Details zur Publikation
Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.bbrc.2004.11.124
Titel (primär) Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Autor Zierau, O.; Hamann, J.; Tischer, S.; Schwab, P.; Metz, P.; Vollmer, G.; Gutzeit, H.O.; Scholz, S. ORCID logo
Quelle Biochemical and Biophysical Research Communications
Erscheinungsjahr 2005
Department ZELLTOX
Band/Volume 326
Heft 4
Seite von 909
Seite bis 916
Sprache englisch
Keywords Phytoestrogens; Naringenin; Genistein; Sex reversal; Yeast screen assay; Vitellogenin; Medaka; MVLN cells; Estrogen receptor
Abstract The estrogenic activity of several intermediary plant compounds has raised concern about possible risks of unwanted interference with endocrine regulation, but on the other hand there are potential medical benefits, in particular in treatment of menopausal symptoms or cancer. In the present study, we compare the estrogenic effects of phytoestrogens naringenin, 8-prenylnaringenin, 6-(1,1-dimethylallyl)naringenin, and the synthetic 4'-acetyl-7-prenyloxynaringenin. Two mammalian in vitro systems and a fish in vivo system were used to study the estrogenic properties with reference to genistein, 17-ß-estradiol or ethynylestradiol. Strong differences were observed between the mammalian in vitro and the fish in vivo test system. In the medaka sex reversal/vtg gene expression assay no estrogenic effects of the naringenin-type flavonoids were observed, while mammalian in vitro systems showed a similar and graded response to the test compounds.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=3916
Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H.O., Scholz, S. (2005):
Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Biochem. Biophys. Res. Commun. 326 (4), 909 - 916 10.1016/j.bbrc.2004.11.124