Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.jaci.2006.07.014 |
| Titel (primär) | Direct evidence for a critical role of CD30 in the development of allergic asthma |
| Autor | Polte, T.; Behrendt, A.K.; Hansen, G. |
| Quelle | Journal of Allergy and Clinical Immunology |
| Erscheinungsjahr | 2006 |
| Department | IMMU |
| Band/Volume | 118 |
| Heft | 4 |
| Seite von | 942 |
| Seite bis | 948 |
| Sprache | englisch |
| Keywords | Asthma; costimulation; TH2 cells; CD30; immunotherapy |
| Abstract | Background: CD30 is a costimulatory molecule belonging to the TNF receptor superfamily that is expressed on activated T and B cells. Several studies have demonstrated a positive correlation between expression of CD30 or increased levels of soluble CD30 and the development and severity of allergic diseases. However, thus far, the evidence for a role of CD30 in allergic diseases, such as asthma, is only indirect. Objective: The aim of the study was to directly investigate the role of CD30 in a murine asthma model. Methods: CD30-deficient (B6.129P2-Tnfrsf8(tm1Mak)/J) and wild-type (WT) mice were immunized to ovalbumin (OVA) to induce an asthma-like phenotype and compared in our murine asthma model. Moreover, CD30/CD30 ligand signaling was blocked in OVA-immunized WT animals by using mAbs against CD30 receptor and its ligand, CD153. Results: The absence of CD30 in OVA-immunized CD30-deficient mice resulted in significantly reduced airway inflammation, serum IgE levels, and T(H)2 cytokine levels. The same effect was observed when CD30/CD153 signaling was blocked in OVA-immunized WT animals with mAbs against CD30 or CD30 ligand. Conclusion: Our results directly demonstrate that CD30/CD153 interaction plays an important role in the induction of TH2 cell-mediated allergic asthma. Clinical implications: These findings provide evidence for a role of the costimulatory molecule CD30 in allergic asthma |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2919 |
| Polte, T., Behrendt, A.K., Hansen, G. (2006): Direct evidence for a critical role of CD30 in the development of allergic asthma J. Allergy Clin. Immunol. 118 (4), 942 - 948 10.1016/j.jaci.2006.07.014 |
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