PD Dr. Thomas Maskow
CV / Scientific Career
I am highly interested in a quantitative understanding of bioconversions in natural and technical systems. This is a basic prerequisite to develop a sustainable chemistry and to clean up polluted sites. Irreversible thermodynamics is for that purpose though particularly valuable but surprisingly seldom used. Thus, I develop both biothermodynamic models and new real time analytical tools for analysis and control of complex biological systems. The field of applications of such models and tools comprises the adaptation of microbes to hostile environments, food webs in ecosystems, new concepts for bioenergy generation and optimization of technical biosynthesizes. The consideration of heterogeneous systems (e.g. biofilms, subsurface processes) or the inclusion of light (e.g. photosynthesis) and electrical energy (e.g. microbial fuel cells) in biothermodynamic considerations are challenges for the future.
- Energetics of biofilms
- Biothermodynamic models for complex networks in metabolism (system biology) as well as in ecosystems
- Development of thermal bio-chip technologies
- Research on new control strategies for bioprocesses basing on physical signals which reflects metabolic changes in statu nascendi,e.g. calorimetry, impedance spectroscopy and redox processes
- Extremophiles as source and producers of valuable products (main focus: protector molecules like compatible solutes)
Biophysics and biophysical chemistry; study course: Bioprocess engineering (WS), Dresden University of Technology
Innovative potential of white biotechnology; (System biology, Biothermodynamics, Extremophiles); branch of study: Biology and Biochemistry (SS), Leipzig University
Other Professional Activities
- DECHEMA - member of the working group "Bioprocess technology"
- DECHEMA - member of the working group "Biothermodynamics"
- Editorial Board Member of "Engineering in Life Sciences", "Bioenergetics"
Selected Co-operations / Projects
- Title: Glycolysis: Thermodynamics and predictions of metabolic pathways. Funding: DFG (01.06.2016 - 31.05. 2019), Cooperation: S. Verevkin (Uni Rostock), Ch. Held (TU Dortmund)
- Title: Global Climate Changes Influence CO2-Fixation by Phytoplankton Photosynthesis - a Biothermodynamic Analysis. Funding: HIGRADE-Helmholtz (01.09.2008 - 31.08.2011), Cooperation: Ch. Wilhelm (Uni Leipzig)
- Title: Biothermodynamics and Miniaturized Calorimeters for Biofilm Analysis and Control. Funding: DFG (01.03.2010 - 29.02.2012), Cooperation: J. Lerchner (TU Freiberg)
- Title: Development of calorimeters as real time instruments to analyze and control complex environmental bioprocesses. Funding: DAAD/CSC (01/2007 - 12/2009) Cooperation: Yao Jun -Wuhan University China
- Title: Analysis and control of bioprocesses with chip-calorimetry. Funding: AiF (01.03.2007 - 27.02.2009), Cooperation: J. Büchs - RWTH Aachen, J. Lerchner - TU Freiberg + 7 medium sized companies
- Title: Biothermodynamic characterization and analysis of biofilms with new chip-calorimetry Funding: DFG (01.07.2006 - 30.06.2008), Cooperation: J. Lerchner (TU Freiberg)
- Title: Production of chiral R-3-hydroxyalkanoates from methylotrophic bacteria using renewable raw materials, Funding: AiF (03/2007 - 11/2008), Cooperation: U. Breuer - UFZ, L. Braun - UIT Dresden
- Title: From waste products to valuable materials: Innovative use of calorimetry and genetic engineering for increasing the efficiency of a procedure for the synthesis of compatible solutesn, Funding: AiF (02/2004 - 01/2007), Cooperation: U. Breuer - UFZ, W. Loettel - BEC GmbH
- Title: Optimization of genetically modified yeasts as producers of biopolymers using renewable raw materials, Funding: IB Investitionsbank Sachsen-Anhalt (12/2004 -12/2006), Cooperation: U. Breuer - UFZ, G. Kunze - Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben, W. Loettel - BEC