Dr. Saskia Trump

Kontakt

Dr. Saskia Trump

Wissenschaftlerin und Leiterin der "Cellular System Analysis- Research Group"

Department Umweltimmunologie
Helmholtz-Zentrum für Umweltforschung - UFZ
Permoserstr. 15
04318 Leipzig

Tel.: +49 341 235-1550
Fax: +49 341 235-1787

Dr. Saskia Trump

Research Interests



Curriculum vitae / Scientific career

1994 - 1999

Student of Chemistry, University Bremen

Diploma thesis in medical chemistry (10/1999):
“NMR-spectroscopic analysis of newborn urine"

11/1999 - 05/2003

PhD-student, University Bremen, Department of Chemistry with the award of the Central Committee of the Academic Senate for the organisation of research and young scientific academics (FNK)


PhD thesis:
“NMR-spectroscopic body fluids measurements"

08/2003 - 06/2005

Postdoctoral Research Fellow, University of Colorado Health Sciences Center, Department of Anesthesiology, Denver/USA

07/2005 - 12/2006

Tenure Track Assistant Professor, University of Colorado Health Sciences Center, Department of Anesthesiology, Denver/USA

10/2007 - 02/2008

Scientist at the Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Immunology (Dr. Irina Lehmann)

02/2008 - 12/2008

Sabbatical term: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland/USA

12/2008 - 12/2012

Experimental coordinator of “contaminant molecule to cellular response: predictive model development” for the Alliance of Helmholtz for system biology at the Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Immunology (Dr. Irina Lehmann)

since 12/2012

Head of the research group "Cellular System Analysis" at the Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Immunology (Dr. Irina Lehmann)

Grants

2015 - 2018

GlioPATH (BMBF e:Med Initiative PI of GlioPATH)


Publications

Inhalt:

2017 (7)
2016 (3)
2015 (2)
2014 (1)
2013 (3)
2011 (7)
2010 (2)
2009 (1)
2007 (3)
2006 (2)

Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.

2017 (7)

  • Dewi, D.L., Mohapatra, S.R., Cabañes, S.B., Adam, I., Patterson, L.F.S., Berdel, B., Kahloon, M., Thürmann, L., Loth, S., Heilmann, K., Weichenhan, D., Mücke, O., Heiland, I., Wimberger, P., Kuhlmann, J.D., Kellner, K.-H., Schott, S., Plass, C., Platten, M., Gerhäuser, C., Trump, S., Opitz, C.A., (2017):
    Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer
    Oncoimmunology 6 (2), e1274477
    Volltext (URL)
  • Dewi, D.L., Mohapatra, S., Wimberger, P., Kuhlmann, J.D., Schott, S., Kellner, K.-H., Gerhauser, C., Trump, S., Opitz, C.A., (2017):
    Epigenetic regulation of indoleamine-2,3-dioxygenase 1 expression in human breast cancer
    Breast 32 (Suppl. 1), S31 - S32
    Volltext (URL)
  • Englich, B., Herberth, G., Rolle-Kampczyk, U., Trump, S., Röder, S., Borte, M., Stangl, G.I., von Bergen, M., Lehmann, I., Junge, K.M., (2017):
    Maternal cytokine status may prime the metabolic profile and increase risk of obesity in children
    Int. J. Obes. 41 (9), 1440 - 1446
    Volltext (URL)
  • Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F., (2017):
    From the exposome to mechanistic understanding of chemical-induced adverse effects
    Environ. Int. 99 , 97 - 106
    Volltext (URL)
  • Jahreis, S., Trump, S., Bauer, M., Bauer, T., Thürmann, L., Feltens, R., Wang, Q., Gu, L., Grützmann, K., Röder, S., Averbeck, M., Weichenhan, D., Plass, C., Sack, U., Borte, M., Dubourg, V., Schüürmann, G., Simon, J.C., von Bergen, M., Hackermüller, J., Eils, R., Lehmann, I., Polte, T., (2017):
    Maternal phthalate exposure promotes allergic airway inflammation over 2 generations via epigenetic modifications
    J. Allergy Clin. Immunol.
    Volltext (URL)
  • Trump, S., Klos, M., Gu, L., Bauer, T., Ishaque, N., Thurmann, L., Bieg, M., Bauer, M., Gu, Z., Borte, M., Mallm, J.-P., Roder, S., Herrmann, C., Rippe, K., Lehmann, I., Eils, R., (2017):
    Asthma development in early childhood is associated with enhancer reprogramming
    Am. J. Respir. Crit. Care Med. 195 , A4910
    Volltext (URL)
  • Winter, M., Thürmann, L., Gu, Z., Schüürmann, G., Herberth, G., Hinz, D., von Bergen, M., Harms, H., Olek, S., Röder, S., Borte, M., Eils, R., Lehmann, I., Trump, S., (2017):
    The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke–associated atopic dermatitis
    J. Allergy Clin. Immunol. 140 (2), 603 - 605
    Volltext (URL)
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2016 (3)

  • Bauer, T., Trump, S., Ishaque, N., Thürmann, L., Gu, L., Bauer, M., Bieg, M., Gu, Z., Weichenhan, D., Mallm, J.-P., Röder, S., Herberth, G., Takada, E., Mücke, O., Winter, M., Junge, K.M., Grützmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Geörg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C., Eils, R., Lehmann, I., (2016):
    Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children
    Mol. Syst. Biol. 12 (3), art. 861
    Volltext (URL)
  • Junge, K.M., Bauer, T., Geissler, S., Hirche, F., Thürmann, L., Bauer, M., Trump, S., Bieg, M., Weichenhan, D., Gu, L., Mallm, J.-P., Ishaque, N., Mücke, O., Röder, S., Herberth, G., Diez, U., Borte, M., Rippe, K., Plass, C., Hermann, C., Stangl, G.I., Eils, R., Lehmann, I., (2016):
    Increased vitamin D levels at birth and in early infancy increase offspring allergy risk—evidence for involvement of epigenetic mechanisms. Letter to the editor
    J. Allergy Clin. Immunol. 137 (2), 610 - 613
    Volltext (URL)
  • Trump, S., Bieg, M., Gu, Z., Thürmann, L., Bauer, T., Bauer, M., Ishaque, N., Röder, S., Gu, L., Herberth, G., Lawerenz, C., Borte, M., Schlesner, M., Plass, C., Diessl, N., Eszlinger, M., Mücke, O., Elvers, H.-D., Wissenbach, D.K., von Bergen, M., Herrmann, C., Weichenhan, D., Wright, R.J., Lehmann, I., Eils, R., (2016):
    Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation
    Sci. Rep. 6 , art. 28616
    Volltext (URL)
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2015 (2)

  • Ali, R., Trump, S., Lehmann, I., Hanke, T., (2015):
    Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene
    J. Biophotonics 8 (5), 361 - 371
    Volltext (URL)
  • Kalkhof, S., Dautel, F., Loguercio, S., Baumann, S., Trump, S., Jungnickel, H., Otto, W., Rudzok, S., Potratz, S., Luch, A., Lehmann, I., Beyer, A., von Bergen, M., (2015):
    Pathway and time-resolved benzo[a]pyrene toxicity on Hepa1c1c7 cells at toxic and subtoxic exposure
    J. Proteome Res. 14 (1), 164 - 182
    Volltext (URL)
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2014 (1)

  • Litzenburger, U.M., Opitz, C.A., Sahm, F., Rauschenbach, K.J., Trump, S., Winter, M., Ott, M., Ochs, K., Lutz, C., Liu, X., Anastasov, N., Lehmann, I., Höfer, T., von Deimling, A., Wick, W., Platten, M., (2014):
    Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
    Oncotarget 5 (4), 1038 - 1051
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2013 (3)

  • Mai, J., Trump, S., Lehmann, I., Attinger, S., (2013):
    Parameter importance in FRAP acquisition and analysis: a simulation approach
    Biophys. J. 104 (9), 2089 - 2097
    Volltext (URL)
  • Murugaiyan, J., Rockstroh, M., Wagner, J., Baumann, S., Schorsch, K., Trump, S., Lehmann, I., von Bergen, M., Tomm, J.M., (2013):
    Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism
    Toxicol. Appl. Pharmacol. 269 (3), 307 - 316
    Volltext (URL)
  • Reiprich, M., Rudzok, S., Schütze, N., Simon, J.C., Lehmann, I., Trump, S., Polte, T., (2013):
    Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model
    Allergy 68 (4), 481 - 489
    Volltext (URL)
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2011 (7)

  • Biddie, S.C., John, S., Sabo, P.J., Thurman, R.E., Johnson, T.A., Schiltz, R.L., Miranda, T.B., Sung, M.H., Trump, S., Lightman, S.L., Vinson, C., Stamatoyannopoulos, J.A., Hager, G.L., (2011):
    Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
    Mol. Cell 43 (1), 145 - 155
    Volltext (URL)
  • Dautel, F., Kalkhof, S., Trump, S., Lehmann, I., Beyer, A., von Bergen, M., (2011):
    Large-scale 2-D DIGE studies - guidelines to overcome pitfalls and challenges along the experimental procedure
    Journal of Integrated OMICS 1 (1), 170 - 179
    Volltext (URL)
  • Dautel, F., Kalkhof, S., Trump, S., Michaelson, J., Beyer, A., Lehmann, I., von Bergen, M., (2011):
    DIGE-based protein expression analysis of B[a]P-exposed hepatoma cells reveals a complex stress response including alterations in oxidative stress, cell cycle control, and cytoskeleton motility at toxic and subacute concentrations
    J. Proteome Res. 10 (2), 379 - 393
    Volltext (URL)
  • Kruber, P., Trump, S., Behrens, J., Lehmann, I., (2011):
    T-2 toxin is a cytochrome P450 1A1 inducer and leads to MAPK/p38- but not aryl hydrocarbon receptor-dependent interleukin-8 secretion in the human intestinal epithelial cell line Caco-2
    Toxicology 284 (1-3), 34 - 41
    Volltext (URL)
  • Mai, J., Trump, S., Ali, R., Schiltz, R.L., Hager, G., Hanke, T., Lehmann, I., Attinger, S., (2011):
    Are assumptions about the model type necessary in reaction-diffusion modeling? A FRAP application
    Biophys. J. 100 (5), 1178 - 1188
    Volltext (URL)
  • Michaelson, J., Trump, S., Rudzok, S., Gräbsch, C., Madureira, D.J., Dautel, F., Mai, J., Attinger, S., Schirmer, K., von Bergen, M., Lehmann, I., Beyer, A., (2011):
    Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure
    BMC Genomics 12 , art. 502
    Volltext (URL)
  • Opitz, C.A., Litzenburger, U.M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., Jugold, M., Guillemin, G.J., Miller, C.L., Lutz, C., Radlwimmer, B., Lehmann, I., von Deimling, A., Wick, W., Platten, M., (2011):
    An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
    Nature 478 (7368), 197 - 203
    Volltext (URL)
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2010 (2)

  • Elitok, S., Trump, S., Hampl, H., Leibfritz, D., Kettritz, R., Luft, F.C., (2010):
    Recurrent metabolic acidosis in a dialysis patient
    Kidney Int. 78 (2), 425 - 426
    Volltext (URL)
  • Faisal, S., Lichtenberg, G., Trump, S., Attinger, S., (2010):
    Structural properties of continuous representations of Boolean functions for gene network modelling
    Automatica 46 (12), 2047 - 2052
    Volltext (URL)
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2009 (1)

  • John, S., Johnson, T.A., Sung, M.H., Biddie, S.C., Trump, S., Koch-Paiz, C.A., Davis, S.R., Walker, R., Meltzer, P., Hager, G.L., (2009):
    Kinetic complexity of the global response to glucocorticoid receptor action
    Endocrinology 150 (4), 1766 - 1774
    Volltext (URL)
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2007 (3)

  • Laudi, S., Steudel, W., Jonscher, K., Schöning, W., Schniedewind, B., Kaisers, U., Christians, U., Trump, S., (2007):
    Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension
    Proteomics 7 (14), 2469 - 2478
    Volltext (URL)
  • Laudi, S., Trump, S., Schmitz, V., West, J., McMurtry, I.F., Mutlak, H., Christians, U., Weimann, J., Kaisers, U., Steudel, W., (2007):
    Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin
    Am. J. Physiol.-Lung Cell. Mol. Physiol. 293 (3), L630 - L638
    Volltext (URL)
  • Laudi, S., Weimann, J., Haschke, M., Trump, S., Schmitz, V., Christians, U., Kaisers, U., Steudel, W., (2007):
    Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine
    J. Physiol. Pharmacol. 58 (1), 19 - 32
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2006 (2)

  • Christians, U., Strom, T., Zhang, Y.L., Steudel, W., Schmitz, V., Trump, S., Haschke, M., (2006):
    Active drug transport of immunosuppressants - New insights for pharmacokinetics and pharmacodynamics
    Ther. Drug Monit. 28 (1), 39 - 44
    Volltext (URL)
  • Trump, S., Laudi, S., Unruh, N., Goelz, R., Leibfritz, D., (2006):
    H-1-NMR metabolic profiling of human neonatal urine
    Magn. Reson. Mat. Phys. Biol. Med. 19 (6), 305 - 312
    Volltext (URL)
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