Details zur Publikation |
Kategorie | Textpublikation |
Referenztyp | Zeitschriften |
DOI | 10.2174/092986610790780314 |
Titel (primär) | Interactions of ginkgolides A and B with a recombinant human prion protein |
Autor | Georgieva, D.; Redecke, L.; von Bergen, M.; Genov, N.; Betzel, C. |
Quelle | Protein and Peptide Letters |
Erscheinungsjahr | 2010 |
Department | PROTEOM |
Band/Volume | 17 |
Heft | 3 |
Seite von | 399 |
Seite bis | 404 |
Sprache | englisch |
Keywords | Three-dimensional structure; structural transformation; ginkgolide; prion protein; protein misfolding |
Abstract | In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure. |
dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=9989 |
Georgieva, D., Redecke, L., von Bergen, M., Genov, N., Betzel, C. (2010): Interactions of ginkgolides A and B with a recombinant human prion protein Protein Pept. Lett. 17 (3), 399 - 404 10.2174/092986610790780314 |