Research for the Environment

Department Environmental Immunology

Department Environmental Immunology and Core-Facility Studies

Head of the department:
Dr. Irina Lehmann

Office:

Foreign Language Assistant (german/english/french)
Alice Teipelke

Tel.: + 49 341 235-1265
Fax: +49 341 235-1787

Permoserstraße 15
04318 Leipzig

Building 6.0

office hours

monday, wednesday-friday: 10am-14pm

tuesday: 9am-13pm

The Department Environmental Immunology investigates the influence of environmental factors on the human immune system. Epidemiological studies are performed to study how immune responses are modulated by environmental pollutants and life style factors. In addition, in vitro models are used to ascertain the causal links between exposure and immunomodulation, and to characterise the basic molecular mechanisms.

Data gained in vivo from epidemiological studies and in vitro from experimental models are used to elucidate allergies and other diseases caused by environmental factors. Interest is focused on pollutants stemming from indoor sources.

Recent publications

Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R. Hypermutation of the inactive x chromosome is a frequent event in cancer. Cell. 2013 Oct 24;155(3):567-81. Abstract

Weisse K, Lehmann I, Heroux D, Kohajda T, Herberth G, Röder S, von Bergen M, Borte M, Denburg J. The LINA cohort: indoor chemical exposure, circulating eosinophil/basophil (Eo/B) progenitors and early life skin manifestations. Clin Exp Allergy. 2012 Sep;42(9):1337-46.
Abstract

Herberth G, Herzog T, Hinz D, Röder S, Schilde M, Sack U, Diez U, Borte M, Lehmann I. Renovation activities during pregnancy induce a Th2 shift in fetal but not in maternal immune system. Int J Hyg Environ Health. Epub 2012 Aug 1
Abstract

Bönisch U, Böhme A, Kohajda T, Mögel I, Schütze N, von Bergen M, Simon JC, Lehmann I, Polte T. Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model. PLoS One. 2012;7(7):e39817. Epub 2012 Jul 3.
Abstract

Bauer M, Gräbsch C, Schlink U, Klopp N, Illig T, Krämer U, von Berg A, Schaaf B, Borte M, Heinrich J, Herbarth O, Lehmann I, Röder S; for the LISAplus Study Group. Genetic association between obstructive bronchitis and enzymes of oxidative stress. Metabolism. Epub 2012 Jun 25.
Abstract

Hinz D, Bauer M, Röder S, Olek S, Huehn J, Sack U, Borte M, Simon JC, Lehmann I, Herberth G; LINA study group. Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy. 2012 Mar;67(3)
Abstract