Dr. Till Luckenbach

Dr. Till Luckenbach

Address:
Permoser Str. 15
04318 Leipzig
Germany

Building: 6.0
Room: 229
Phone: +49 341 235 1514

Dr. Till Luckenbach


Curriculum Vitae

Till Luckenbach, a molecular ecotoxicologist, is a senior researcher at the Department Bioanalytical Ecotoxicology. He works at the UFZ since 2006. Luckenbach studied biology at the University of Tübingen, where in 2002 he also received his doctorate. In 2002 he was a postdoc at the Max-Planck Institute for Developmental Biology in Tübingen, and, from 2002-2005, at Hopkins Marine Station of Stanford University in Pacific Grove, CA.
Funding for Till Luckenbach`s work was obtained from various sources, including the State of Baden-Württemberg (PhD fellowship), the German Academic Exchange Service (DAAD; PhD and postdoc fellowships, bi-national exchanges with Croatia (Dr. Tvrtko Smital, RBI) and Spain (Dr. Barata, CSIC)), the Deutsche Forschungsgemeinschaft (DFG; postdoc fellowship, early career grant), the Helmholtz Association (Helmholtz-Russia Joint Research Group with partners Irkutsk State University, Alfred-Wegener Institute, Bremerhaven, University of Leipzig) and the UFZ (joint project of five UFZ departments).
Till Luckenbach received the SETAC Best Publication Award 2006

Luckenbach`s research interest is in molecular mechanisms that control the uptake of chemicals from the outside and interactions of environmental contaminants with this system. One focus of his work is on molecular "pumps" located in the outer membrane of cells. These pumps are transporter proteins that prevent toxic chemicals from accumulating inside the cell. Action of these proteins confers resistance of cells against a broad range of toxic chemicals, which is called multixenobiotic resistance or MXR. These transporters are important determinants of toxicokinetics of many chemicals. Luckenbach develops tests to study these transporters and study interaction of environmental chemicals with this defensive mechanism. A problem arising from such interaction could be that function of the transporter proteins is impaired and they lose some of their protective power. Study systems include the zebrafish embryo, marine and freshwater invertebrates and cellular systems. Various chemical (such as chemical uptake) and biological aspects (such as joint actions of chemicals in a mixture) with regard to active transport mechanisms are addressed in collaborations within the Biotox department and with colleagues from other departments.
Some of these aspects are currently explored in a field-related project at Lake Baikal in Eastern Siberia. The lake is inhabited by a unique, species-rich endemic fauna and it is a question of high interest how this fauna is affected by the current rapid environmental changes regarding water chemistry and climate.

Publications

2016 (3)

  • Faria, M., Pavlichenko, V.V., Burkhardt-Medicke, K., Soares, A.M.V.M., Altenburger, R., Barata, C., Luckenbach, T., (2016):
    Use of a combined effect model approach for discriminating between ABCB1- and ABCC1-type efflux activities in native bivalve gill tissue
    Toxicol. Appl. Pharmacol. 297 , 56 - 67
    full text (url)
  • Jakob, L., Axenov-Gribanov, D.V., Gurkov, A.N., Ginzburg, M., Bedulina, D.S., Timofeyev, M.A., Luckenbach, T., Lucassen, M., Sartoris, F.J., Pörtner, H.-O., (2016):
    Lake Baikal amphipods under climate change: thermal constraints and ecological consequences
    Ecosphere 7 (3), art. e01308
    full text (url)
  • Keiter, S., Burkhardt-Medicke, K., Wellner, P., Kais, B., Färber, H., Skutlarek, D., Engwall, M., Braunbeck, T., Keiter, S.H., Luckenbach, T., (2016):
    Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos?
    Sci. Total Environ. 548–549 , 317 - 324
    full text (url)

2015 (5)

  • Hachicho, N., Reithel, S., Miltner, A., Heipieper, H.J., Küster, E., Luckenbach, T., (2015):
    Body mass parameters, lipid profiles and protein contents of zebrafish embryos and effects of 2,4-dinitrophenol exposure
    PLOS One 10 (8), e0134755
    full text (url)
  • Kurth, D., Brack, W., Luckenbach, T., (2015):
    Is chemosensitisation by environmental pollutants ecotoxicologically relevant?
    Aquat. Toxicol. 167 , 134 - 140
    full text (url)
  • Luckenbach, T., Bedulina, D.S., Timofeyev, M., (2015):
    Is the endemic fauna of Lake Baikal affected by global change?
    In: Karthe, D., Chalov, S.R., Kasimov, N.S., Kappas, M., (eds.)
    Water and environment in the Selenga-Baikal Basin : international research cooperation for an ecoregion of global relevance
    Erdsicht : Einblicke in geographische und geoinformationstechnische Arbeitsweisen 23
    Ibidem-Verlag, Stuttgart, p. 219 - 235
  • Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R., (2015):
    What determines chemical uptake by the zebrafish embryo model?
    Toxicol. Lett. 238 (2, Suppl.), S54
    full text (url)
  • Pavlichenko, V.V., Protopopova, M.V., Timofeyev, M., Luckenbach, T., (2015):
    Identification of a putatively multixenobiotic resistance related Abcb1 transporter in amphipod species endemic to the highly pristine Lake Baikal
    Environ. Sci. Pollut. Res. 22 (7), 5453 - 5468
    full text (url)

2014 (5)

  • Bedulina, D.S., Takhteev, V.V., Pogrebnyak, S.G., Govorukhina, E.B., Madyarova, E.V., Lubyaga, Y.A., Vereshchagina, K.P., Timofeyev, M.A., Luckenbach, T., (2014):
    On Eulimnogammarus messerschmidtii, sp. n. (Amphipoda: Gammaridea) from Lake Baikal, Siberia, with redescription of E. cyanoides (Sowinsky) and remarks on taxonomy of the genus Eulimnogammarus
    Zootaxa 3838 (5), 518 - 544
    full text (url)
  • Campos, B., Altenburger, R., Gómez, C., Lacorte, S., Piña, B., Barata, C., Luckenbach, T., (2014):
    First evidence for toxic defense based on the multixenobiotic resistance (MXR) mechanism in Daphnia magna
    Aquat. Toxicol. 148 , 139 - 151
    full text (url)
  • Luckenbach, T., Fischer, S., Sturm, A., (2014):
    Current advances on ABC drug transporters in fish
    Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 165 , 28 - 52
    final draft (pdf)
  • Protopopova, M.V., Pavlichenko, V.V., Menzel, R., Putschew, A., Luckenbach, T., Steinberg, C.E.W., (2014):
    Contrasting cellular stress responses of Baikalian and Palearctic amphipods upon exposure to humic substances: environmental implications
    Environ. Sci. Pollut. Res. 21 (24), 14124 - 14137
    full text (url)
  • Rivarola-Duarte, L., Otto, C., Jühling, F., Schreiber, S., Bedulina, D.S., Jakob, L., Gurkov, A., Axenov-Gribanov, D., Sahyoun, A.H., Lucassen, M., Hackermüller, J., Hoffmann, S., Sartoris, F., Pörtner, H.-O., Timofeyev, M., Luckenbach, T., Stadler, P.F., (2014):
    A first glimpse at the genome of the Baikalian amphipod Eulimnogammarus verrucosus
    J. Exp. Zool. Part B 322 (3), 177 - 189
    full text (url)

2013 (4)

  • Bedulina, D.S., Evgen'ev, M.B., Timofeyev, M.A., Protopopova, M.V., Garbuz, D.G., Pavlichenko, V.V., Luckenbach, T., Shatilina, Z.M., Axenov-Gribanov, D.V., Gurkov, A.N., Sokolova, I.M., Zatsepina, O.G., (2013):
    Expression patterns and organization of the hsp70 genes correlate with thermotolerance in two congener endemic amphipod species (Eulimnogammarus cyaneus and E. verrucosus) from Lake Baikal
    Mol. Ecol. 22 (5), 1416 - 1430
    full text (url)
  • Fischer, S., Klüver, N., Burkhardt-Medicke, K., Pietsch, M., Schmidt, A.-M., Wellner, P., Schirmer, K., Luckenbach, T., (2013):
    Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos
    BMC Biol. 11 , art. 69
    full text (url)
  • Madyarova, E.V., Lubyaga, J.A., Gurkov, A.N., Vereshchagina, K.P., Kondrateva, E.M., Shchapova, E.P., Timofeyev, M.A., Luckenbach, T., Bedulina, D.S., (2013):
    A comparative analysis of hsp70 mRNA and HSP70 protein expression in two distant populations of the Baikal amphipod Eulimnogammarus verrucosus (Gerstf., 1858)
    Journal of Stress Physiology & Biochemistry 9 (4), 345 - 351
    full text (url)
  • Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J., (2013):
    A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
    Regul. Toxicol. Pharmacol. 67 (3), 506 - 530
    full text (url)

2012 (1)

  • Navarro, A., Weißbach, S., Faria, M., Barata, C., Piña, B., Luckenbach, T., (2012):
    Abcb and Abcc transporter homologs are expressed and active in larvae and adults of zebra mussel and induced by chemical stress
    Aquat. Toxicol. 122–123 , 144 - 152
    full text (url)

2011 (2)

  • Faria, M., Navarro, A., Luckenbach, T., Piña, B., Barata, C., (2011):
    Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants
    Aquat. Toxicol. 101 (1), 78 - 87
    full text (url)
  • Fischer, S., Loncar, J., Zaja, R., Schnell, S., Schirmer, K., Smital, T., Luckenbach, T., (2011):
    Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)
    Aquat. Toxicol. 101 (2), 438 - 446
    full text (url)

2010 (3)

  • Brennan, C., Dosch, R., Haramis, A.-P., Luckenbach, T., Martínez-Morales, J.-R., Moro, E., Polok, B., Ramesch, T.M., Russell, C., Argenton, F., Strähle, U., (2010):
    Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010
    Zebrafish 7 (3), 305 - 310
    full text (url)
  • Fischer, S., Pietsch, M., Schirmer, K., Luckenbach, T., (2010):
    Identification of multi-drug resistance associated proteins MRP1 (ABCC1) and MRP3 (ABCC3) from rainbow trout (Oncorhynchus mykiss)
    Mar. Environ. Res. 69 (Suppl. 1), S7 - S10
    full text (url)
  • Zucchi, S., Corsi, I., Luckenbach, T., Bard, S.M., Regoli, F., Focardi, S., (2010):
    Identification of five partial ABC genes in the liver of the Antarctic fish Trematomus bernacchii and sensitivity of ABCB1 and ABCC2 to Cd exposure
    Environ. Pollut. 158 (8), 2746 - 2756
    full text (url)

2008 (5)

  • Epel, D., Luckenbach, T., Stevenson, C.N., MacManus-Spencer, L.A., Hamdoun, A., Smital, T., (2008):
    Efflux transporters: newly appreciated roles in protection against pollutants
    Environ. Sci. Technol. 42 (11), 3914 - 3920
    full text (url)
  • Luckenbach, T., Ahnert, M., Fischer, S., Schirmer, K., (2008):
    Zebrafish embryos are sensitized towards chemicals by efflux transporter inhibitors
    Mar. Environ. Res. 66 (1), 81
    full text (url)
  • Luckenbach, T., Altenburger, R., Epel, D., (2008):
    Teasing apart activities of different types of ABC efflux pumps in bivalve gills using the concepts of independent action and concentration addition
    Mar. Environ. Res. 66 (1), 75 - 76
    full text (url)
  • Luckenbach, T., Epel, D., (2008):
    ABCB- and ABCC-type transporters confer multixenobiotic resistance and form an environment-tissue barrier in bivalve gills
    Am. J. Physiol.-Regul. Integr. Comp. Physiol. 294 , R1919 - R1929
    full text (url)
  • Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Völker, D., (2008):
    The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
    Environ. Sci. Pollut. Res. 15 (5), 394 - 404
    full text (url)

2006 (3)

  • Luckenbach, T., Epel, D., (2006):
    The chemosensitizer problem: Unraveling how musks inhibit efflux transporters in mussels and use of this approach for predicting chemo sensitizing potential
    Mar. Environ. Res. 62 (Suppl. 1), S69 - S70
    full text (url)
  • Smital, T., Sauerborn, R., Zaja, R., Luckenbach, T., Hamdoun, A.M., Epel, D., (2006):
    Multidrug resistance-associated proteins (MRPs) as an integral part of multixenobiotic resistance (MXR) in aquatic organisms
    Mar. Environ. Res. 62 (Suppl. 1), S46 - S47
    full text (url)
  • Stevenson, C.N., MacManus-Spencer, L.A., Luckenbach, T., Luthy, R.G., Epel, D., (2006):
    New perspectives on perfluorochemical ecotoxicology: inhibition and induction of an efflux transporter in the marine mussel, Mytilus californianus
    Environ. Sci. Technol. 40 (17), 5580 - 5585
    full text (url)

2005 (2)

  • Hallare, A.V., Schirling, M., Luckenbach, T., Köhler, H.-R., Triebskorn, R., (2005):
    Combined effects of temperature and cadmium on developmental parameters and biomarker responses in zebrafish (Danio rerio) embryos
    J. Therm. Biol. 30 (1), 7 - 17
    full text (url)
  • Luckenbach, T., Epel, D., (2005):
    Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multidrug transporters
    Environ. Health Perspect. 113 (1), 17 - 24
    full text (url)

2004 (2)

  • Luckenbach, T., Corsi, I., Epel, D., (2004):
    Fatal attraction: synthetic musk fragrances compromise multixenobiotic defense systems in mussels
    Mar. Environ. Res. 58 (2-5), 215 - 219
    full text (url)
  • Smital, T., Luckenbach, T., Sauerborn, R., Hamdoun, A.M., Vega, R.L., Epel, D., (2004):
    Emerging contaminants-pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms
    Mutat. Res.-Fundam. Mol. Mech. Mutagen. 552 (1-2), 101 - 117
    full text (url)

2003 (3)

  • Luckenbach, T., Ferling, H., Gernhofer, M., Köhler, H.-R., Negele, R.D., Pfefferle, E., Triebskorn, R., (2003):
    Developmental and subcellular effects of chronic exposure to sub-lethal concentrations of ammonia, PAH and PCP mixtures in brown trout (Salmo trutta f. fario L.) early life stages
    Aquat. Toxicol. 65 (1), 39 - 54
    full text (url)
  • Luckenbach, T., Kilian, M., Triebskorn, R., Oberemm, A., (2003):
    Assessment of the developmental success of brown trout (Salmo trutta f. fario L.) embryos in two differently polluted streams in Germany
    Hydrobiologia 490 (1-3), 53 - 62
    full text (url)
  • Triebskorn, R., Adam, S., Behrens, A., Beier, S., Böhmer, J., Braunbeck, T., Casper, H., Dietze, U., Gernhöfer, M., Honnen, W., Köhler, H.-R., Körner, W., Konradt, J., Lehmann, R., Luckenbach, T., Oberemm, A., Schwaiger, J., Segner, H., Strmac, M., Schüürmann, G., Siligato, S., Traunspurger, W., (2003):
    Establishing causality between pollution and effects at different levels of biological organization: the VALIMAR project
    Hum. Ecol. Risk Assess. 9 (1), 171 - 194
    full text (url)

2001 (1)

  • Luckenbach, T., Triebskorn, R., Müller, E., Oberemm, A., (2001):
    Toxicity of waters from two streams to early life stages of brown trout (Salmo trutta f. fario L.), tested under semi-field conditions
    Chemosphere 45 (4-5), 571 - 579
    full text (url)

2000 (1)

  • Triebskorn, R., Adam, S., Behrens, A., Beier, S., Böhmer, J., Braunbeck, T., Eckwert, H., Frahne, D., Hartig, K., Honnen, W., Kappus, B., Klingebiel, M., Köhler, H.-R., Konradt, J., Lehmann, R., Luckenbach, T., Oberemm, A., Pawert, M., Schlegel, T., Schramm, M., Schüürmann, G., Schwaiger, J., Segner, H., Siligato, S., Strmac, M., Traunspurger, W., Müller, E., (2000):
    Das BMBF-Verbundprojekt VALIMAR: Ziele, Inhalte, Methoden, Verbundpartner
    In: Fomin, A., Arndt, U., Elsner, D., Klumpp, A., (eds.)
    Bioindikation: Biologische Testverfahren. Beiträge und Diskussion - 2. Hohenheimer Workshop zur Bioindikation am Kraftwerk Altbach-Deizisau, 6.4.1998
    Heimbach, Stuttgart, p. 165 - 168

1999 (3)

  • Luckenbach, T., Adam, S., Behrens, A., Beier, S., Böhmer, J., Braunbeck, T., Dietze, U., Honnen, W., Kappus, B., Klingebiel, M., Knigge, T., Köhler, H.-R., Konradt, J., Lehmann, R., Müller, E., Oberemm, A., Schüürmann, G., Schwaiger, J., Segner, H., Siligato, S., Strmac, M., Traunspurger, W., Triebskorn, R., (1999):
    Das Verbundprojekt Valimar
    In: Böcker, R., (ed.)
    Umweltforschung im Dialog - aktuelle Beiträge aus dem mittleren Neckarraum. Hohenheimer Umwelttagung 31
    p. 79 - 84
  • Luckenbach, T., Kilian, M., Triebskorn, R., Oberemm, A., (1999):
    Fish early life stage tests as a tool to assess embryotoxic potentials in small streams
    J. Aquat. Ecosys. Stress Recov. 8 (3-4), 355 - 370
    full text (url)
  • Luckenbach, T., Triebskorn, R., Müller, E., Oberemm, A., (1999):
    Untersuchungen zur Wirkung anthropogener Gewässerbelastungen auf die Entwicklung von Bachforellen (Salmo trutta fario L.)
    In: Oehlmann, J., Markert, B., (Hrsg.)
    Ökotoxikologie: Ökosystemare Ansätze und Methoden
    ecomed, Landsberg am Lech, S. 399 - 407