the exposome to mechanistic understanding of chemical-induced adverse effects
    Environ. Int. 99 , 97 - 106
    Volltext (URL)
  • Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W., (2017):
    Biotransformation in the zebrafish embryo – temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene
    Environ. Pollut. 230 , 1 - 11
    Volltext (URL)
  • Neale, P.A., Altenburger, R., Aït-Aïssa, S., Brion, F., Busch, W., De Aragão Umbuzeiro, G., Denison, M.S., Du Pasquier, D., Hilscherová, K., Hollert, H., Morales, D.A., Novák, J., Schlichting, R., Seiler, T.-B., Serra, H., Shao, Y., Tindall, A.J., Tollefsen, K.E., Williams, T.D., Escher, B.I., (2017):
    Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water
    Water Res. 123 , 734 - 750
    Volltext (URL)
  • Neale, P.A., Munz, N.A., Aїt-Aїssa, S., Altenburger, R., Brion, F., Busch, W., Escher, B.I., Hilscherová, K., Kienle, C., Novák, J., Seiler, T.-B., Shao, Y., Stamm, C., Hollender, J., (2017):
    Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams
    Sci. Total Environ. 576 , 785 - 795
    Volltext (URL)
  • Schüttler, A., Reiche, K., Altenburger, R., Busch, W., (2017):
    The transcriptome of the zebrafish embryo after chemical exposure: a meta-analysis
    Toxicol. Sci. 157 (2), 291 - 304
    Volltext (URL)

2016 (3)

  • Brack, W., Ait-Aissa, S., Burgess, R.M., Busch, W., Creusot, N., Di Paolo, C., Escher, B.I., Hewitt, L.M., Hilscherova, K., Hollender, J., Hollert, H., Jonker, W., Kool, J., Lamoree, M., Muschket, M., Neumann, S., Rostkowski, P., Ruttkies, C., Schollee, J., Schymanski, E.L., Schulze, T., Seiler, T.-B., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Krauss, M., (2016):
    Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview
    Sci. Total Environ. 544 , 1073 - 1118
    Volltext (URL)
  • Busch, W., Schmidt, S., Kühne, R., Schulze, T., Krauss, M., Altenburger, R., (2016):
    Micropollutants in European rivers: A mode of action survey to support the development of effect-based tools for water monitoring
    Environ. Toxicol. Chem. 35 (8), 1887 - 1899
    Volltext (URL)
  • Schmidt, S., Busch, W., Altenburger, R., Küster, E., (2016):
    Mixture toxicity of water contaminants-effect analysis using the zebrafish embryo assay (Danio rerio)
    Chemosphere 152 , 503 - 512
    Volltext (URL)

2015 (4)

  • Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barceló, D., Seiler, T.-B., Brion, F., Busch, W., Chipman, K., López de Alda, M., De Aragão Umbuzeiro, G., Escher, B.I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jäger, F., Jahnke, A., Kortenkamp, A., Krauss, M., Lemkine, G.F., Munthe, J., Neumann, S., Schymanski, E.L., Scrimshaw, M., Segner, H., Slobodnik, J., Smedes, F., Kughathas, S., Teodorovic, I., Tindall, A.J., Tollefsen, K.E., Walz, K.-H., Williams, T.D., van den Brink, P.J., van Gils, J., Vrana, B., Zhang, X., Brack, W., (2015):
    Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management
    Sci. Total Environ. 512-513 , 540 - 551
    Volltext (URL)
  • Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R., (2015):
    What determines chemical uptake by the zebrafish embryo model?
    Toxicol. Lett. 238 (2, Suppl.), S54
    Volltext (URL)
  • Smetanová, S., Riedl, J., Zitzkat, D.P., Altenburger, R., Busch, W., (2015):
    High-throughput concentration–response analysis for omics datasets
    Environ. Toxicol. Chem. 34 (9), 2167 - 2180
    Volltext (URL)
  • Weil, M., Meißner, T., Busch, W., Springer, A., Kühnel, D., Schulz, R., Duis, K., (2015):
    The oxidized state of the nanocomposite Carbo-Iron® causes no adverse effects on growth, survival and differential gene expression in zebrafish
    Sci. Total Environ. 530-531 , 198 - 208
    Volltext (URL)

2014 (2)

  • Böhme, S., Stärk, H.-J., Meißner, T., Springer, A., Reemtsma, T., Kühnel, D., Busch, W., (2014):
    Quantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods
    J. Nanopart. Res. 16 , 2592
    Volltext (URL)
  • Escher, B.I., Allinson, M., Altenburger, R., Bain, P.A., Balaguer, P., Busch, W., Crago, J., Denslow, N.D., Dopp, E., Hilscherova, K., Humpage, A.R., Kumar, A., Grimaldi, M., Jayasinghe, B.S., Jarosova, B., Jia, A., Makarov, S., Maruya, K.A., Medvedev, A., Mehinto, A.C., Mendez, J.E., Poulsen, A., Prochazka, E., Richard, J., Schifferli, A., Schlenk, D., Scholz, S., Shiraishi, F., Snyder, S., Su, G., Tang, J.Y.M., van der Burg, B., van der Linden, S.C., Werner, I., Westerheide, S.D., Wong, C.K.C., Yang, M., Yeung, B.H.Y., Zhang, X., Leusch, F.D.L., (2014):
    Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
    Environ. Sci. Technol. 48 (3), 1940 - 1956
    Volltext (URL)

2012 (3)

  • Altenburger, R., Scholz, S., Schmitt-Jansen, M., Busch, W., Escher, B.I., (2012):
    Mixture toxicity revisited from a toxicogenomic perspective
    Environ. Sci. Technol. 46 (5), 2508 - 2522
    Volltext (URL)
  • Büttner, A., Busch, W., Klüver, N., Giannis, A., Scholz, S., (2012):
    Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
    Reprod. Toxicol. 33 (2), 254 - 263
    Volltext (URL)
  • Kühnel, D., Scheffler, K., Wellner, P., Meißner, T., Potthoff, A., Busch, W., Springer, A., Schirmer, K., (2012):
    Comparative evaluation of particle properties, formation of reactive oxygen species and genotoxic potential of tungsten carbide based nanoparticles in vitro
    J. Hazard. Mater. 227-228 , 418 - 426
    Volltext (URL)

2011 (3)

  • Busch, W., Bastian, S., Trahorsch, U., Iwe, M., Kühnel, D., Meißner, T., Springer, A., Gelinsky, M., Richter, V., Ikonomidou, C., Potthoff, A., Lehmann, I., Schirmer, K., (2011):
    Internalisation of engineered nanoparticles into mammalian cells in vitro: influence of cell type and particle properties
    J. Nanopart. Res. 13 (1), 293 - 310
    Volltext (URL)
  • Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., Scholz, S., (2011):
    The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany
    Reprod. Toxicol. 31 (4), 585 - 588
    Volltext (URL)
  • Klüver, N., Yang, L., Busch, W., Scheffler, K., Scheffler, P., Strähle, U., Scholz, S., (2011):
    Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
    PLoS One 6 (12), e29063
    Volltext (URL)

2010 (4)

  • Busch, W., (2010):
    Toxicity of engineered nanoparticles towards vertebrate cells in vitro
    Dissertation, Martin-Luther-Universität Halle-Wittenberg
    PhD Dissertation 15/2010
    Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, 150 pp.
    Volltext (PDF)
  • Busch, W., Kühnel, D., Schirmer, K., Scholz, S., (2010):
    Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    BMC Genomics 11 , art. 65
    Volltext (URL)
  • Meissner, T., Kühnel, D., Busch, W., Oswald, S., Richter, V., Michaelis, A., Schirmer, K., Potthoff, A., (2010):
    Physical-chemical characterization of tungsten carbide nanoparticles as a basis for toxicological investigations
    Nanotoxicology 4 (2), 196 - 206
    Volltext (URL)
  • Stärk, H.-J., Kühnel, D., Busch, W., Wellner, P., Schirmer, C., (2010):
    Charakterisierung der Aufnahme von Wolframkarbid-Nanopartikeln durch Humanzellen mittels LA-ICP-MS
    In: Otto, M., Bulska, E., Knapp, G., Schlemmer, G., Ullrich, A., Welz, B., Wennrich, R., (Hrsg.)
    CANAS '09 - Colloquium Analytische Atomspektroskopie, 22.-25. März 2009, Freiberg
    TU Bergakademie Freiberg, Institut für Analytische Chemie, Freiberg, S. 44 - 44

2009 (5)

  • Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K., (2009):
    Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
    Environ. Health Perspect. 117 (4), 530 - 536
    Volltext (URL)
  • Böselt, I., Römpler, H., Hermsdorf, T., Thor, D., Busch, W., Schulz, A., Schöneberg, T., (2009):
    Involvement of the V2 vasopressin receptor in adaptation to limited water supply
    PLoS One 4 (5), e5573
    Volltext (URL)
  • Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K., (2009):
    Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
    Toxicol. Lett. 189 (Suppl. 1), S185 - S185
    Volltext (URL)
  • Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K., (2009):
    Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
    Aquat. Toxicol. 93 (2-3), 91 - 99
    Volltext (URL)
  • Potthoff, A., Meißner, T., Richter, V., Busch, W., Kühnel, D., Bastian, S., Iwe, M., Springer, A., (2009):
    Evaluation of health risks of nanoparticles - a contribution to a sustainable development of nanotechnology
    In: Kny, E., (ed.)
    Nanocomposite materials
    Solid State Phenomena 151
    Trans Tech Publications, Durnten-Zurich, p. 183 - 189
    Volltext (URL)

2005 (2)

  • Römpler, H., Sangkuhl, K., Busch, W., Schöneberg, T., Schulz, A., (2005):
    Structural evolution of the V-receptor in mammals
    Naunyn-Schmiedebergs Arch. Pharmacol. 371 (Suppl. 1), R15
  • Sangkuhl, K., Römpler, H., Busch, W., Karges, B., Schöneberg, T., (2005):
    Nephrogenic diabetes insipidus caused by mutation of Tyr205: A key residue of V2 vasopressin receptor function
    Hum. Mutat. 25 (5), 505
    Volltext (URL)