Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.jaci.2007.02.017
Titel (primär) Longitudinal study on cat allergen exposure and the development of allergy in young children
Autor Chen, C.M.; Rzehak, P.; Zutavern, A.; Fahlbusch, B.; Bischof, W.; Herbarth, O.; Borte, M.; Lehmann, I.; Behrendt, H.; Krämer, U.; Wichmann, H.-E.; Heinrich, J.; LISA Study Group,
Quelle Journal of Allergy and Clinical Immunology
Erscheinungsjahr 2007
Department IMMU; EXPOEPID
Band/Volume 119
Heft 5
Seite von 1148
Seite bis 1155
Sprache englisch
Keywords Allergy; cats; children; cohort study; house dust; ownership; sensitization
Abstract Background: The influence of cat allergen exposure in early childhood on the development of sensitization and allergic diseases is complex. Little is known about the natural course of the sensitization development within individuals.Objective: We investigated the association between cat allergen exposure in infancy and cat ownership and cat contact during childhood and the development of cat sensitization and allergic diseases up to age 6 years using a longitudinal analysis approach.Methods: Overall, 2166 children from an ongoing birth cohort study were included in the analysis. House dust samples were collected 3 months after birth. Cat allergen levels were extracted. Blood samples were collected when the children were 2 and 6 years old. Information on the allergic symptoms of children and doctor-diagnosed allergic disease were collected at each follow-up using questionnaires.Results: Cat allergen exposure in infancy was positively associated with sensitization at age 2 years but not at age 6 years. No associations existed between cat allergen exposure in infancy and allergic symptoms and diseases up to age 6 years. Cumulative allergen exposure from cat ownership and regular cat contact increased the risk of cat sensitization up to age 6 years.Conclusion: Cat allergen exposure in infancy increases the risk of sensitization development in early childhood but not in school-age children. Cumulative allergen exposure from cat ownership and regular cat contact during childhood contribute to sensitization development up to school age. Clinical implications: Cat allergen avoidance at home alone might be not effective to prevent the development of allergic sensitization in young children.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=1702
Chen, C.M., Rzehak, P., Zutavern, A., Fahlbusch, B., Bischof, W., Herbarth, O., Borte, M., Lehmann, I., Behrendt, H., Krämer, U., Wichmann, H.-E., Heinrich, J., LISA Study Group, (2007):
Longitudinal study on cat allergen exposure and the development of allergy in young children
J. Allergy Clin. Immunol. 119 (5), 1148 - 1155 10.1016/j.jaci.2007.02.017