Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.4049/jimmunol.1501599 |
| Titel (primär) | Allergen-induced IL-6 regulates IL-9/IL-17A balance in CD4+ T cells in allergic airway inflammation |
| Autor | Schütze, N.; Trojandt, S.; Kuhn, S.; Tomm, J.M.; von Bergen, M.; Simon, J.C.; Polte, T. |
| Quelle | Journal of Immunology |
| Erscheinungsjahr | 2016 |
| Department | IMMU; MOLSYB |
| Band/Volume | 197 |
| Heft | 7 |
| Seite von | 2653 |
| Seite bis | 2664 |
| Sprache | englisch |
| UFZ Querschnittsthemen | RU3; |
| Abstract | IL-9–secreting Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases. To what extent IL-9–producing cells are induced or regulated by sensitization with naturally occurring allergens is not yet clear. Naturally occurring allergens are capable of inducing IL-6 production in dendritic cells (DCs). Whether allergen-induced IL-6 supports a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 differentiation is not finally resolved. Therefore, in the present study we have investigated the impact of IL-6 on the Th9/Th17 balance depending on the predominant cytokine milieu and, additionally, in vivo using a DC-driven murine asthma model. In vitro, IL-6 increases Th9 cells under strong IL-4 and TGF-β activation, whereas under moderate IL-4 and TGF-β activation the presence of IL-6 shifts naive CD4+ cells to Th17 cells. To induce allergic airway inflammation, OVA-pulsed DCs from IL-6–deficient or wild-type donors were adoptively transferred into BALB/c mice. Recipients receiving IL-6–producing wild-type DCs showed a significant decrease of Th9- and IL-4–producing Th2 cells but an increase of Th17 cells in lung tissue in comparison with recipients sensitized with IL-6–deficient DCs. Our data suggest that the IL-6–mediated reduction of Th2-related IL-4 leads to a decline of the Th9 immune response and allows Th17 differentiation |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17852 |
| Schütze, N., Trojandt, S., Kuhn, S., Tomm, J.M., von Bergen, M., Simon, J.C., Polte, T. (2016): Allergen-induced IL-6 regulates IL-9/IL-17A balance in CD4+ T cells in allergic airway inflammation J. Immunol. 197 (7), 2653 - 2664 10.4049/jimmunol.1501599 |
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