Research for the Environment

Department of Proteomics

Department of Proteomics , Helmholtz-Zentrum für Umweltforschung - UFZ

Head of the Department:
Prof. Dr. Martin von Bergen
Office:
Christine Becher

phone +49 341 235-1264
fax +49 341 235-1787

Permoserstraße 15
04318 Leipzig, Germany

Proteins are the active player in human cells and in those of all kinds of organisms. Altogether they form what is called the proteome of a cell. The cells produce a specific proteome according to the environmental and developmental circumstances and to the needs of the specific cell line by transcribing the genetic information, stored as DNA, into proteins. Proteins are involved in all physiological processes and therefore are a good aim for reaching a better comprehension of biological processes and diseases. Furthermore, disease affected cells display a different protein pattern than healthy ones and so this protein pattern can be used for diagnostics.

In the Department of Proteomics at the UFZ we will focus on the role of proteins in the origin of environmentally caused diseases like allergy and other pathological changes of the immune system and on unravelling the enzymatic mechanisms of microbial degradation of pollutants. The samples from model systems or patients get analysed in terms of the abundance and modification of the proteome. These investigations will improve the molecular understanding of the cause and course of disease.

This defines the aim of the department of proteomics to obtain an improved understanding of the molecular mechanisms of environmentally caused diseases and biological processes in the environment.

publications

  • Hoeke, H., Roeder, S., Bertsche, T., Lehmann, I., Borte, M., von Bergen, M., Wissenbach, D.K., (2015):
    Monitoring of drug intake during pregnancy by questionnaires and LC-MS/MS drug urine screening: evaluation of both monitoring methods
    Drug Test. Anal.
    full text (url)
  • Hoth, N., Gniese, C., Rakoczy, J., Weber, A., Kümmel, S., Reichel, S., Freese, C., Hache, M., Kassahun, A., Schulz, A., Fischer, H., Mühling, M., Starke, R., Kahnt, R., Vogt, C., Richnow, H.-H., Krüger, M., Schippers, A., Schlömann, M., (2015):
    CO2BioPerm — influence of bio-geochemical CO2-transformation processes on the long-term permeability
    In: Liebscher, A., Münch, U., (eds.)
    Geological Storage of CO2 – Long Term Security Aspects. GEOTECHNOLOGIEN Science Report No. 22
    Advanced Technologies in Earth Sciences
    Springer, Berlin, Heidelberg, p. 73 - 96
    full text (url)
  • Jouy, F., Müller, S.A., Wagner, J., Otto, W., von Bergen, M., Tomm, J.M., (2015):
    Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance
    Proteomics 15 (1), 25 - 33
    full text (url)
  • Kalkhof, S., Dautel, F., Loguercio, S., Baumann, S., Trump, S., Jungnickel, H., Otto, W., Rudzok, S., Potratz, S., Luch, A., Lehmann, I., Beyer, A., von Bergen, M., (2015):
    Pathway and time-resolved benzo[a]pyrene toxicity on Hepa1c1c7 cells at toxic and subtoxic exposure
    J. Proteome Res. 14 (1), 164 - 182
    full text (url)
  • Kostelnik, K.B., Els-Heindl, S., Klöting, N., Baumann, S., von Bergen, M., Beck-Sickinger, A.G., (2015):
    High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry
    Bioorg. Med. Chem.
    full text (url)
  • Pöritz, M., Schiffmann, C.L., Hause, G., Heinemann, U., Seifert, J., Jehmlich, N., von Bergen, M., Nijenhuis, I., Lechner, U., (2015):
    Dehalococcoides mccartyi strain DCMB5 respires a broad spectrum of chlorinated aromatic compounds
    Appl. Environ. Microb. 81 (2), 587 - 596
    full text (url)