Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1002/jbio.201300170 |
| Volltext | Shareable Link |
| Titel (primär) | Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene |
| Autor | Ali, R.; Trump, S.; Lehmann, I.; Hanke, T. |
| Quelle | Journal of Biophotonics |
| Erscheinungsjahr | 2015 |
| Department | IMMU |
| Band/Volume | 8 |
| Heft | 5 |
| Seite von | 361 |
| Seite bis | 371 |
| Sprache | englisch |
| Supplements | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjbio.201300170&file=jbio201300170-sup-0001-author-biographies.pdf |
| Keywords | Live cell imaging; Benzo[a]pyrene; 2-Photon; Confocal microscopy |
| UFZ Querschnittsthemen | RU3; |
| Abstract | This study investigates the cellular response of murine hepatoma cells to the polycyclic aromatic hydrocarbon benzo[a]pyrene (B[a]P) using two-photon and confocal laser scanning microscopy. The intracellular distribution of B[a]P and the B[a]P/AhR complex was visualized time- and concentration-dependent for up to 48 h of exposure. B[a]P was predominantly found in lipid droplets, endoplasmic reticulum and lysosomes, where B[a]P is collected and forms large aggregates. Changes in mitochondrial membrane potential and bleb formation due to high B[a]P concentrations were observed. The imaging data presented in this study provide new insights into the systemic cellular regulation following B[a]P exposure. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14753 |
| Ali, R., Trump, S., Lehmann, I., Hanke, T. (2015): Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene J. Biophotonics 8 (5), 361 - 371 10.1002/jbio.201300170 |
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