Inquiries: Prof. Dr. Beate Escher

We offer the following opportunities at the department of Cell Toxicology for Master and Bachelor Theses in 2018/19:

Measuring freely dissolved concentrations in biological samples

Co-Supervisor: Luise Henneberger and Dr. Nils Klüver

  • Important for in vitro to in vivo extrapolation (replacement of animal testing)
  • Partitioning experiments with different biological samples (serum albumin, liposomes, cell suspensions, FBS, human and fish plasma)
  • Comparison of human and fish plasma in terms of sorption properties

What are we extracting from water with solid phase extraction (SPE)
Supervisor: Beate Escher

  • Bioanalytical assessment of water samples
  • Designed mixtures of chemicals detected in river water samples
  • SPE recovery quantified using bioassays
  • Bioassays targeting hormone pathways and adaptive stress responses (possibly also fish embryo toxicity)

Assessing effects of chemicals and samples on neurite outgrowth
Co-Supervisor: Dr. Rita Schlichting

  • Implementation and validation of in vitro neurotoxicity bioassays on liquid handling platform
  • Establish robust read outs based on image analysis
  • Comparison of assay sensitivity for different test systems

Bioanalytical assessment flame retardants and their trabsformation products
Supervisor: Dr. Beate Escher
Co-Supervisors: Dr. Rita Schlichting and Prof. Kris McNeill

  • Brominated flame retardants can be converted in the light to a number of potentially more toxic transformation products
  • In a collaboration with the Swiss federal Institute of Technology ETH Zürich we synthesised some of these products
  • Your Master thesis encompasses a literature research on the photochemical degradation of flame retardants and the bioanalytical assessment of the single compounds, transformation producst and their mixtures

Determination of Dioxins with Gas Chromatography-High Resolution Mass Spectrometry (GC-HRMS) and linking concentrations to effects in passive sampler extracts of sediment samples
Supervisor: Dr. Beate Escher
Co-Supervisors: Dr. Annika Jahnke and Dr. Melis Muz

  • Method development and validation of dioxins and dioxin like chemicals with a state-of-art GC-HRMS instrument.
  • Analyzing passive sampler and total extracts of sediment samples from the Baltic Sea.
  • Linking observed effects with concentrations of identified chemicals.