Research for the Environment

Dr. Jana Seifert

Dr. Jana Seifert
Group Leader
Microbial Ecology and Biodegradation Group

Department of Proteomics
Helmholtz-Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: +49 341 235 1352
Fax: +49 341 235 1786
jana.seifert@ufz.de

Photo

Research activities and methods

The Microbial Ecology and Biodegradation group focus on the proteome analysis of microbial cultures involved in the degradation of BTEX and chlorinated compounds under aerobic and anaerobic conditions. The recently established protein-based stable isotope probing (Protein-SIP) method is applied to investigate well-defined mixed as well as enrichment cultures by the metabolic incorporation of isotopes using labelled substrates.

Projects

Cooperations

- University Leipzig, Institute Biochemistry
- Friedrich-Schiller University Jena, Applied and Ecological Microbiology
- TU Bergakademie Freiberg, Institute of Bioscience, Environmental Microbiology
- BGR Hannover, Division Geomicorbiology
- Martin-Luther University Halle, Institute of Biology, Division of General Microbiology
- Max-Planck-Institute for Marine Microbiology, Department of Molecular Ecology, Bremen
- Netherlands Institute of Ecology, Department of Microbial Ecology, Wageningen (NL)
- CSIC - Institute of Catalysis, Laboratory of Enzyme Discovery, Madrid (Spain)
- University of Aberdeen, Institute of Biological & Environmental Sciences, Aberdeen (UK)
- University Vienna, Department of Microbial Ecology, Vienna (At)

CV / Scientific Career

since 02/2009

Helmholtz Centre for Environmental Research
Post-Doc at the Department of Proteomics, Group Microbial Ecology and Biodegradation

2005 – 2009

TU Bergakademie Freiberg
Post-Doc at the Department of Bioscience, Environmental Microbiology

2001 –2006

TU Bergakademie Freiberg
PhD student at the Department of Bioscience, Environmental Microbiology
‘Functional and Sequence Diversity of Oxygenases in Biodegradation of Chloroaromatic Compounds – A Challenge for Molecular Biology and Enzymology’

2000 – 2001

Bioclear b.v., Groningen (NL)
Diploma thesis: ‘Detection of Dechlorinators – Molecular Research of the Perchloroethene Degradation Process’

1996 – 2001

TU Bergakademie Freiberg
Diploma Geoecology

Publications

2015 (4)

  • Kümmel, S., Herbst, F.-A., Bahr, A., Duarte, M., Pieper, D.H., Jehmlich, N., Seifert, J., von Bergen, M., Bombach, P., Richnow, H.H., Vogt, C., (2015):
    Anaerobic naphthalene degradation by sulfate-reducing Desulfobacteraceae from various anoxic aquifers
    FEMS Microbiol. Ecol. 91 (3), fiv006
    full text (url)
  • Pöritz, M., Schiffmann, C.L., Hause, G., Heinemann, U., Seifert, J., Jehmlich, N., von Bergen, M., Nijenhuis, I., Lechner, U., (2015):
    Dehalococcoides mccartyi strain DCMB5 respires a broad spectrum of chlorinated aromatic compounds
    Appl. Environ. Microb. 81 (2), 587 - 596
    full text (url)
  • Sachsenberg, T., Herbst, F.-A., Taubert, M., Kermer, R., Jehmlich, N., von Bergen, M., Seifert, J., Kohlbacher, O., (2015):
    MetaProSIP: Automated inference of stable isotope incorporation rates in proteins for functional metaproteomics
    J. Proteome Res. 14 (2), 619 - 627
    full text (url)
  • Tobalina, L., Bargiela, R., Pey, J., Herbst, F.-A., Lores, I., Rojo, D., Barbas, C., Peláez, A.I., Sánchez, J., von Bergen, M., Seifert, J., Ferrer, M., Planes, F.J., (2015):
    Context-specific metabolic network reconstruction of a naphthalene-degrading bacterial community guided by metaproteomic data
    Bioinformatics 31 (11), 1771 - 1779
    full text (url)

2014 (7)

  • Bozinovski, D., Taubert, M., Kleinsteuber, S., Richnow, H.-H., von Bergen, M., Vogt, C., Seifert, J., (2014):
    Metaproteogenomic analysis of a sulfate-reducing enrichment culture reveals genomic organization of key enzymes in the m-xylene degradation pathway and metabolic activity of proteobacteria
    Syst. Appl. Microbiol. 37 (7), 488 - 501
    full text (url)
  • Kleindienst, S., Herbst, F.-A., Stagars, M., von Netzer, F., von Bergen, M., Seifert, J., Peplies, J., Amann, R., Musat, F., Lueders, T., Knittel, K., (2014):
    Diverse sulfate-reducing bacteria of the Desulfosarcina/Desulfococcus clade are the key alkane degraders at marine seeps
    ISME J. 8 , 2029 - 2044
    full text (url)
  • Lieder, S., Jahn, M., Seifert, J., von Bergen, M., Müller, S., Takors, R., (2014):
    Subpopulation-proteomics reveal growth rate, but not cell cycling, as a major impact on protein composition in Pseudomonas putida KT2440
    AMB Express 4 , art. 71
    full text (url)
  • Marozava, S., Röling, W.F.M., Seifert, J., Küffner, R., von Bergen, M., Meckenstock, R.U., (2014):
    Physiology of Geobacter metallireducens under excess and limitation of electron donors. Part I. Batch cultivation with excess of carbon sources
    Syst. Appl. Microbiol. 37 (4), 277 - 286
    full text (url)
  • Marozava, S., Röling, W.F.M., Seifert, J., Küffner, R., von Bergen, M., Meckenstock, R.U., (2014):
    Physiology of Geobacter metallireducens under excess and limitation of electron donors. Part II. Mimicking environmental conditions during cultivation in retentostats
    Syst. Appl. Microbiol. 37 (4), 287 - 295
    full text (url)
  • Schiffmann, C., Hansen, R., Baumann, S., Kublik, A., Nielsen, P.H., Adrian, L., von Bergen, M., Jehmlich, N., Seifert, J., (2014):
    Comparison of targeted peptide quantification assays for reductive dehalogenases by selective reaction monitoring (SRM) and precursor reaction monitoring (PRM)
    Anal. Bioanal. Chem. 406 (1), 283 - 291
    full text (url)
  • Schiffmann, C.L., Jehmlich, N., Otto, W., Hansen, R., Nielsen, P.H., Adrian, L., Seifert, J., von Bergen-Tomm, M., (2014):
    Proteome profile and proteogenomics of the organohalide-respiring bacterium Dehalococcoides mccartyi strain CBDB1 grown on hexachlorobenzene as electron acceptor
    J. Proteomics 98 , 59 - 64
    full text (url)

2013 (16)

  • Bodelier, P.L.E., Meima-Franke, M., Hordijk, C.A., Steenbergh, A.K., Hefting, M.E., Bodrossy, L., von Bergen, M., Seifert, J., (2013):
    Microbial minorities modulate methane consumption through niche partitioning
    ISME J. 7 , 2214 - 2228
    full text (url)
  • Eberlein, C., Estelmann, S., Seifert, J., von Bergen, M., Müller, M., Meckenstock, R.U., Boll, M., (2013):
    Identification and characterization of 2-naphthoyl-coenzyme A reductase, the prototype of a novel class of dearomatizing reductases
    Mol. Microbiol. 88 (5), 1032 - 1039
    full text (url)
  • Ferrer, M., Ruiz, A., Lanza, F., Haange, S.-B., Oberbach, A., Till, H., Bargiela, R., Campoy, C., Segura, M.T., Richter, M., von Bergen, M., Seifert, J., Suarez, A., (2013):
    Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure
    Environ. Microbiol. 15 (1), 211 - 226
    full text (url)
  • Guazzaroni, M.-E., Herbst, F.-A., Lores, I., Tamames, J., Peláez, A.I., López-Cortés, N., Alcaide, M., del Pozo, M.V., Vieites, J.M., von Bergen, M., Gallego, J.L.R., Bargiela, R., López-López, A., Pieper, D.H., Rosselló-Móra, R., Sánchez, J., Seifert, J., Ferrer, M., (2013):
    Metaproteogenomic insights beyond bacterial response to naphthalene exposure and bio-stimulation
    ISME J. 7 , 122 - 136
    full text (url)
  • Herbst, F.-A., Bahr, A., Duarte, M., Pieper, D.H., Richnow, H.-H., von Bergen, M., Seifert, J., Bombach, P., (2013):
    Elucidation of in situ polycyclic aromatic hydrocarbon degradation by functional metaproteomics (protein-SIP)
    Proteomics 13 (18-19), 2910 - 2920
    full text (url)
  • Herbst, F.-A., Taubert, M., Jehmlich, N., Behr, T., Schmidt, F., von Bergen, M., Seifert, J., (2013):
    Sulfur-34S stable isotope labeling of amino acids for quantification (SULAQ34) of proteomic changes in Pseudomonas fluorescens during naphthalene degradation
    Mol. Cell. Proteomics 12 (8), 2060 - 2069
    full text (url)
  • Jahn, M., Seifert, J., Hübschmann, T., von Bergen, M., Harms, H., Müller, S., (2013):
    Comparison of preservation methods for bacterial cells in cytomics and proteomics
    Journal of Integrated OMICS 3 (1), 25 - 33
    full text (url)
  • Jahn, M., Seifert, J., von Bergen, M., Schmid, A., Bühler, B., Müller, S., (2013):
    Subpopulation-proteomics in prokaryotic populations
    Curr. Opin. Biotechnol. 24 (1), 79 - 87
    full text (url)
  • Jechalke, S., Franchini, A., Bastida, F., Bombach, P., Rosell, M., Seifert, J., von Bergen, M., Vogt, C., Richnow, H.H., (2013):
    Analysis of structure, function, and activity of a benzene-degrading microbial community
    FEMS Microbiol. Ecol. 85 (1), 14 - 26
    full text (url)
  • Kung, J.W., Seifert, J., von Bergen, M., Boll, M., (2013):
    Cyclohexanecarboxyl-coenzyme A (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus
    J. Bacteriol. 195 (14), 3193 - 3200
    full text (url)
  • Pérez-Cobas, A.E., Gosalbes, M.J., Friedrichs, A., Knecht, H., Artacho, A., Eismann, K., Otto, W., Rojo, D., Bargiela, R., von Bergen, M., Neulinger, S.C., Däumer, C., Heinsen, F.A., Latorre, A., Barbas, C., Seifert, J., Martins dos Santos, V., Ott, S.J., Ferrer, M., Moya, A., (2013):
    Gut microbiota disturbance during antibiotic therapy: a multi-omic approach
    Gut 62 , 1591 - 1601
    full text (url)
  • Schipp, C.-J., Marco-Urrea, E., Kublik, A., Seifert, J., Adrian, L., (2013):
    Organic cofactors in the metabolism of Dehalococcoides mccartyi strains
    Philos. Trans. R. Soc. B-Biol. Sci. 368 (1616), 20120321
    full text (url)
  • Seifert, J., Herbst, F.-A., Nielsen, P.H., Planes, F.J., Ferrer, M., von Bergen, M., (2013):
    Bioinformatic progress and applications in metaproteogenomics for bridging the gap between genomic sequences and metabolic functions in microbial communities
    Proteomics 13 (18-19), 2786 - 2804
    full text (url)
  • Tang, S., Chan, W.W.M., Fletcher, K.E., Seifert, J., Liang, X., Löffler, F.E., Edwards, E.A., Adrian, L., (2013):
    Functional characterization of reductive dehalogenases using blue native polyacrylamide gel electrophoresis
    Appl. Environ. Microb. 79 (3), 974 - 981
    full text (url)
  • Taubert, M., von Bergen-Tomm, M., Seifert, J., (2013):
    Limitations in detection of 15N incorporation by mass spectrometry in protein-based stable isotope probing (protein-SIP)
    Anal. Bioanal. Chem. 405 (12), 3989 - 3996
    full text (url)
  • von Bergen, M., Jehmlich, N., Taubert, M., Vogt, C., Bastida, F., Herbst, F.-A., Schmidt, F., Richnow, H.-H., Seifert, J., (2013):
    Insights from quantitative metaproteomics and protein-stable isotope probing into microbial ecology
    ISME J. 7 (10), 1877 - 1885
    full text (url)

2012 (13)

  • Baumgarten, T., Sperling, S., Seifert, J., von Bergen, M., Steiniger, F., Wick, L.Y., Heipieper, H.J., (2012):
    Membrane vesicle formation as a multiple-stress response mechanism enhances Pseudomonas putida DOT-T1E cell surface hydrophobicity and biofilm formation
    Appl. Environ. Microb. 78 (17), 6217 - 6224
    full text (url)
  • Bozinovski, D., Herrmann, S., Richnow, H.-H., von Bergen, M., Seifert, J., Vogt, C., (2012):
    Functional analysis of an anaerobic m-xylene-degrading enrichment culture using protein-based stable isotope probing
    FEMS Microbiol. Ecol. 81 (1), 134 - 144
    full text (url)
  • Haange, S.-B., Oberbach, A., Schlichting, N., Hugenholtz, F., Smidt, H., von Bergen, M., Till, H., Seifert, J., (2012):
    Metaproteome analysis and molecular genetics of rat intestinal microbiota reveals section and localisation resolved species distribution and enzymatic functionalities
    J. Proteome Res. 11 (11), 5406 - 5417
    full text (url)
  • Jehmlich, N., Kopinke, F.-D., Lenhard, S., Vogt, C., Herbst, F.-A., Seifert, J., Lissner, U., Völker, U., Schmidt, F., von Bergen, M., (2012):
    Sulfur-36S stable isotope labeling of amino acids for quantification (SULAQ)
    Proteomics 12 (1), 37 - 42
    full text (url)
  • Kermer, R., Hedrich, S., Taubert, M., Baumann, S., Schlömann, M., Johnson, D.B., Seifert, J., (2012):
    Elucidation of carbon transfer in a mixed culture of Acidiphilium cryptum and Acidithiobacillus ferrooxidans using protein-based stable isotope probing
    Journal of Integrated OMICS 2 (1), 37 - 45
    full text (url)
  • Marco-Urrea, E., Seifert, J., von Bergen, M., Adrian, L., (2012):
    Stable isotope peptide mass spectrometry to decipher amino acid metabolism in Dehalococcoides strain CBDB1
    J. Bacteriol. 194 (16), 4169 - 4177
    full text (url)
  • Morris, B.E.L., Herbst, F.-A., Bastida, F., Seifert, J., von Bergen, M., Richnow, H.-H., Suflita, J.M., (2012):
    Microbial interactions during residual oil and n-fatty acid metabolism by a methanogenic consortium
    Environ. Microbiol. Rep. 4 (3), 297 - 306
    full text (url)
  • Oberender, J., Kung, J.W., Seifert, J., von Bergen, M., Boll, M., (2012):
    Identification and characterization of a succinyl-coenzyme A (CoA):benzoate CoA transferase in Geobacter metallireducens
    J. Bacteriol. 194 (10), 2501 - 2508
    full text (url)
  • Reinhold, A., Westermann, M., Seifert, J., von Bergen, M., Schubert, T., Diekert, G., (2012):
    Impact of vitamin B12 on the formation of the tetrachloroethene reductive dehalogenase in Desulfitobacterium hafniense strain Y51
    Appl. Environ. Microb. 78 (22), 8025 - 8032
    full text (url)
  • Seifert, J., Taubert, M., Jehmlich, N., Schmidt, F., Völker, U., Vogt, C., Richnow, H.H., von Bergen, M., (2012):
    Protein-based stable isotope probing (protein-SIP) in functional metaproteomics
    Mass Spectrom. Rev. 31 (6), 683 - 697
    full text (url)
  • Sultana, M., Vogler, S., Zargar, K., Schmidt, A.-C., Saltikov, C., Seifert, J., Schlömann, M., (2012):
    New clusters of arsenite oxidase and unusual bacterial groups in enrichments from arsenic-contaminated soil
    Arch. Microbiol. 194 (7), 623 - 635
    full text (url)
  • Taubert, M., Vogt, C., Wubet, T., Kleinsteuber, S., Tarkka, M.T., Harms, H., Buscot, F., Richnow, H.-H., von Bergen, M., Seifert, J., (2012):
    Protein-SIP enables time-resolved analysis of the carbon flux in a sulfate-reducing, benzene-degrading microbial consortium
    ISME J. 6 (12), 2291 - 2301
    full text (url)
  • Wagner, A., Cooper, M., Ferdi, S., Seifert, J., Adrian, L., (2012):
    Growth of Dehalococcoides mccartyi strain CBDB1 by reductive dehalogenation of brominated benzenes to benzene
    Environ. Sci. Technol. 46 (16), 8960 - 8968
    full text (url)

2011 (9)

  • Bastida, F., Jechalke, S., Bombach, P., Franchini, A.G., Seifert, J., von Bergen, M., Vogt, C., Richnow, H.H., (2011):
    Assimilation of benzene carbon through multiple trophic levels traced by different stable isotope probing methodologies
    FEMS Microbiol. Ecol. 77 (2), 357 - 369
    full text (url)
  • Georgieva, D., Seifert, J., Öhler, M., von Bergen, M., Spencer, P., Arni, R.K., Genov, N., Betzel, C., (2011):
    Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin
    J. Proteome Res. 10 (5), 2440 - 2464
    full text (url)
  • Hedrich, S., Lünsdorf, H., Kleeberg, G., Heide, G., Seifert, J., Schlömann, M., (2011):
    Schwertmannite formation adjacent to bacterial cells in a mine water treatment plant and in pure cultures of ‘Ferrovum myxofaciens’
    Environ. Sci. Technol. 45 (18), 7685 - 7692
    full text (url)
  • Jehmlich, N., Seifert, J., Taubert, M., Schmidt, F., Vogt, C., Richnow, H.H., von Bergen, M., (2011):
    Protein stable isotope probing
    In: Murrell, J.C., Whiteley, A.S., (eds.)
    Stable isotope probing and related technologies
    ASM Press, Washington, DC, p. 71 - 93
  • Kuntze, K., Kiefer, P., Baumann, S., Seifert, J., von Bergen, M., Vorholt, J.A., Boll, M., (2011):
    Enzymes involved in the anaerobic degradation of meta-substituted halobenzoates
    Mol. Microbiol. 82 (3), 758 - 769
    full text (url)
  • Marco-Urrea, E., Paul, S., Khodaverdi, V., Seifert, J., von Bergen, M., Kretzschmar, U., Adrian, L., (2011):
    Identification and characterization of a Re-Citrate synthase in Dehalococcoides strain CBDB1
    J. Bacteriol. 193 (19), 5171 - 5178
    full text (url)
  • Sultana, M., Härtig, C., Planer-Friedrich, B., Seifert, J., Schlömann, M., (2011):
    Bacterial communities in Bangladesh aquifers differing in aqueous arsenic concentration
    Geomicrobiol. J. 28 (3), 198 - 211
    full text (url)
  • Taubert, M., Baumann, S., von Bergen, M., Seifert, J., (2011):
    Exploring the limits of robust detection of incorporation of 13C by mass spectrometry in protein-based stable isotope probing (protein-SIP)
    Anal. Bioanal. Chem. 401 (6), 1975 - 1982
    full text (url)
  • Taubert, M., Jehmlich, N., Vogt, C., Richnow, H.H., Schmidt, F., von Bergen, M., Seifert, J., (2011):
    Time resolved protein-based stable isotope probing (Protein-SIP) analysis allows quantification of induced proteins in substrate shift experiments
    Proteomics 11 (11), 2265 - 2274
    full text (url)

2010 (8)

  • Bastida, F., Rosell, M., Franchini, A.G., Seifert, J., Finsterbusch, S., Jehmlich, N., Jechalke, S., von Bergen, M., Richnow, H.H., (2010):
    Elucidating MTBE degradation in a mixed consortium using a multidisciplinary approach
    FEMS Microbiol. Ecol. 73 (2), 370 - 384
    full text (url)
  • Fetzer, I., Jehmlich, N., Vogt, C., Richnow, H.H., Seifert, J., Harms, H., von Bergen, M., Schmidt, F., (2010):
    Calculation of partial isotope incorporation into peptides measured by mass spectrometry
    BMC Research Notes 3:178
    full text (url)
  • Georgieva, D., Öhler, M., Seifert, J., von Bergen, M., Arni, R.K., Genov, N., Betzel, C., (2010):
    Snake venomic of Crotalus durissus terrificus-correlation with pharmacological activities
    J. Proteome Res. 9 (5), 2302 - 2316
    full text (url)
  • Jehmlich, N., Fetzer, I., Seifert, J., Mattow, J., Vogt, C., Harms, H., Thiede, B., Richnow, H.H., von Bergen, M., Schmidt, F., (2010):
    Decimal place slope: a fast and precise method for quantifying 13C incorporation levels for detecting the metabolic activity of microbial species
    Mol. Cell. Proteomics 9 (6), 1221 - 1227
    full text (url)
  • Jehmlich, N., Kleinsteuber, S., Vogt, C., Benndorf, D., Harms, H., Schmidt, F., von Bergen, M., Seifert, J., (2010):
    Phylogenetic and proteomic analysis of an anaerobic toluene-degrading community
    J. Appl. Microbiol. 109 (6), 1937 - 1945
    full text (url)
  • Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., Bastida, F., von Bergen, M., Richnow, H.-H., Vogt, C., (2010):
    Protein-based stable isotope probing
    Nat. Protoc. 5 (12), 1957 - 1966
    full text (url)
  • Leibeling, S., Taubert, M., Seifert, J., von Bergen, M., Harms, H., Müller, R.H., (2010):
    Adaptation of the herbicide-degrading strain Delftia acidovorans MC1 through carbonylation of RdpA as key enzyme
    J. Biotechnol. 150 (Suppl. 1), S262 - S263
    full text (url)
  • Öhler, M., Georgieva, D., Seifert, J., von Bergen, M., Arni, R.K., Genov, N., Betzel, C., (2010):
    The Venomics of Bothrops alternatus is a Pool of Acidic Proteins with Predominant Hemorrhagic and Coagulopathic Activities
    J. Proteome Res. 9 (5), 2422 - 2437
    full text (url)

2009 (6)

  • Ehinger, S., Seifert, J., Kassahun, A., Schmalz, L., Hoth, N., Schlömann, M., (2009):
    Predominance of Methanolobus spp. and Methanoculleus spp. in the archaeal communities of saline gas field formation fluids
    Geomicrobiol. J. 26 (5), 326 - 338
    full text (url)
  • Gniese, C., Kruger, M., Frerichs, J., Kassahun, A., Hoth, N., Seifert, J., (2009):
    Determination of active microorganisms in the gas reservoir Altmark and their role in CO2 turnover
    Geochim. Cosmochim. Acta 73 (13 Suppl.), A442
    full text (url)
  • Heinzel, E., Hedrich, S., Janneck, E., Glombitza, F., Seifert, J., Schlömann, M., (2009):
    Bacterial diversity in a mine water treatment plant
    Appl. Environ. Microb. 75 (3), 858 - 861
    full text (url)
  • Heinzel, E., Janneck, E., Glombitza, F., Schlömann, M., Seifert, J., (2009):
    Population dynamics of iron-oxidizing communities in pilot plants for the treatment of acid mine waters
    Environ. Sci. Technol. 43 (16), 6138 - 6144
    full text (url)
  • Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., von Bergen, M., Richnow, H.-H., Vogt, C., (2009):
    Comparison of methods for simultaneous identification of bacterial species and determination of metabolic activity by protein-based stable isotope probing (Protein-SIP) experiments
    Rapid Commun. Mass Spectrom. 23 (12), 1871 - 1878
    full text (url)
  • Seifert, J., Jehmlich, N., Schmidt, F., Taubert, M., von Bergen, M., Richnow, H.-H., Vogt, C., (2009):
    Protein-stable isotope probing (Protein-SIP) for simultaneous identification of bacterial species and determination of metabolic activity
    Geochim. Cosmochim. Acta 73 (13 Suppl.), A1191
    full text (url)

2005 (1)

  • Ferraroni, M., Seifert, J., Travkin, V.M., Thiel, M., Kaschabek, S., Scozzafava, A., Golovleva, L., Schlömann, M., Briganti, F., (2005):
    Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation
    J. Biol. Chem. 280 (22), 21144 - 21154
    full text (url)