Melis Muz

Current research

Structure elucidation can be limited for some groups even by liquid chromatography. Therefore diagnostic derivatization is a viable solution to improve selectivity and sensitivity for these compounds.
Compounds containing aromatic amino groups are of widespread occurrence in the environment and many of them exhibit mutagenic of carcinogenic potencies after metabolic activation. However, detection of aromatic amines by LC-HRMS fragmentation is not unambiguously possible. Therefore, a diagnostic derivatization procedure will be developed to label aromatic amines in complex environmental sample extracts using post-column/pre-column derivatization techniques. Based on a comparison with the underivatized sample and characteristic fragment ions it will allow for a straightforward detection of aromatic amines for further identification and isolation. Identified aromatic amines will be analyzed by selected bioassays in order to understand their contribution to the mutagenicity of the sample. The developed method will be applied to the Higher-tier EDA samples based on the outcomes of the European Demonstration Program (EDP).

Expertise

Research interests

• Effect-directed analysis (EDA) of complex environmental contamination
• Non-target screening
• Detection of mutagenic compounds in environmental matrices
• Fate of EDCs in wastewater treatment and aquatic environments
• Sludge minimization and treatment processes
• Advance Oxidation Processes

Curriculum vitae

Presentations

M. Muz, W. Brack, M.Krauss.“ Diagnostic derivatization: A novel approach to identify (aromatic) amines in environmental matrices“, 24th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe 2014), Basel, SWITZERLAND.

M. Muz, S. Ak, O. T. Komesli, C. F. Gökçay. “EDC removal in a lab-scale pre-anaerobic SBR unit”, 13th International Conference on Environmental Science and Technology (CEST 2013), Athens, GREECE.

M. Muz, S. Sönmez, O. T. Komesli, C. F. Gökçay. “Determination of selected natural hormones and endocrine disrupting compounds“, 16th International Symposium on Environmental Pollution and its Impact on Life in the Mediterranean Region MESAEP(2011), Ioannina, GREECE.

M. Muz, S. Sönmez, O. T. Komesli, C. F. Gökçay. “Minimization of Excess Sludge by Pulse Ozonation“ 2. Ulusal Aritma Camurlari Sempozyumu (ACS, 2009), İzmir, TURKEY.

Publications

M. Muz, S. Ak, O. T. Komesli, C. F. Gökçay. “Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.”, Environ. Technol. 2014, 35, 1055-1063.

O. T. Komesli, M. Muz, S. Ak, C. F. Gökçay “Prolonged reuse of domestic wastewater after membrane bioreactor treatment” Desalin. Water Treat. 2014, 1-8.

M. Muz, S. Sönmez, O. T. Komesli, C. F. Gökçay. “An ozone assisted process for treatment of EDC’s in biological sludge”, Chem. Eng. J. 2013, 217, 273-280.

M. Muz, S. Ak, O. T. Komesli, C. F. Gökçay. “Intermittent Ozone Application in Aerobic Sludge Digestion”, OZONE, 2013, 36, 57-64.

S. Ak, M. Muz, O. T. Komesli, C. F. Gökçay. “Enhancement of bio-gas production and xenobiotics degradation during anaerobic sludge digestion by ozone treated feed sludge”, Chem. Eng. J. 2013, 230, 499-505.

Werner Brack, Selvan Govender, Tobias Schulze, Martin Krauss, Meng Hu, Melis Muz, Juliane Hollender, Kristin Schirmer, Jennifer Schollee, Anita Hidasi, Jaroslav Slobodnik, Zuzana Rabova, Selim Ait-Aissa, Manoj Sonavane, Mario Carere, Marja Lamoree, Pim Leonards, Sara Tufi, Xiyu Ouyang, Merijn Schriks, Kevin Thomas, Ana Catarina de Almeida, Jean Froment, Monika Hammers-Wirtz, Marijan Ahel, Sanja Koprivica, Henner Hollert, Thomas-Benjamin Seiler, Carolina Di Paolo, Andrew Tindall and Petra Spirhanzlova, 2013. EDA-EMERGE: an FP7 initial training network to equip the next generation of young scientists with the skills to address the complexity of environmental contamination with emerging pollutants, Environmental Sciences Europe, 25-18.

M. Muz, S. Sönmez, O. T. Komesli, S. Bakırdere, C. F. Gökçay. " Determination of selected natural hormones and endocrine disrupting compounds in domestic wastewater treatment plants by liquid chromatography electrospray ionization tandem mass spectrometry after solid phase extraction" Analyst, 2012, 137, 884-889.

M. S. Sönmez , M. Muz, O. T. Komesli, S. Bakırdere, C. F. Gökçay . “Determination of Selected Endocrine Disrupter Compounds at Trace Levels in Sewage Sludge Samples”, CLEAN, 2012, 40, 980-985.