Optimized Strategies for Risk Assessment
of Industrial Chemicals through Integration
of Non-Test and Test Information

ITS Webtool

SIMPPLE, Tarragona, Spain

The central software outcome of OSIRIS is the OSIRIS webtool. This tool guides in performing ITS on skin sensitisation, repeated dose toxicity, mutagenicity, carcinogenicity, bioconcentration factor, and aquatic toxicity.

The webtool can be accessed here:

Free online registration is required to use the tool:

OSIRIS Webtool

ChemProp

Helmholtz Centre for Environmental Research (UFZ), Department of Ecological Chemistry, Leipzig, Germany

ChemProp (Chemical Properties Estimation Software System) allows for QSAR estimations and structure related database retrieval. The OSIRIS webtool is able to directly access a locally installed ChemProp in order to retrieve information needed in the ITS.

The ChemProp OSIRIS edition is publicly available for free, based on bilateral license agreements. Information on ChemProp and how to obtain a license can be found here:

ACC-HUMANSTEADY 1.0

Gertje Czub, Elham Arbaban, Emma Undeman and Michael McLachlan, Department of Applied Environmental Science, Stockholm University, Sweden

ACC-HUMANsteady is a steady state (fugacity based) model of the bioaccumulation of organic contaminants

The basic inputs to the model are two of the three partition coefficients between air-water, octanol-water and octanol-air, the corresponding heats of phase transfer, degradation rates, and chemical concentrations in air, water, soil and sediment. It also has a built in Level I environmental fate model. This model is coded in Visual Basic for Applications (VBA) and runs within Microsoft Excel. The model has been developed and tested on a 32-bit version of Excel 2007 and on a 64-bit version of Excel 2010. The download comprises the Excel file containing the model, a guide to installing, starting and using ACC-HUMANsteady, and a detailed description of the model structure, the input parameters and the process descriptions in the model.

Download

The download and use is strictly restricted to the conditions mentioned in the documents!


Department of Applied Environmental Science, Stockholm University Svante Arrhenius väg 8, SE-11418 Stockholm, Sweden

DTU Model Suite

DTU Environment, Department of Environmental Engineering, Denmark

The models for ionizable compounds are found on the website of Antonio Franco at DTU. Find there the Koc-models, the Multimedia Activity Model for Ionics MAMI, and the simulation model for ionic compounds in wastewater treatment plants, Activity SimpleTreat.

Models to uptake into plants and to bioaccumulation of ionic compounds are placed on the website of Dr. Stefan Trapp at DTU. Find there Plant Uptake models and the Cell Model.

All these models are implemented in Excel, and are accompanied by description and user instructions.

E-SovTox

National Institute of Chemical Physics and Biophysics (NICPB), Tallinn, Estonia

E-SovTox is a database on main publicly available sources of toxicity data published in Russian language.
Access to E-SovTox will be given by the administrator after agreement of the potential user with the “Terms of use” and filling the online application form.

OSIRIS Finished

The official end of the project was reached in September 2011. We thank all partners for their excellent cooperation. The public report giving an overview on the major achievements has been submitted to the European Commission. For legal reasons, please ask them in case you are interested in obtaining a copy. There are still OSIRIS related publications on their way. The OSIRIS publication page will still be updated, thus you may watch it regularly. However, this news column will no more be updated.

OSIRIS Models and Webtool

The OSIRIS webtool and ChemProp are publicly available

Webtool:
Webtool: ITS start
New users need to sign up for free to use the tool
Webtool: Online registration

ChemProp:
A license agreement is necessary to obtain ChemProp
ChemProp: License agreement download

In general, information, downloads and links concerning software developed within OSIRIS can be found here:
Software overview

OSIRIS Flyer

OSIRIS INTRANET