Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1155/2014/182549
Titel (primär) Generation of IL-8 and IL-9 producing CD4+ T cells is affected by Th17 polarizing conditions and AHR ligands
Autor Gasch, M.; Goroll, T.; Bauer, M.; Hinz, D.; Schütze, N.; Polte, T.; Kesper, D.; Simon, J.-C.; Hackermüller, J. ORCID logo ; Lehmann, I.; Herberth, G. ORCID logo
Quelle Mediators of Inflammation
Erscheinungsjahr 2014
Department IMMU; PROTEOM
Seite von 182549
Sprache englisch
UFZ Querschnittsthemen RU3;
Abstract The T helper cell subsets Th1, Th2, Th17, and Treg play an important role in immune cell homeostasis, in host defense, and in immunological disorders. Recently, much attention has been paid to Th17 cells which seem to play an important role in the early phase of the adoptive immune response and autoimmune disease. When generating Th17 cells under in vitro conditions the amount of IL-17A producing cells hardly exceeds 20% while the nature of the remaining T cells is poorly characterized. As engagement of the aryl hydrocarbon receptor (AHR) has also been postulated to modulate the differentiation of T helper cells into Th17 cells with regard to the IL-17A expression we ask how far do Th17 polarizing conditions in combination with ligand induced AHR activation have an effect on the production of other T helper cell cytokines. We found that a high proportion of T helper cells cultured under Th17 polarizing conditions are IL-8 and IL-9 single producing cells and that AHR activation results in an upregulation of IL-8 and a downregulation of IL-9 production. Thus, we have identified IL-8 and IL-9 producing T helper cells which are subject to regulation by the engagement of the AHR.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14744
Gasch, M., Goroll, T., Bauer, M., Hinz, D., Schütze, N., Polte, T., Kesper, D., Simon, J.-C., Hackermüller, J., Lehmann, I., Herberth, G. (2014):
Generation of IL-8 and IL-9 producing CD4+ T cells is affected by Th17 polarizing conditions and AHR ligands
Mediat. Inflamm. , 182549 10.1155/2014/182549