PD Dr. Tobias Polte

Kontakt

PD Dr. Tobias Polte
Wissenschaftler und Leiter der Helmholtz-Hochschul-Forschungsgruppe

Department Umweltimmunologie
Helmholtz-Zentrum für Umweltforschung – UFZ
Permoserstr. 15
04318 Leipzig


Tel.: +49 341 235-1545
Fax: +49 341 235-1787

Tobias Polte

Research Interests

Currently we are investigating in a murine model of allergic asthma the role of environmental pollutants as adjuvant or causal risk factors in allergy development. Thereby we are also looking on the effect of prenatal maternal exposure to environmental pollutants on the allergy risk of the offspring. Another topic are gene-environment interactions. The long-term objective of our research is the development of new prevention and therapeutic strategies for allergic diseases.



Curriculum vitae / Scientific career

1991 - 1995

Study of Pharmacy at the Martin Luther University, Halle

1996 - 1997

Graduand at the Department of Pharmacology and Toxicology, Martin Luther University, Halle

1997 - 2000

PhD, Department of Pharmacology and Toxicology (Prof. Henning Schröder)
Martin Luther University, Halle

2000 - 2002

Postdoc at the Department of Pharmacy and Pharmacology, University of Bath (UK) PI: Prof. Rex Tyrrell

2002

Postdoc at the Department of Pediatrics, Stanford Medical School, Stanford University (USA), PI: Prof. Phyllis Dennery

2002 - 2007

Postdoc in the Junior Research Group of Prof. Gesine Hansen at the Medical School of the Martin Luther University, Halle

since 2007

Head of a Helmholtz University Young Investigators Group at the UFZ and the University of Leipzig

2012

Habilitation and Venia legendi at the Leipzig University, Faculty of Medicine

Awards

2000

Dorothea Erxleben Award of the Martin Luther University, Halle

2000 - 2002

Postdoctoral fellowship of the German Research Council (DFG)

2007

Wilhelm-Roux Award of the Martin Luther University, Halle

2010

Brigitte-Gedek-Science-Award of the Society for Mycotoxin Research


Publications

Bauer T, Trump S, Ishaque N, Thürmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm J, Röder S, Herberth G, Takada E, Mücke O, Winter M, Junge KM, Grützmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Geörg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R, Lehmann I (2016). Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol 12:861

Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon JC, Lehmann I, Echtermeyer F, Pap T, Averbeck M (2015). Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation. Nat Commun 6: 7554

Meister J, Le Duc D, Ricken A, Burkhardt R, Thiery J, Pfannkuche H, Polte T, Grosse J, Schoneberg T, Schulz A (2014). The G Protein-coupled Receptor P2Y14 Influences Insulin Release and Smooth Muscle Function in Mice. J Biol Chem 289:23353-66

Petzold S, Averbeck M, Simon JC, Lehmann I, Polte T (2014). Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model. Plos One 9: e100468

Gasch M, Goroll T, Bauer M, Hinz D, Schütze N, Polte T, Kesper D, Simon JC, Hackermüller J, Lehmann I, Herberth G (2014). Generation of IL-8 and IL-9 producing CD4⁺ T cells is affected by Th17 polarizing conditions and AHR ligands. Mediators Inflamm:182549

Rothemund S, Sonnichsen F, Polte T (2013). Therapeutic potential of the peptide leucine arginine (pLR) as a new non-plant bowman-birk like serine-protease inhibitor. J Med Chem 56: 6732-6744

Reiprich M, Rudzok S, Schütze N, Simon JC, Lehmann I, Trump S, Polte T (2013). Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. Allergy 68: 481-489

Bönisch U, Böhme A, Kohajda T, Mögel I, Schütze N, von Bergen M, Simon JC, Lehmann I, Polte T (2012). Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model. Plos One 7: e39817

Schubert K, Polte T, Bönisch U, Schader S, Holtappels R, Hildebrandt G, Lehmann J, Simon JC, Anderegg U, Saalbach A (2011). Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation. Eur J Immunol 41: 645-56.

Bohnekamp J, Böselt I, Saalbach A, Tönjes A, Kovacs P, Biebermann H, Manvelyan HM, Polte T, Gasperikova D, Lkhagvasuren S, Baier L, Stumvoll M, Römpler H, Schöneberg T (2010). Involvement of the chemokine-like receptor GPR33 in innate immunity. Biochem Biophys Res Commun 396: 272-277

Schütze N, Lehmann I, Bönisch U, Simon JC, Polte T (2010). Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med 181: 1188-1199.

Polte T, Fuchs L, Behrendt AK, Hansen G (2009). Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model. Eur J Immunol 39: 1736-1742

Bickert T, Trujillo-Vargas CM, Duchs M, Wohlleben G, Polte T, Hansen G, Oelschlaeger T, Erb KJ (2009). Probiotic Escherichia coli  Nissle 1917 suppresses allergen-induced Th2 responses in the airways. Int Arch Allergy Immunol 149: 219-230

Polte T, Hennig C, Hansen G (2008). Allergy prevention starts before conception: Materno-fetal transfer of tolerance protects from the development of asthma. J Allergy Clin Immunol 122: 1022-1030

Müller U, Stenzel W, Köhler G, Polte T, Blessing M, Mann A, Piehler D, Brombacher F, Alber G (2008). A gene-dosage effect for IL-4Ralpha expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis 198: 1714-1721

Polte T, Hansen G (2008). Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently prevents the offspring from allergic asthma. Clin Exp Allergy 38: 1950-1958

Müller U, Stenzel W, Köhler G, Werner C, Polte T, Hansen G, Schütze N, Straubinger RK, Blessing M, McKenzie ANJ, Brombacher F, Alber G (2007). IL‑13 induces disease‑promoting type-2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol 179: 5367-77

Polte T, Jagemann A, Foell J, Mittler RS, Hansen G (2007). CD137 ligand prevents the development of Th2-cell mediated allergic asthma by IFN-gamma producing CD8+ T cells. Clin Exp Allergy 37: 1374-1385.

Lin Q, Weis S, Yang G, Weng YH, Helston R, Rish K, Smith A, Bordner J, Polte T, Gaunitz F, Dennery PA (2007). Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem 282: 20621-20633.

Trujillo-Vargas CM, Wohlleben G, Polte T, Hansen G, Ehlers S, Erb KJ (2007). Helminth derived products inhibit the development of allergic responses in mice. Am J Respir Crit Care Med 175:336-44.

Basu-Modak S, Ali D, Gordon M, Polte T, Yiakouvaki A, Pourzand C, Rice-Evans C, Tyrrell RM (2006). Suppression of UVA-mediated release of labile iron by epicatechin – a link to lysosomal protection. Free Radic Biol Med 41: 1197-2004

Polte T, Behrendt AK, Hansen G (2006). Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol 118: 942-948

Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G (2006). CD137-mediated immunotherapy for allergic asthma. J Clin Invest 116: 1025-1036

Trujillo-Vargas CM, Mayer KD, Bickert T, Palmetshofer A, Grunewald S, Ramirez-Pineda, JR, Polte T, Hansen G, Wohlleben G, Erb KJ (2005). Vaccination with Th1 directing adjuvants have different suppressive effects on the development of allergen-induced Th2 responses. Clin Exp Allergy 35: 1003-1013

Polte T, Tyrrell RM (2004). Involvement of lipid peroxidation and organic peroxides in UVA-induced MMP-1 expression. Free Radic Biol Med 36: 1566-1574

Polte T, Hemmerle A, Grosser N, Abate A, Schröder H (2002). Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Free Radic Biol Med 32: 56-63

Polte T, Abate A, Dennery PA, Schröder H (2000). Heme oxygenase-1 is a cyclic GMP-inducible protein and mediates the cytoprotective action of nitric oxide. Arterioscler Thromb Vasc Biol 20: 1209-1215

Polte T, Schröder H (1998). Cyclic AMP mediates endothelial protection by nitric oxide. Biochem Biophys Res Commun 251: 460-465

Oberle S, Polte T, Abate A, Podhaisky HP, Schröder H (1998). Aspirin increases ferritin synthesis in endothelial cells: A novel antioxidant pathway. Circ Res 82: 1016-1020

Podhaisky HP, Abate A, Polte T, Oberle S, Schröder H (1997). Aspirin protects endothelial cells from oxidative stress - possible synergism with vitamin E. FEBS Lett 417: 349-351

Polte T, Oberle S, Schröder H (1997). The nitric oxide donor SIN-1 protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: Possible role for cyclic GMP and heme oxygenase. J Mol Cell Cardiol 29: 3305-3310

Polte T, Oberle S, Schröder H (1997). Nitric oxide protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: possible involvement of cyclic GMP. FEBS Lett 409: 46-48