Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1126/science.1233521
Titel (primär) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Autor Markle, J.G.M.; Frank, D.N.; Mortin-Toth, S.; Robertson, C.E.; Feazel, L.M.; Rolle-Kampczyk, U.; von Bergen, M.; McCoy, C.D.; Macpherson, A.J.; Danska, J.S.
Quelle Science
Erscheinungsjahr 2013
Department METABOX; PROTEOM
Band/Volume 339
Heft 6123
Seite von 1084
Seite bis 1088
Sprache englisch
UFZ Querschnittsthemen RU3;
Abstract Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. We demonstrate that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D. Transfer of gut microbiota from adult males to immature females altered the recipient's microbiota, resulting in elevated testosterone and metabolomic changes, reduced islet inflammation and autoantibody production, and robust T1D protection. These effects were dependent on androgen receptor activity. Thus, the commensal microbial community alters sex hormone levels and regulates autoimmune disease fate in individuals with high genetic risk.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13487
Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M., Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S. (2013):
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Science 339 (6123 ), 1084 - 1088 10.1126/science.1233521