Research for the Environment

Department Environmental Immunology

Department Environmental Immunology and Core-Facility Studies

Head of the department:
Dr. Irina Lehmann

Office:

Foreign Language Assistant (german/english/french)
Alice Teipelke

Tel.: + 49 341 235-1265
Fax: +49 341 235-1787

Permoserstraße 15
04318 Leipzig

Building 6.0

office hours

monday, wednesday, thursday: 10am-3pm

tuesday: 9am-3pm and friday: 10am-2pm

The Department Environmental Immunology investigates the influence of environmental factors on the human immune system. Epidemiological studies are performed to study how immune responses are modulated by environmental pollutants and life style factors. In addition, in vitro models are used to ascertain the causal links between exposure and immunomodulation, and to characterise the basic molecular mechanisms.

Data gained in vivo from epidemiological studies and in vitro from experimental models are used to elucidate allergies and other diseases caused by environmental factors. Interest is focused on pollutants stemming from indoor sources.

Recent publications

Bauer M, Linsel G, Fink B, Offenberg K, Hahn AM, Sack U, Knaack H, Eszlinger M, Herberth G A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood Clin Epigenetics. 2015 Aug 6;7(1):81 Abstract

Ali R, Trump S, Lehmann I, Hanke T Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene J Biophotonics. 2015 May;8(5):361-71 Abstract

Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon JC, Lehmann I, Echtermeyer F, Pap T, Averbeck M. Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation Nat Commun. 2015 Jul 13;6:7554 Abstract

Herberth G, Offenberg K, Rolle-Kampczyk U, Bauer M, Otto W, Röder S, Grützmann K, Sack E, Simon J-C, Borte M, von Bergen M, Lehmann I Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases J. Allergy Clin. Immunol. 2015 Jan Abstract

Franck U, Weller A, Röder SW, Herberth G, Junge KM, Kohajda T, von Bergen M, Rolle-Kampczyk U, Diez U, Borte M, Lehmann I; LiNA Study Group Prenatal VOC exposure and redecoration are related to wheezing in early infancy Environ Int. 2014 Dec;73:393-401 Abstract

Gasch M, Goroll T, Bauer M, Hinz D, Schütze N, Polte T, Kesper D, Simon JC, Hackermüller J, Lehmann I, Herberth G Generation of IL-8 and IL-9 producing CD4⁺ T cells is affected by Th17 polarizing conditions and AHR ligands Mediators Inflamm. 2014;2014:182549 Abstract

Herberth G, Bauer M, Gasch M, Hinz D, Röder S, Olek S, Kohajda T, Rolle-Kampczyk U, von Bergen M, Sack U, Borte M, Lehmann I Lifestyle and Environmental Factors and Their Influence on Newborns Allergy Risk study group Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers J Allergy Clin Immunol. 2014 Feb;133(2):543-50 Abstract